Protein Alignment tai and BMAL2

DIOPT Version :10

• Sequence 1: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Sequence 2: NP_001381453.1
• Gene: BMAL2 / 56938
• HGNCID: 18984
• Length: 647
• Species: Homo sapiens
• Alignment Length: 734
• Identity: 134/734 - (18%)
• Similarity: 246/734 - (33%)
• Gaps: 233/734 - (31%)

  Fly   203 NAVASPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKR 267
            |.:...:|.....||:||.:: ...:.:|.:...:......|||||:..|..||:||.::   .:
Human    87 NPLTYLLSTRIEISASSGSRV-EDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMI---PQ 147

  Fly   268 GDMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQAT 332
            .:..:.|.||..:|...|:..|.:  ||                 .||:...||.
Human   148 CNPMARKLDKLTVLRMAVQHLRSL--KG-----------------LTNSYVGSNY---------- 183

  Fly   333 STRCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYI--SGVGWVLLQV 395
                                          .||.|..         ..|.|.|  :..|::.:..
Human   184 ------------------------------RPSFLQD---------NELRHLILKTAEGFLFVVG 209

  Fly   396 NANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGP 460
            ...|.|...::::..::.|::..|..|.|:.:|:..|.||::..:::...:|.....:
Human   210 CERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLID------- 267

  Fly   461 GGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKV---RMLVKDTRT 522
                |.|...|..:|.                   .|.....:|.:||...::   ::.||:...
Human   268 ----AKTGLQVHSNLH-------------------AGRTRVYSGSRRSFFCRIKSCKISVKEEHG 309

  Fly   523 ATQTSSNCEEK---PLRQSGHQDKYEEVVLIAAPVKDDADASSSVLCLIT--------RPEDESP 576
            ....|...|.:   .:..:|:...:...::.....::....:|:..||:.        .|::..
Human   310 CLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSG- 373

  Fly   577 LEINIQQHVQQQPIEQMTFKLDIHGKILTLD--PTALREPFKQHLQTWVGRLWQDLCHPHDLSTL 639
             |||:      :|.|.:| :..::||.:.:|  .||:.....|.|   :|....:..|..|.:.|
Human   374 -EINV------KPTEFIT-RFAVNGKFVYVDQRATAILGYLPQEL---LGTSCYEYFHQDDHNNL 427

  Fly   640 -KSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQ 703
             ..|...:|......:.         |..||.:.|:   :|.:|:....|.|....|.::|:||.
Human   428 TDKHKAVLQSKEKILTD---------SYKFRAKDGS---FVTLKSQWFSFTNPWTKELEYIVSVN 480

  Fly   704 TLLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGT--GSGSSSSPAAS 766
            ||:     :..|..|..|       ....:...|..||..|.:|:.|:..||  |:||..:..|:
Human   481 TLV-----LGHSEPGEAS-------FLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIAN 533

  Fly   767 GMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIING---TGLQQQQQQQQRSGASSSASS 828
            .:|...                         .|.||:.::.   |||.:           .:.:.
Human   534 EILDLQ-------------------------RLQSSSYLDDSSPTGLMK-----------DTHTV 562

  Fly   829 SANALVNAFTASPAPAE------------------HSFYGSDTFEFDIAAHSSSFE--------- 866
            :..::.|.....|:|:|                  |....||..:.|..|...:.:
Human   563 NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNY 627

  Fly   867 LDPSGGVG--------AWT 877
            |:..||:|        .||
Human   628 LEAEGGLGDPGDFSDIQWT 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	bHLH_SF	239..291	CDD:469605	16/51 (31%)
		PAS	377..442	CDD:214512	14/66 (21%)
		PAS_11	590..711	CDD:464214	29/123 (24%)
BMAL2	NP_001381453.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..73
		Interaction with PER2. /evidence=ECO:0000250|UniProtKB:Q2VPD4	57..269		47/264 (18%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9WTL8	60..65
		bHLH-PAS_ARNTL2_PASD9	119..178	CDD:381475	20/80 (25%)
		Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:Q9WTL8	188..198		3/18 (17%)
		PAS	203..298	CDD:238075	20/124 (16%)
		PAS_11	381..483	CDD:464214	28/117 (24%)
		Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:Q9WTL8	403..411		2/10 (20%)