DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and ARNTL

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	XP_016873227.1	Gene:	ARNTL / 406	HGNCID:	701	Length:	674	Species:	Homo sapiens

Alignment Length:	779	Identity:	144/779 - (18%)
Similarity:	254/779 - (32%)	Gaps:	283/779 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 PISANSANSATSGRKIRRK-----TDSKVNLP---------------QSQINKCNN-----EKRR 247
            |....|::..|||....||     ||.:.::.               |.:|.....     ||||
Human    63 PTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRR 127

  Fly   248 REAENGYIEQLSEIL-TLNKRGDMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNST 311
            |:..|.:|::|:.:: |.|    ..|.|.||..:|...|:..:.:  :|
Human   128 RDKMNSFIDELASLVPTCN----AMSRKLDKLTVLRMAVQHMKTL--RG---------------- 170

  Fly   312 TTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISA 376
             .||..|.:|     .||...|.
Human   171 -ATNPYTEAN-----YKPTFLSD------------------------------------------ 187

  Fly   377 YFEALEHYI--SGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPI 439
              :.|:|.|  :..|::.:.....|.|...::::..::.|.:.:|..|.|:.||:..|.||::..
Human   188 --DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ 250

  Fly   440 INTMYNNPNGGNSNSANNSGPGGS--SAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAA 502
            :             |::::.|...  .|.|...|..|:..                   |.....
Human   251 L-------------SSSDTAPRERLIDAKTGLPVKTDITP-------------------GPSRLC 283

  Fly   503 AGKKRSISTKVR-----MLVKDTRTATQTSSNCEEK--------PLRQSGHQDKYEEVVLIAAPV 554
            :|.:||...:::     :.|:|    ....|.|.:|        .:..:|:...:       .|.
Human   284 SGARRSFFCRMKCNRPSVKVED----KDFPSTCSKKKADRKSFCTIHSTGYLKSW-------PPT 337

  Fly   555 K---------DDADASSSVLCLITRPEDESPLEINIQQHVQQQPIE--------QMTFKLDIHGK 602
            |         |:...:.|.|..|.|          :..||..||:.        :...:..|.||
Human   338 KMGLDEDNEPDNEGCNLSCLVAIGR----------LHSHVVPQPVNGEIRVKSMEYVSRHAIDGK 392

  Fly   603 ILTLD--PTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDI---QDSASANSPGAGAGTS 662
            .:.:|  .||:.....|.|   :|....:..|..|:..|....|.:   ::..:.|
Human   393 FVFVDQRATAILAYLPQEL---LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN--------- 445

  Fly   663 VVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSGGLGLG 727
              ...|:::.|:   ::.:::....|:|....|.::|:|..|::       .:|...| |.....
Human   446 --CYKFKIKDGS---FITLRSRWFSFMNPWTKEVEYIVSTNTVV-------LANVLEG-GDPTFP 497

  Fly   728 QLCAMAPSPSLASSLLSS--------------LSMDGLHGGTGSGS------------------S 760
            ||.|   ||....|:|.|              .::.|:.|||.:|:                  .
Human   498 QLTA---SPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRG 559

  Fly   761 SSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGP-LMSSAIINGTGLQQQQQQQQRSGASS 824
            |||::.|..|.::...........||   .:..:.|.| :.||.:::|       |.|:..|...
Human   560 SSPSSCGSSPLNITSTPPPDASSPGG---KKILNGGTPDIPSSGLLSG-------QAQENPGYPY 614

  Fly   825 SASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFE----------LDPSGGVGAWTD 878
            |.|||            ...|:...|.|..:.|..:.|.|.:          |:...|:|...|
Human   615 SDSSS------------ILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVD 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	17/56 (30%)
		PAS	377..442	CDD:214512	15/66 (23%)
		PAS_11	591..711	CDD:291273	22/132 (17%)
ARNTL	XP_016873227.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900