Protein Alignment tai and Ncoa1

DIOPT Version :10

• Sequence 1: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Sequence 2: XP_017449617.1
• Gene: Ncoa1 / 313929
• RGDID: 1309046
• Length: 1443
• Species: Rattus norvegicus
• Alignment Length: 1814
• Identity: 371/1814 - (20%)
• Similarity: 600/1814 - (33%)
• Gaps: 603/1814 - (33%)

  Fly   242 NNEKRRREAENGYIEQLSEILTLNKRG-DMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTST 305
            :.||||||.||.|:|:|:|:|:.|... |..|.||||..||.:.|             |......
  Rat    30 STEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTV-------------DQIQLMK 81

  Fly   306 NNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPE-----PS 365
            ......:||:::                               ||:.::||:...:.|     |.
  Rat    82 RMEQEKSTTDDD-------------------------------VQKSDISSSSQGVIEKESLGPL 115

  Fly   366 LLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYS 430
            ||           |||:.:       ...||..|.|...::|:...:||.::||.:..:|..|:.
  Rat   116 LL-----------EALDGF-------FFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHV 162

  Fly   431 GDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGL 495
            ||||  |.:.|.:        ..|..|..|           |..
  Rat   163 GDHA--EFVKNLL--------PKSLVNGVP-----------WPQ--------------------- 185

  Fly   496 GGAGGAAAGKKRSISTKVRMLV-KDTRTATQTSSNCEEKPLRQSGHQDKYE--EVVLIAAP--VK 555
                  .|.::.|.:...|||: ......|:....|:           :||  :...::.|  ::
  Rat   186 ------EATRRNSHTFNCRMLIHPPDEPGTENQEACQ-----------RYEVMQCFTVSQPKSIQ 233

  Fly   556 DDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQ 620
            :|.:...|.|..|.|.....|....::..:.:|         |..|||:::|.::||.
  Rat   234 EDGEDFQSCLICIARRLPRPPAITGVESFMTKQ---------DTTGKIISIDTSSLRA------- 282

  Fly   621 TWVGRL-WQDLCHP----------HDLSTLKSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGA 674
              .||. |:||...          .:.|..:...:::....:|:||         |..|.|..|.
  Rat   283 --AGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSP---------SYRFILNDGT 336

  Fly   675 PDVYVHVKANSRLFLNQTPGEGDFIMSVQTL------LNSENDMNSS----------NTGAGSGG 723
            . :..|.|.  :|...|:|....|||.:..:      |:.::|.||.          |.|. |..
  Rat   337 M-LSAHTKC--KLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGI-SPA 397

  Fly   724 LGLGQLCAMAPS-PSLASSLLSSLSMDGLHGGTG-SGSSSSPAASGMLPTHLLGGLVGGGQQGGG 786
            .|:.:...:.|| .::.|:..:......|:.|:. |.||||..:.|..|.:.:...| ...||..
  Rat   398 HGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASV-ALSQGQA 461

  Fly   787 GNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGS 851
            |:.:...|:.   ::::.:.|||:...|....|..|:|..::.|....|:|..: .|...|..|.
  Rat   462 GSQSSNPSLN---LNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNSFPPN-IPTLSSPVGI 522

  Fly   852 DTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPR-----PPSGHGFSPAVCASPA 911
            .:                    ||.::   |:|:....||::.:     |.:..|||   ..||.
  Rat   523 TS--------------------GACSN---NNRSYSNIPVTSLQGMNEGPNNSVGFS---AGSPV 561

  Fly   912 TPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQNQQ-QSNNNSSSSNP 975
            .....|.:|.:.|....:.|.:                  |..|::....|:. ||:|:::...|
  Rat   562 LRQMSSQNSPSRLSMQPAKAES------------------KDNKEIASILNEMIQSDNSANEGKP 608

  Fly   976 LLGGGLPN----GVGGMLLSQQQQQ--QQTPPQQQQQQQQQESSERLRHLL----TKSQSMAGGL 1030
            |..|.|.|    ..|....||...:  |......:||.:..:.....:.:|    |.|.:.:...
  Rat   609 LDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPS 673

  Fly  1031 GGLGDDEKYFKPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLL 1095
            ||.....     ..|..|:|                              .:||:.....:|..:
  Rat   674 GGTCPSS-----HSSLTERH------------------------------KILHRLLQEGSPSDI 703

  Fly  1096 KLLNEKSEDDDG---------NGSGGGPGSM---------NNSRQSELMRQLKNPDGGSHGMHRN 1142
            ..|:.:.|..|.         :|...|..|:         ..|:..:|:|.|.:.|...     .
  Rat   704 TTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDASKKKESKDHQLLRYLLDKDEKD-----L 763

  Fly  1143 SASGNMSTEDLKAML--KIQSDPSLNRKRSLNEPDDD---------------------PSAKRSE 1184
            .::.|:|.:|:|..:  |.|.||.......:.:|..:                     |:.:::.
  Rat   764 RSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAA 828

  Fly  1185 DKPSKLCTQNKM---------LAKLLQNPPKIPKAPNPEQPLQVKTLPDITSSTVSSTLAAPGNL 1240
            ..|. ||..::|         .:::|  |..:...|....| ::..||::....:.:....||
  Rat   829 QLPG-LCETDRMDGAVPGVNIKSEIL--PASLQPTPARSAP-RLNRLPELELEAIDNQFGQPG-- 887

  Fly  1241 ISAGSTGPKAAANRNRKQQQQQQQQQQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLA 1305
              ||...|.|                    ...|..|    .|.:|.|..:|.|..:.|..|
  Rat   888 --AGDQIPWA--------------------NNTVTAI----NQSKPEDQCISSQLDELLCPP--- 923

  Fly  1306 FQHQQLATTATTSITTAASTSAAAAAAAAIL-GEGDSELSKL--------------LDSVMEYYP 1355
                       |::.......|......:.| |:.::||::|              ||.:.|.:|
  Rat   924 -----------TTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFP 977

  Fly  1356 ----------DDTPIV----TNAPSEASAINDIQKSLMLDVESAAFGNDLNQQLMMTQQQQHQQQ 1406
                      :|.|.:    .::||..:.:            |..|      |.|:.|:......
  Rat   978 PQQATPPLMMEDRPTLYPQPYSSPSPTAGL------------SGPF------QGMVRQKPSLGTM 1024

  Fly  1407 QQQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQ----QNQQHIMQRLEAMRNQ 1467
            ..|........:.....|.:|.|.:|||.|..|.:|.||..|.||    ||:|.|:.:..|....
  Rat  1025 PVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPV 1089

  Fly  1468 G---NQGFQR---PPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQQKERLLQQQ 1526
            |   ..|.|:   |.|        |:||            |.|  .::|::|.:.|.::|.:.||
  Rat  1090 GMNMRSGMQQQITPQP--------PLNA------------QML--AQRQRELYSQQHRQRQIIQQ 1132

  Fly  1527 QKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSLSRTNLPSDA 1591
            |:..|:    ..:.:||                          ::..::|.| |.:....||..|
  Rat  1133 QRAMLM----RHQSFGN--------------------------NIPPSSGLP-VQMGNPRLPQGA 1166

  Fly  1592 ----QLSPNF--------AQTLMQQQL--SPGRS-APYSPQPNQGYAPQF-PQPGQRLSPQQQQQ 1640
                ...||:        |.|....||  :|..| |..|...|:|.|... .|.|..:|||.||.
  Rat  1167 PQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGTGISPQMQQN 1231

  Fly  1641 LSQQQQNNVQQQQLAYQQQQVGDGGR-------------SNTPFGSNSGMQSPGMQNSPQQWGSG 1692
            :.|...:.:..|..|.....:..|..             ..||  ..||.|||.|    :.|..|
  Rat  1232 VFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQSSLLQQTP--PTSGYQSPDM----KAWQQG 1290

  Fly  1693 GGGGG-----------GPGGP-----------LPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQ 1735
            ..|..           .|..|           :..|||  .:|..|||:               .
  Rat  1291 TMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNA--NVQNMNPMM---------------G 1338

  Fly  1736 QNQRRGLNSPGAVGPGGNPAAQAALQRQNSFQGQGGGG---ATTPDGSGVGFGGPQSPYGTNVNV 1797
            |.|...|..||............||:....:..|....   .|..||:
  Rat  1339 QMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTEADGN----------------- 1386

  Fly  1798 FQQQQLQRLQRQGSVPQATQHLPGSPRFGSSPGSSNNTDSSAAAGNQQQQQQQQQQQQQ 1856
               ||:|:||....| |.|.:|.|...:.:.||....  ....:|.|..|.||:...||
  Rat  1387 ---QQVQQLQVFADV-QCTVNLVGGDPYLNQPGPLGT--QKPTSGPQTPQAQQKSLLQQ 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	bHLH_SF	239..291	CDD:469605	23/49 (47%)
		PAS	377..442	CDD:214512	19/64 (30%)
		PAS_11	590..711	CDD:464214	29/137 (21%)
Ncoa1	XP_017449617.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	24/69 (35%)
		PAS	120..213	CDD:238075	28/147 (19%)
		PAS_11	259..370	CDD:464214	29/140 (21%)
		NCOA_u2	469..591	CDD:465223	32/169 (19%)
		SRC-1	630..709	CDD:462615	15/113 (13%)
		DUF4927	744..821	CDD:465083	14/81 (17%)
		Nuc_rec_co-act	927..972	CDD:462608	8/44 (18%)
		Med15	<977..>1289	CDD:312941	89/388 (23%)
		DUF1518	1152..1208	CDD:462174	16/56 (29%)
		DUF1518	1215..1270	CDD:462174	11/54 (20%)