DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and tgo

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	782	Identity:	153/782 - (19%)
Similarity:	228/782 - (29%)	Gaps:	292/782 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SQINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTST------KPDKAAILNQVVRTYREICDK 294
            |:.|.|..|:|||.....||.:||         ||..|      ||||..||...|...:.:...
  Fly    14 SRENHCEIERRRRNKMTAYITELS---------DMVPTCSALARKPDKLTILRMAVAHMKALRGT 69

  Fly   295 GQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEP 359
            |                     ||:|:...
  Fly    70 G---------------------NTSSDGTY----------------------------------- 78

  Fly   360 PLPEPSLLLGQVPEISAYFEALEHYI--SGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQ 422
               :||.|..|         .|:|.|  :..|::.:....:|.:...:.::..::.|.:.:.|..
  Fly    79 ---KPSFLTDQ---------ELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131

  Fly   423 PLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNA-SQG 486
            .||.:::..|..|:...::|.       .|.:|                 |.:.:|.:|.. .:|
  Fly   132 SLYEHIHPDDREKIREQLSTQ-------ESQNA-----------------GRILDLKSGTVKKEG 172

  Fly   487 SNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSNCEEKPLRQS---GHQDKYEEVV 548
            ..||....:|...|...          ||.|.:....:..|.:......|.|   ........||
  Fly   173 HQSSMRLSMGARRGFIC----------RMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVV 227

  Fly   549 LIAAPVKD--------------DADASSSVLCLI---------TRPEDESPLEINIQQHVQQQPI 590
            .....:|:              |.|..||..||:         |...|.|... |..:.:.:..:
  Fly   228 HCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSN-NQSEFITRHAM 291

  Fly   591 E-QMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDIQDSASANS 654
            : :.||.......||...||.|           :|::..|..||.|    :||:::..|......
  Fly   292 DGKFTFVDQRVLNILGYTPTEL-----------LGKICYDFFHPED----QSHMKESFDQVLKQK 341

  Fly   655 PGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGA 719
                  ..:.|..:|.|....: ||.::..:..|||....|.::|:..          |||  |.
  Fly   342 ------GQMFSLLYRARAKNSE-YVWLRTQAYAFLNPYTDEVEYIVCT----------NSS--GK 387

  Fly   720 GSGGLGLGQLCA-------------------MAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAA 765
            ...|..|....|                   .||....|...|           |..||:::
  Fly   388 TMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARREL-----------TPVGSATN--- 438

  Fly   766 SGMLPTHLLGGLV-------------GGGQQGGGGNSTQTT----SVGGPLMSSAI-INGTG--- 809
            .||..||:|....             |..|....|.:..||    |.|||...:.| .:||.
  Fly   439 DGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTP 503

  Fly   810 ----------LQQQQQQQQ----------------RSGASSSASSSAN-----ALVNAFTASPAP 843
                      .||||||||                .||.:.:..|:.|     |...|:.|.|.|
  Fly   504 VAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPP 568

  Fly   844 AEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCA 908
                                     |....|.|...:.........|.:.|..|..|...||...
  Fly   569 -------------------------PPNAPGMWDWQQAGGHPHPPHPTAHPHHPHAHPGGPAGAG 608

  Fly   909 SP 910
            .|
  Fly   609 QP 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	20/55 (36%)
		PAS	377..442	CDD:214512	11/66 (17%)
		PAS_11	591..711	CDD:291273	25/120 (21%)
tgo	NP_001262397.1	HLH	15..67	CDD:278439	20/60 (33%)
		PAS	87..192	CDD:279347	23/138 (17%)
		PAS	90..154	CDD:214512	11/70 (16%)
		PAS_11	283..384	CDD:291273	25/132 (19%)
		PAS	283..380	CDD:238075	24/118 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900