DRSC/TRiP Functional Genomics Resources

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Protein Alignment tai and Arnt

DIOPT Version :10

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:NP_036912.3 Gene:Arnt / 25242 RGDID:2153 Length:809 Species:Rattus norvegicus


Alignment Length:930 Identity:177/930 - (19%)
Similarity:283/930 - (30%) Gaps:314/930 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   222 KIRRKTDSKVNLPQSQINKCNN---EKRRREAENGYIEQLSEILTLNKRGDMTST------KPDK 277
            :..|..|.:.:..:.::.:.|:   |:|||.....||.:||         ||..|      ||||
  Rat    73 RFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELS---------DMVPTCSALARKPDK 128

  Fly   278 AAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATD 342
            ..||...|...:.:      |...:|||:.:.                                 
  Rat   129 LTILRMAVSHMKSL------RGTGNTSTDGSY--------------------------------- 154

  Fly   343 NCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYI--SGVGWVLLQVNANGIIESCT 405
                                :||.|..|         .|:|.|  :..|::.:.....|.:...:
  Rat   155 --------------------KPSFLTDQ---------ELKHLILEAADGFLFIVSCETGRVVYVS 190

  Fly   406 QNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAG 470
            .::..::...:.|.:...||..::..|..||...::|..|                        .
  Rat   191 DSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSEN------------------------A 231

  Fly   471 VWGDLEELNNGNA-SQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSN----- 529
            :.|.:.:|..|.. .:|..||..        ...|.:||...::|.   .|.:....|.|     
  Rat   232 LTGRILDLKTGTVKKEGQQSSMR--------MCMGSRRSFICRMRC---GTSSVDPVSMNRLSFL 285

  Fly   530 ---C--------EEKPLRQSGHQDKYEEV---VLIAAPVKDDADASSSVLCLIT--RPEDESPLE 578
               |        |.:|.....|...|.:.   ..::.|..|......|..||:.  |.:..|...
  Rat   286 RNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPN 350

  Fly   579 INIQQHVQQQPIEQMTFKLDIHGKILTLD----PTALREPFKQHLQTWVGRLWQDLCHPHDLSTL 639
            .....:: .||.|.:: :.:|.|....:|    .|...:|     |..:|:...:.|||.|...|
  Rat   351 CTDMSNI-CQPTEFIS-RHNIEGIFTFVDHRCVATVGYQP-----QELLGKNIVEFCHPEDQQLL 408

  Fly   640 KSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQT 704
            :...:.:.....          .|:|..||.|....: ::.::.:|..|.|....|.::|:...|
  Rat   409 RDSFQQVVKLKG----------QVLSVMFRFRAKNRE-WLWMRTSSFTFQNPYSDEIEYIICTNT 462

  Fly   705 LLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSL----LSSLSMDGLHGGTGSGSS----- 760
                 |..|||                ..|.|:|::::    |...:...|..|||..:|     
  Rat   463 -----NVKNSS----------------QEPRPTLSNTIQRSQLGPTTNLSLEMGTGQLASRQQQQ 506

  Fly   761 ------------------SSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIING 807
                              .......|:|     |..|.........|.|..:..|...|..:...
  Rat   507 QQQQQQQQQQQQQQQQQQQQQTELDMVP-----GRDGLASYSHSQVSVQPVATAGSEHSKPLEKS 566

  Fly   808 TGLQQQQQQ------------QQRSGASSSASSSANALV---NAFTASPAPAEHSFYGSDTFEFD 857
            .||..|.:.            .|..|.|||...:...|.   ::|..:|.|||:......|....
  Rat   567 EGLFVQDRDPRFSEIYPNISADQSKGLSSSTVPATQQLFSQGSSFPPNPRPAENFRNSGLTPPVT 631

  Fly   858 IAAHSSSFELDPSGGVGAWTDSRPN-SRASVATPVSTPRPPSGHGFS---PAVCASPATPYQL-- 916
            |...|||     :|.:.|......| ::.|..|..|:.||    |||   |....:.....|.  
  Rat   632 IVQPSSS-----AGQILAQISRHSNLTQGSAPTWTSSTRP----GFSAQLPTQATAKTRSSQFGV 687

  Fly   917 ------SSHSAASLP-SPQSNASAG--------GGNY--------GGFNFHSFDSSDVKPEKDVQ 958
                  ||.||.||| :|.::.|..        |.|:        |.|...:.:...|.|     
  Rat   688 NNFQTSSSFSAMSLPGAPTASPSTAAYPTLPNRGSNFPPETGQTTGQFQTRTAEGVGVWP----- 747

  Fly   959 QQQNQQQSNNNSSSSNPLLGGGLPNGVGGMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLLTKS 1023
            |.|.||..:.:||:                       :|...|...|...|.|..:.:       
  Rat   748 QWQGQQPHHRSSSN-----------------------EQHVQPTSAQPSSQPEVFQEM------- 782

  Fly  1024 QSMAGGLGGLGDDEKYFKPE 1043
                  |..|||....:..|
  Rat   783 ------LSMLGDQSNTYNNE 796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 bHLH_SF 239..291 CDD:469605 19/60 (32%)
PAS 377..442 CDD:214512 11/66 (17%)
PAS_11 590..711 CDD:464214 24/124 (19%)
ArntNP_036912.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..95 3/21 (14%)
bHLH-PAS_ARNT 86..150 CDD:381517 21/78 (27%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P53762 88..128 14/48 (29%)
Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762 112..264 42/260 (16%)
Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762 112..168 22/132 (17%)
PAS 163..269 CDD:395786 22/137 (16%)
Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762 167..171 1/3 (33%)
PAS_11 362..462 CDD:464214 23/116 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..487 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..575 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..685 9/35 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..735 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..809 16/85 (19%)
Blue background indicates that the domain is not in the aligned region.

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