DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and Arntl2

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	XP_006507111.1	Gene:	Arntl2 / 272322	MGIID:	2684845	Length:	595	Species:	Mus musculus

Alignment Length:	742	Identity:	145/742 - (19%)
Similarity:	252/742 - (33%)	Gaps:	259/742 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 NAVASPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKR 267
            |..||.:|..:..||.||          :....||:     |||||:..|..|::||.::..:
Mouse    31 NPFASLLSTRTGVSAPSG----------IREAHSQM-----EKRRRDKMNHLIQKLSSMIPPH-- 78

  Fly   268 GDMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQAT 332
             ..|:.|.||.::|.:.|:..|.:      |.::......|                  |||..
Mouse    79 -IPTAHKLDKLSVLRRAVQYLRSL------RGMTELYLGEN------------------SKPSF- 117

  Fly   333 STRCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNA 397
                            :|..|:|         .|:|          :|.|.::..||.      .
Mouse   118 ----------------IQDKELS---------HLIL----------KAAEGFLFVVGC------E 141

  Fly   398 NGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKL------------EPI---INTMYNNP 447
            .|.|...::::...:.|::..|..|.|:.:|:..|.||:            :||   .:.:|::|
Mouse   142 RGRIFYVSKSVSKTLRYDQASLIGQNLFDFLHPKDVAKVKEQLSCDGSPREKPIDTKTSQVYSHP 206

  Fly   448 NGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTK 512
            ..|...                                               ..:|.:||...:
Mouse   207 YTGRPR-----------------------------------------------MHSGSRRSFFFR 224

  Fly   513 VR---MLVKDTRTATQTSSNCEEK------------------PLRQSGHQDKYEEVVLIAAPVKD 556
            ::   :.||:    .|..|:|.:|                  ||...|.:.:       :...||
Mouse   225 MKSCTVPVKE----EQPCSSCSKKKDHRKFHTVHCTGYLRSWPLNVVGMEKE-------SGGGKD 278

  Fly   557 DADASSSVLCLITR--------PEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLD--PTAL 611
                |..:.||:..        |:...  :||:      :|.|.:| :..::||.:.:|  .||:
Mouse   279 ----SGPLTCLVAMGRLHPYIVPQKSG--KINV------RPAEFIT-RFAMNGKFVYVDQRATAI 330

  Fly   612 REPFKQHLQTWVGRLWQDLCHPHDLSTL-KSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAP 675
            .....|.|   :|....:..|..|.|:| ..|...:|......:.         |..||::.||
Mouse   331 LGYLPQEL---LGTSCYEYFHQDDHSSLTDKHKAVLQSKEKILTD---------SYKFRVKDGA- 382

  Fly   676 DVYVHVKANSRLFLNQTPGEGDFIMSVQTLL--NSENDMN------SSNTGAGSGGLGLGQLCAM 732
              :|.:|:....|.|....|.::|:||.||:  .||..::      ||.:..|...|.:.:..:.
Mouse   383 --FVTLKSEWFSFTNPWTKELEYIVSVNTLVLGRSETRLSLLHCGGSSQSSEGKTELQVRRGNSD 445

  Fly   733 APSPSLASSLLSSLSMDGLHGGT--GSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSV 795
            |.|.|...   |.:::.|:..||  |:||..:..|:.:|....|           ..:|.:..|.
Mouse   446 ASSDSFRQ---SCINVPGVSTGTVLGAGSIGTDIANEVLSLQRL-----------HSSSPEDASP 496

  Fly   796 GGPLMSSAIINGTGLQQQQQQQQRSGASSS------ASSSANALVNAFTASPAPAEHSFYGSDTF 854
            ...:.....:||.........::....|.|      |:....:...|....|.|.:.:..|
Mouse   497 SEEVRDDCSVNGGNAYGPASTREPFAVSPSETEVLEAARQHQSTEPAHPHGPLPGDSAQLG---- 557

  Fly   855 EFDIAAHSSSFE-------LDPSGGVG 874
             ||:...|.|.:       |:..||:|
Mouse   558 -FDVLCDSDSIDMAAFMNYLEAEGGLG 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	16/50 (32%)
		PAS	377..442	CDD:214512	16/79 (20%)
		PAS_11	591..711	CDD:291273	33/124 (27%)
Arntl2	XP_006507111.1	bHLH_SF	49..108	CDD:381792	19/72 (26%)
		PAS	125..184	CDD:214512	16/74 (22%)
		PAS_11	309..411	CDD:373151	30/117 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900