Protein Alignment tai and ncoa3

DIOPT Version :9

• Sequence 1: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Sequence 2: XP_021335474.1
• Gene: ncoa3 / 564519
• ZFINID: ZDB-GENE-051107-8
• Length: 1504
• Species: Danio rerio
• Alignment Length: 1929
• Identity: 379/1929 - (19%)
• Similarity: 595/1929 - (30%)
• Gaps: 682/1929 - (35%)

  Fly   207 SPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNN-----EKRRREAENGYIEQLSEILTLNK 266
            |.:..||.....|.||  ||           ::.|:.     :|||||.|:.|||:|:|:::.|.
Zfish     2 SGVGENSLEPLCSDRK--RK-----------LSTCDTPGQGCDKRRREQESKYIEELAELISANL 53

  Fly   267 RG-DMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQ 330
            .. |..:.||||.|||.:.||..|:|.::|:
Zfish    54 SDIDSFNVKPDKCAILKETVRQIRQIKEQGK---------------------------------- 84

  Fly   331 ATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPE-----PSLLLGQVPEISAYFEALEHYISGVGW 390
                  |.|..|:     ||:.:||||...:.:     |.||           :||:.:
Zfish    85 ------SSCGDDD-----VQKADVSSTGQGVIDKDHLGPLLL-----------QALDGF------ 121

  Fly   391 VLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSA 455
             |..|:..|.|...:.|:...:.|:::||.:..:|..|:..|..:|              :.|..
Zfish   122 -LFVVSREGSIVFVSDNVTQYLQYKQEELINTSIYNILHEEDREEL--------------HKNLP 171

  Fly   456 NNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSS---------GAGGLGGAGGAAAGKKRSIST 511
            .::||...|       ||       |::|:..:.:         |.||.||..||..
Zfish   172 KSNGPNSVS-------WG-------GDSSRQKSHTFNCRMLVKFGHGGPGGEEGAGG-------- 214

  Fly   512 KVRMLVKDTRTATQTSSNCEEKPLRQSGHQDKYEEVVLIA-----APVKDDADASSSVLCLITRP 571
                                          .:||.:...|     |.:::..|..|.::|:..|.
Zfish   215 ------------------------------PRYETMQCFALTQPKAMMEEGEDLQSCMICVARRV 249

  Fly   572 EDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDL---CHP 633
                         ...:..|:.:.:.::.||::.::..:|       |.|.:...|:||   |..
Zfish   250 -------------TAVERTERFSTRHELSGKLIEIEQQSL-------LHTTMRPGWEDLVRRCMQ 294

  Fly   634 HDLS-------TLKSHLRDIQDSASANSPGAGAGTSVVSRPFRLRL--GAPDVYVHVKANSRLFL 689
            ..|.       :.|.|..:......|.:|           |:|..|  |.|   |..:..|.|..
Zfish   295 MFLHRSEGQPWSYKRHYHEAYVHGRAETP-----------PYRFSLSDGTP---VTAQTRSELCR 345

  Fly   690 NQTPGEGDFIMSVQTLLNSEND------------MNSSNTGAGSG-----GLGLGQLCAMAPSPS 737
            |....:....:|...|...:|.            |.::|..|..|     |.|:.:...|.|
Zfish   346 NPVTSDPHTFLSTHLLQREQNGYRPNQGGVMRSVMGNANPNAQMGMGNTRGYGMNEQGHMGP--- 407

  Fly   738 LASSLLSSLSMDGLHGGT--GSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLM 800
                          .||.  |.|:..:.    |.|.|.:..:            .|..|:....|
Zfish   408 --------------RGGAMYGPGNRMNQ----MNPMHQMNQM------------NQMNSMNQMNM 442

  Fly   801 SSA-IINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEH---SFYGSDTFEFDIAAH 861
            :.. .:|..|...|..|..:       .:|.|.:     ..|...:|   .|:|
Zfish   443 NQMNCMNQMGSMNQMNQMNQ-------MNSMNQM-----GHPGMNQHQQGQFHG----------- 484

  Fly   862 SSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCASP---ATPYQLSSHSAAS 923
                    .||.|....|     .|..:|...|...:..| ||.:..||   |:|:     |...
Zfish   485 --------GGGYGMVMTS-----PSQGSPGMNPGQQNLMG-SPRIRGSPKMGASPF-----SPGG 530

  Fly   924 LPSPQSNASAGG--GNYGGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNSSSSNPLLGGGLPNGVG 986
            :.||......||  |:.|....::|.||.:...:.:.:.                :|..||:.
Zfish   531 MHSPMGPVGMGGSSGSSGPSVGNTFSSSSLNALQAISEG----------------VGSSLPSA-- 577

  Fly   987 GMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLL--TKSQSMAGGLG----GLGDDEKYFKPEGS 1045
              |.|...:...:|.....|..||......:.:.  :||.|.|...|    .....|...||:..
Zfish   578 --LNSPAHKSDSSPNINSTQSSQQGPIGNNKPITSDSKSPSSAHSTGLDQQQASSTENTDKPDSQ 640

  Fly  1046 EEEKHASGGFKMGGQPGGMG-------MFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSE 1103
            ..:..::||......|.|.|       :..|...:|.|...|..:  .|.:..||        ..
Zfish   641 SNKDGSAGGEVNRRVPDGKGHKKLLQLLTSPTEEIGIGTATSGPV--PGRASTPM--------GS 695

  Fly  1104 DDDGNGSG-GGPGSMNNSRQSELMRQLKNPDGGSHGMHRN-SASGNMSTEDLKAMLKIQSDPSLN 1166
            |....||| ..|.|...|..|          |.|.|.:.| .:||.:|:...
Zfish   696 DPKETGSGMMSPSSTGVSSSS----------GSSSGNNVNQQSSGGVSSTAC------------- 737

  Fly  1167 RKRSLNEPDDDPSAKRSEDKPSKLCTQNKMLAKLLQNPPKIPKAPNPEQPLQVKTLPDITSSTVS 1231
                       ||...|   ...|..::|:|.|||||.               .|..|:...|..
Zfish   738 -----------PSGHHS---THTLQEKHKILHKLLQNG---------------NTPDDVARITAE 773

  Fly  1232 STLAAPGNLISAGSTGPKAAANRNRKQQQQQQQQQQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQ 1296
            :|     ...|..|..|.|.......:|:|...::.::.|..:..:.::...::|.
Zfish   774 AT-----GKSSLSSEHPGAEGRNLELKQEQHSPKEGKKPQALLHYLLNKDDSKEPG--------- 824

  Fly  1297 QQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSVMEYYPDDTPIV 1361
                           ||.....:....:..|:....|.:.....|.             .::.:.
Zfish   825 ---------------ATEVKPKLEELEARGASGGQGAGVTTSSSSN-------------QESKVK 861

  Fly  1362 TNAPSEASAINDIQKSLM-----LDVESAAFGNDL-NQQLMMTQQQQHQQQQQQQQLLALQLAQQ 1420
            ...|.|..::..|...|.     :.|:|.:.|::: |:|........|.::.     :.:...|:
Zfish   862 LEQPDELESLESILGGLRNPGPGMFVDSGSGGSEVGNKQGNGPNSTAHDREG-----VGMGSGQR 921

  Fly  1421 QQQQRQQHLQ-QPPAYPGML-------NMQQQQHQQQQ----QQNQQHIMQRLEAMRNQGNQGFQ 1473
            ...||...:. :|.:.|||.       ::.:|:|...|    ..|      ||..|.|:
Zfish   922 VPFQRAVSVDGKPMSGPGMTGRKSAPSSLVKQEHTDSQIGMGGPN------RLMGMPNR------ 974

  Fly  1474 RPPPM------------------YPARGRGPM--NAVATPGGVVLPAQQQL---RNIRQQQQLAA 1515
              |||                  :|..||..|  |..:..||.::.....:   |::.|||.:..
Zfish   975 --PPMAGAGDWMSSSGSPAGSVGHPGMGRPGMDHNPKSMMGGPMVSRSNSVPATRSMLQQQLMEM 1037

  Fly  1516 AQQKERLLQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNV 1580
            ......:.....:.|...|::.|  |.:|.:             ||.             |.|:.
Zfish  1038 GPYDVGMGMNSFRGQAPPPQSPS--WPDSGM-------------GME-------------GPPSA 1074

  Fly  1581 SLSRTNLPSDAQLSP---------------------NFAQTLMQQQLSPGRSAPYSPQPNQGYAP 1624
            :....|.|.|..|:|                     |....:..:::......|  ...|||::.
Zfish  1075 NRLPINSPLDELLAPPSTSEGQSDERALLDQLDSLLNNTDVIALEEIDRALGIP--DLINQGHSS 1137

  Fly  1625 QFPQPGQRLSPQQQQQLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQW 1689
            ..|.|.   .|.....|.......::..:..|.|              ...|..|.|||..   :
Zfish  1138 DQPPPS---DPFSGPCLGPDSSMGMEPPKAMYGQ--------------GYPGPPSMGMQGG---Y 1182

  Fly  1690 GSGGGGGGGPG-GPLPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGLNSPGAVGPGGN 1753
            |.|...|.||| ||                    :||.|                     |||.|
Zfish  1183 GPGPNPGAGPGPGP--------------------MQGQS---------------------GPGFN 1206

  Fly  1754 PAAQAALQRQNSFQGQGGGGATTPDGSGVGFGGPQSPYGTNVNVFQQQQLQRLQRQGSVPQATQH 1818
            | ..:.:.:|..|.|.||.|...|..:.:....||:      ...:.|..||||.|..:.|:.|.
Zfish  1207 P-MMSQMNQQGGFPGMGGMGPMHPRANMMRNRVPQA------KPLRLQLQQRLQGQQFLNQSRQA 1264

  Fly  1819 L-----------PG-----SPRFGSSPGSSN---NTDSSAAAGNQQQQQQQQQ--QQQQQHQQQQ 1862
            :           ||     .|..|..||..|   ....|....|.|.:.::|:  ...||.||||
Zfish  1265 MGMRPDASPAGNPGMRPSMQPGMGGQPGFLNAQMMAQRSREMLNLQTEMRRQRMMMMMQQQQQQQ 1329

  Fly  1863 HQQLMNGLSMSP---------HPHPHPAMMGVG----------GMGSGGGNGIIGLGGGGGN--Y 1906
            .|....|.|..|         :|...|.|...|          |:|..|....:|.|....|  .
Zfish  1330 QQVAAGGFSPPPNVTAPTGMDNPMAGPPMSQPGQQAFNYGGNYGIGQQGDPSFVGTGSSPPNNMM 1394

  Fly  1907 GATLGG-----YGQSQQANDFYGRAQTAGGGGSVAGGNANSEFV 1945
            ...:||     ..|..|:|..|..|:..|.|......|.:.|.|
Zfish  1395 SGRMGGPQNPMMQQHPQSNPMYQSAEMKGWGQGPMPMNNHPETV 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	21/56 (38%)
		PAS	377..442	CDD:214512	14/64 (22%)
		PAS_11	591..711	CDD:291273	26/131 (20%)
ncoa3	XP_021335474.1	HLH	32..85	CDD:197674	25/92 (27%)
		PAS	113..170	CDD:214512	16/88 (18%)
		PAS_3	256..367	CDD:330807	26/131 (20%)
		NCOA_u2	490..617	CDD:318802	32/157 (20%)
		SRC-1	663..773	CDD:312390	36/171 (21%)
		DUF4927	795..880	CDD:318508	13/121 (11%)
		Nuc_rec_co-act	1094..1141	CDD:312376	5/48 (10%)
		DUF1518	1348..1406	CDD:311422	12/57 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4291
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10684
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.980