DRSC/TRiP Functional Genomics Resources

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Protein Alignment tai and ncoa2

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:NP_571852.1 Gene:ncoa2 / 81884 ZFINID:ZDB-GENE-010406-3 Length:1505 Species:Danio rerio


Alignment Length:1957 Identity:418/1957 - (21%)
Similarity:627/1957 - (32%) Gaps:723/1957 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 SPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRG-DM 270
            |.:..||::.|.|..:.|::..|.:..|..   |.:.|||.||.|:.|||:|:|::..|... |.
Zfish     2 SAVGENSSDPARSEAQKRKEGPSDLLGPSP---KRSTEKRNREHESKYIEELAELIFANFNDIDN 63

  Fly   271 TSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTR 335
            .:.||||.|||.:.|:..|:|  |.|.:   :.:.|.:.                          
Zfish    64 FNVKPDKCAILKETVKQIRQI--KEQEK---AAAANEDE-------------------------- 97

  Fly   336 CSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGI 400
                         ||:.:||||...:.:.. .||.:     ..|||:.:       ...||..|.
Zfish    98 -------------VQKADVSSTGQSVIDKD-ALGPM-----MLEALDGF-------FFVVNMEGN 136

  Fly   401 IESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSA 465
            |...::|:...:.|.::||.:..:|..|:.||||  |.|.|.:..:...|...|:.|.       
Zfish   137 IVFVSENVTQYLRYNQEELMNTSVYSILHVGDHA--EFIKNLLPKSHVNGVPWSSENP------- 192

  Fly   466 GTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSNC 530
                                                   ::.|.:...||||.....|.:|..: 
Zfish   193 ---------------------------------------RRNSHTFNCRMLVNPHSEAEETQDH- 217

  Fly   531 EEKPLRQSGHQDKYEEVVLIAA----PVKDDA-DASSSVLCLITR-PEDESPLEINIQQHVQQQP 589
                    ..|.|||.:...|.    .:|::. |..|.::|:..| |..|.|:       :..| 
Zfish   218 --------EAQQKYETMQCFAVSEPKSIKEEGEDFQSCLICVARRVPMKERPM-------LPTQ- 266

  Fly   590 IEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQ--DLCHPHDLSTLKSHLRDIQDSASA 652
             |..|.:.|:.|||.:||.:.||...|...:..|.|..|  .|.:..|:|..|.|.:::.....|
Zfish   267 -ESFTTRQDLQGKITSLDTSLLRASMKPGWEDLVRRCIQRFHLQNDGDISFAKRHQQEVIRHGQA 330

  Fly   653 NSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNT 717
            .||        :.| |.|..|. .|..|.|  |:|..:.:..|....||:..|...:        
Zfish   331 FSP--------IYR-FSLSDGT-IVSAHTK--SKLVRSSSTNEPQLYMSLHILQREQ-------- 375

  Fly   718 GAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQ 782
                      .:|.||  ..|.::......|:.:.....:|||.:|                   
Zfish   376 ----------PVCGMA--SDLGNAQTMGKPMNPMSSPNTAGSSCTP------------------- 409

  Fly   783 QGGGGN-STQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEH 846
            ||.... |:.|::...|          |.|::.....|.|...:.|.||.........|..|.:.
Zfish   410 QGQDATISSNTSTFPSP----------GAQKEPGAMHRFGCPGTMSHSATMQAATPQGSGYPLKL 464

  Fly   847 SFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCASPA 911
            |                    .||.|               :..:.:||    |..||.|..||.
Zfish   465 S--------------------SPSQG---------------SPGMLSPR----HRASPGVAGSPR 490

  Fly   912 TPYQLSSHSAASLPSPQSN-ASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNSSSSNP 975
            .|....| .|.||.||.|. .|:.|||.|....|.:.||.:...:.:.:........:..|....
Zfish   491 LPPPQFS-PAGSLHSPASMCTSSTGGNGGAGANHGYTSSSLNALQALSECHGVSHGQSLGSPDRK 554

  Fly   976 LLGGGLPNGVGGMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLLTKSQSMAGGLGGLGDDEKYF 1040
            |   |.| ....:.:|.....:.:.|:...:|.|.|.                  |..|.||...
Zfish   555 L---GSP-AAHSVAVSHHLINKMSVPESFGEQNQSEQ------------------GTPGQDEGID 597

  Fly  1041 KPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSEDD 1105
            .|   .:||            |.:|.||.:.      |:........|..:..||:||..|:|..
Zfish   598 LP---RDEK------------GNLGQFGNLD------GSDPQSRLRDNKSHTKLLQLLTTKTEPI 641

  Fly  1106 DGNG----SGGGPGSMNNSRQSELMRQLKNPDGGSHGMHRNSASGNMST------EDLKAMLKIQ 1160
            :...    :||.||             .|:...|:.||.....:|:.:|      :.|..:|:..
Zfish   642 ESTSPPPMAGGEPG-------------CKDGGAGNGGMGSQGGNGSHATSLKEKHKILHRLLQNS 693

  Fly  1161 SDP----SLNRKRSLNEPDDDPSA----------KRSEDKPSKLCTQNKMLAKLLQNPPKIPKAP 1211
            |.|    .|..:.:..|...|.:.          |:....|.|  ..|.:|..||.....:.|..
Zfish   694 SSPVDLAKLTAEATGKELCQDSAGGTAGVPELAIKQEPVSPKK--KDNALLRYLLDKDDNVLKGK 756

  Fly  1212 NPE-QPLQVK-------------------------TLPDITSSTVSS-----TLAAPGNLISA-- 1243
            ..: :|.::|                         .|.||.....:|     |.:.|.:|.||  
Zfish   757 GIKMEPGEIKEEGGKMTGIKTEKTDGGYDRVEPSSELDDILDDLQNSQPGLFTDSRPVSLPSAVD 821

  Fly  1244 ---------GSTGPKAAANRNRKQQQQQQQQQQQQQQQQVAGIPSQ------------------- 1280
                     ..||...|   |...|||:..|....||...|..|.|                   
Zfish   822 KQSIINDILQMTGESGA---NMSPQQQRALQTAVSQQNFPAPRPGQPGRAPPVRSVSLDMNMPPK 883

  Fly  1281 -QQQQQP----NDVYLSQQQQQQL--------------------QSPQLAFQHQQLATTATTSIT 1320
             .|.|.|    |:.|...|||..:                    ..|::..|........|  :.
Zfish   884 GAQGQYPMMRNNNPYSIMQQQGMMGNHAVMPNQPNMVNAGVMGNNGPRVGMQQDGWGAQGT--VG 946

  Fly  1321 TAASTSAAAAAAAAILGEG---------------------------------------------- 1339
            :|||.:.||.|....|.:|                                              
Zfish   947 SAASPATAAPAGQHSLPQGALHSRMVPNPATGMPMRPNSQPGPRPMLQPQMMANAQSNMDMGMAG 1011

  Fly  1340 ---------DSELSKLLDSVMEYYP---------------DDT--PIVTNAPSEASA-------- 1370
                     .::.:...||||...|               :|.  |..:..|::..|        
Zfish  1012 HQFPQQQAPPNQTAPWPDSVMPIEPVPFGNQSSSMYGGSQEDVLCPPASEGPADEGALLSQLYSA 1076

  Fly  1371 ------INDIQKSLML--------DVESAAF-GNDLNQQLMMTQQ-QQHQQQQQQQQLLALQLAQ 1419
                  :.:|.::|.:        .||...| |.|  ..:||.|: ..:.|||.......:|.|.
Zfish  1077 LKDFDGLEEIDRALGIPALVGQAQPVEQDQFPGQD--PSMMMDQKPPMYGQQQYASSPANMQQAG 1139

  Fly  1420 QQQQQ------RQQHLQQPPAYPGMLNMQ--------------------QQQHQQQQQQNQQHIM 1458
            ....|      .|..:.|.|.|| ||.||                    |.||:.|.|||:|.:|
Zfish  1140 YTPMQDATFHGLQGQMGQRPGYP-MLRMQARPGLRPGGVVPNQPNTLRLQLQHRLQAQQNRQPMM 1203

  Fly  1459 QRLEAMRNQGNQGFQRPPPMYP-ARGRGPMNAVATPGGVVLPAQQQ---LRNIRQQQQLAAAQQK 1519
            .::..:.|..       .|:.| ...:|.:||       .:.||:|   |.|..:|:||  .||:
Zfish  1204 NQMGGVSNMN-------LPLRPNVPNQGTINA-------QMLAQRQRELLSNHLRQRQL--DQQR 1252

  Fly  1520 ERLLQQQQK-------QQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGA 1577
            ::..||||:       |.|.:|.|                 ::...|||...::|       ...
Zfish  1253 QQQQQQQQQRSLAMRAQGLTMPPN-----------------MAAAAAGMPGAMSN-------PRI 1293

  Fly  1578 PNVSLSRTNLPSDAQLSPNFAQTLMQQQLSPGRSAPYSPQPNQGYAPQFPQPGQRLSPQQQQQLS 1642
            |..:|.:...|      ||:...|..   .|..::|:||.     :|..|.|          ||.
Zfish  1294 PQANLQQFPYP------PNYGTGLAS---PPPSTSPFSPG-----SPNLPAP----------QLL 1334

  Fly  1643 QQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGG------GGGGG--- 1698
            .....:..|..||.|    |..|..:..||:   :.||.||:|..|:.|.|      ||.||   
Zfish  1335 SHSAMHGSQMSLANQ----GMLGSLSGQFGA---VMSPQMQHSAFQFPSSGMSQQSDGGFGGAAT 1392

  Fly  1699 PGGPLPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGLNSPGAVGPGGNPAAQAALQRQ 1763
            |..||.|...|..   .:||:               ||.|             ||          
Zfish  1393 PQSPLMSPRMGHA---QSPMM---------------QQAQ-------------GN---------- 1416

  Fly  1764 NSFQGQGGGGATTPDGSGVGFGGPQSPYGTNVNVFQQQQLQRLQRQGSVPQATQHLPGSPRFGSS 1828
            :|||       ::||.:    |.||....|| ::|.||         |.||.:|....:...|: 
Zfish  1417 SSFQ-------SSPDMN----GWPQGNINTN-SMFTQQ---------SPPQFSQQANNNMYNGN- 1459

  Fly  1829 PGSSNNTDSSAAAGNQQQQQQQQQQQQQQHQQQQHQQLMNGLSMSPHPHPHPAMMGVGGMGSGGG 1893
             |.:.|...:|.:.|..|...|                                |.:..|.||.|
Zfish  1460 -GMNLNVSMAANSSNMGQMGNQ--------------------------------MSMSSMNSGPG 1491

  Fly  1894 NGIIGLG 1900
            :|:..:|
Zfish  1492 SGMANMG 1498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 21/51 (41%)
PAS 377..442 CDD:214512 19/64 (30%)
PAS_11 591..711 CDD:291273 35/121 (29%)
ncoa2NP_571852.1 basic helix-loop-helix DNA-binding domain 18..86 27/72 (38%)
HLH 36..89 CDD:197674 25/54 (46%)
PAS 119..176 CDD:214512 19/70 (27%)
PAS A domain 125..184 17/67 (25%)
PAS_11 267..375 CDD:291273 35/119 (29%)
PAS B domain 269..330 18/60 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..515 40/191 (21%)
NCOA_u2 460..567 CDD:293270 33/150 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..562 4/23 (17%)
SRC-1 629..705 CDD:285981 21/88 (24%)
NR Box 630..634 2/3 (67%)
NR Box 686..690 1/3 (33%)
DUF4927 728..803 CDD:292896 13/76 (17%)
NR Box 742..746 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 835..871 11/38 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..962 7/24 (29%)
Nuc_rec_co-act 1061..1106 CDD:285967 6/44 (14%)
LLXXLXXXL motif. /evidence=ECO:0000255 1069..1077 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1246..1265 8/20 (40%)
HAT-like domain 1310..1378 25/92 (27%)
DUF1518 1354..1410 CDD:284808 20/61 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1475..1505 9/56 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581483
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 154 1.000 Inparanoid score I4291
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10684
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.980

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