DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and ARNT

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	NP_001659.1	Gene:	ARNT / 405	HGNCID:	700	Length:	789	Species:	Homo sapiens

Alignment Length:	911	Identity:	178/911 - (19%)
Similarity:	281/911 - (30%)	Gaps:	296/911 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 KIRRKTDSKVNLPQSQINKCNN---EKRRREAENGYIEQLSEILTLNKRGDMTST------KPDK 277
            :..|..|.:.:..:.::.:.|:   |:|||.....||.:||         ||..|      ||||
Human    73 RFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELS---------DMVPTCSALARKPDK 128

  Fly   278 AAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATD 342
            ..||...|...:.:      |...:|||:.:.
Human   129 LTILRMAVSHMKSL------RGTGNTSTDGSY--------------------------------- 154

  Fly   343 NCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYI--SGVGWVLLQVNANGIIESCT 405
                                :||.|..|         .|:|.|  :..|::.:.....|.:...:
Human   155 --------------------KPSFLTDQ---------ELKHLILEAADGFLFIVSCETGRVVYVS 190

  Fly   406 QNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAG 470
            .::..::...:.|.:...||..::..|..||...::|..|                        .
Human   191 DSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSEN------------------------A 231

  Fly   471 VWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKV------RMLVKDTRTATQTSSN 529
            :.|.:.:|..|...:....|......|:..:...:.|..|:.|      |:.....|......|.
Human   232 LTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSV 296

  Fly   530 CEEKPLRQSGHQDKYEEV---VLIAAPVKDDADASSSVLCLIT--RPEDESPLEINIQQHVQQQP 589
            .:.:|.....|...|.:.   ..::.|..|......|..||:.  |.:..|........:| .||
Human   297 KDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQP 360

  Fly   590 IEQMTFKLDIHGKILTLD----PTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDIQDSA 650
            .|.:: :.:|.|....:|    .|...:|     |..:|:...:.|||.|...|:...:.:....
Human   361 TEFIS-RHNIEGIFTFVDHRCVATVGYQP-----QELLGKNIVEFCHPEDQQLLRDSFQQVVKLK 419

  Fly   651 SANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSS 715
            .          .|:|..||.| .....::.::.:|..|.|....|.::|:...|     |..|||
Human   420 G----------QVLSVMFRFR-SKNQEWLWMRTSSFTFQNPYSDEIEYIICTNT-----NVKNSS 468

  Fly   716 NTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGG 780
                            ..|.|:|::::              ......|.|:  ||..:..|.:..
Human   469 ----------------QEPRPTLSNTI--------------QRPQLGPTAN--LPLEMGSGQLAP 501

  Fly   781 GQQ----------GGGGNST-------QTTSVGGPLMSSAIINGTGLQQQQQQ------------ 816
            .||          |..|.::       |..:..||..|..:....||..|.:.
Human   502 RQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINA 566

  Fly   817 QQRSGASSSASSSANALV---NAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTD 878
            .|..|.|||...:...|.   |.|..:|.||| :|..|     .:|...:..:...|.|......
Human   567 DQSKGISSSTVPATQQLFSQGNTFPPTPRPAE-NFRNS-----GLAPPVTIVQPSASAGQMLAQI 625

  Fly   879 SRPNSRASVATPVSTPRPPSGHGFSPAVCASPA---------------TPYQLSSHSAASLPSPQ 928
            ||.::....|||..||...|  |||....|:.|               ||...||.|....|:..
Human   626 SRHSNPTQGATPTWTPTTRS--GFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTAS 688

  Fly   929 SNASA------GGGNY--------GGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNSSSSNPLLGG 979
            ..|:|      .|.|:        |.|...:.:...|.|     |.|.||..:.:|||
Human   689 PGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWP-----QWQGQQPHHRSSSS------- 741

  Fly   980 GLPNGVGGMLLSQQQQQQQTPPQQQQQQQQ--QESSERLRHLLTKSQSMAGGLGGLGDDEKYFKP 1042
                          :|..|.||.||..|.:  ||.                 |..|||....:..
Human   742 --------------EQHVQQPPAQQPGQPEVFQEM-----------------LSMLGDQSNSYNN 775

  Fly  1043 E 1043
            |
Human   776 E 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	18/59 (31%)
		PAS	377..442	CDD:214512	11/66 (17%)
		PAS_11	591..711	CDD:291273	24/123 (20%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		3/23 (13%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:28396409	88..128		14/48 (29%)
		HLH	91..143	CDD:278439	19/66 (29%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		38/252 (15%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		22/132 (17%)
		PAS	163..269	CDD:279347	18/129 (14%)
		PAS	166..230	CDD:214512	11/63 (17%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		1/3 (33%)
		PAS_11	362..462	CDD:291273	23/116 (20%)
		PAS	362..458	CDD:238075	22/112 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..492		9/58 (16%)
		Med3	<523..>734	CDD:288447	54/223 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..789		35/148 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900