DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tai and arntl1a

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	NP_571652.1	Gene:	arntl1a / 58098	ZFINID:	ZDB-GENE-000509-1	Length:	626	Species:	Danio rerio

Alignment Length:	719	Identity:	136/719 - (18%)
Similarity:	235/719 - (32%)	Gaps:	267/719 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 AAIMNAVASPISAN--SANSATSGRKIRRK--------------------TDSKVNL----PQSQ 237
            ::.||...|..||:  |::..|:|....||                    ||....|    .|.:
Zfish     9 SSTMNEFMSQSSADLISSSIGTTGMDYNRKRKGSTTEYQIDGFSFDDSMDTDKDKTLGRDEQQGR 73

  Fly   238 INKCNN-----EKRRREAENGYIEQLSEIL-TLNKRGDMTSTKPDKAAILNQVVRTYREICDKGQ 296
            |.....     |||||:..|.:|::|:.:: |.|    ..|.|.||..:|...|:..:.:  :|
Zfish    74 IKNAREAHSQIEKRRRDKMNSFIDELASLVPTCN----AMSRKLDKLTVLRMAVQHMKTL--RG- 131

  Fly   297 NRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPL 361
                            .||..|.:|     .||...|.
Zfish   132 ----------------ATNPYTEAN-----YKPAFLSD--------------------------- 148

  Fly   362 PEPSLLLGQVPEISAYFEALEHYI--SGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPL 424
                             :.|:|.|  :..|::.:.....|.|...::::..::.|.:.:|..|.|
Zfish   149 -----------------DELKHLILRAADGFLFVVGCDRGKILFVSESVYKILNYTQNDLIGQSL 196

  Fly   425 YMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGS--SAGTSAGVWGDLEELNNGNASQGS 487
            :.||:..|.||::..:             |::::.|...  .|.|...|..|:..
Zfish   197 FDYLHPKDIAKVKEQL-------------SSSDTAPRERLIDAKTGLPVKTDITP---------- 238

  Fly   488 NSSGAGGLGGAGGAAAGKKRSISTK-------VRMLVKDTRTATQTSSNCEEK--------PLRQ 537
                     |.....:|.:||...:       |:|..||      ..|.|.:|        .:..
Zfish   239 ---------GPSRLCSGARRSFFCRMKCNRPSVKMEDKD------FPSTCSKKKADRKSFCTIHS 288

  Fly   538 SGHQDKYEEVVLIAAPVK---------DDADASSSVLCLITRPEDESPLEINIQQHVQQQPIE-- 591
            :|:...:       .|.|         |:...:.|.|..|.|          :..|:..||:.
Zfish   289 TGYLKSW-------PPTKMGLDEDNEPDNEGCNLSCLVAIGR----------LHPHIVPQPMNGD 336

  Fly   592 ------QMTFKLDIHGKILTLD--PTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDI-- 646
                  :...:..|.||.:.:|  .||:.....|.|   :|..:.:..|..|:..|....|.:
Zfish   337 IRVKPTEYVSRHAIDGKFVFVDQRATAILAYLPQEL---LGTSFYEYFHQDDIGHLAECHRQVLQ 398

  Fly   647 -QDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSEN 710
             ::..|.|           ...|:::.|:   ::.:::....|:|....|.::|:|..|::
Zfish   399 MREKISTN-----------CYKFKIKDGS---FITLRSRWFSFMNPWTKEVEYIVSTNTVV---- 445

  Fly   711 DMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDG-LHGGTGSGSSSSPAASGMLPTHLL 774
                      ||.:..|      ..||.:.:..|..|||. |..|.|.|..         |..::
Zfish   446 ----------SGSMLEG------ADPSYSQTASSPQSMDSVLTSGDGGGKR---------PLQIV 485

  Fly   775 GGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTA 839
            .|:.||.:.|.|       .:|..:....:        :.|:.:.|..||..||..|     .||
Zfish   486 PGIPGGTRAGAG-------KIGRMIAEEVM--------EIQRIRGSSPSSCGSSPLN-----ITA 530

  Fly   840 SPAP 843
            :|.|
Zfish   531 TPPP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	17/56 (30%)
		PAS	377..442	CDD:214512	15/66 (23%)
		PAS_11	591..711	CDD:291273	23/132 (17%)
arntl1a	NP_571652.1	HLH	78..130	CDD:278439	16/57 (28%)
		PAS	150..257	CDD:279347	25/138 (18%)
		PAS	153..212	CDD:214512	14/58 (24%)
		PAS_11	343..446	CDD:291273	23/133 (17%)
		PAS	345..440	CDD:238075	21/111 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900