DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and Npas2

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	NP_032745.2	Gene:	Npas2 / 18143	MGIID:	109232	Length:	816	Species:	Mus musculus

Alignment Length:	1180	Identity:	212/1180 - (17%)
Similarity:	339/1180 - (28%)	Gaps:	506/1180 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 DSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTSTKPDKAAILNQV-------- 284
            |.|....::..||  :||:||:..|..|::||.:|..|.|      |.||..:|.:|
Mouse     4 DEKDRAKRASRNK--SEKKRRDQFNVLIKELSSMLPGNTR------KMDKTTVLEKVIGFLQKHN 60

  Fly   285 -VRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHP 348
             |....||||..|  |...:..:|...|
Mouse    61 EVSAQTEICDIQQ--DWKPSFLSNEEFT------------------------------------- 86

  Fly   349 VQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIG 413
                            .|:|          |||:      |:|:: |..:|.|...:.:|..|:|
Mouse    87 ----------------QLML----------EALD------GFVIV-VTTDGSIIYVSDSITPLLG 118

  Fly   414 YEKQELYHQPLYMYLYSGDHAKLEPIINT---MYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDL 475
            :...::..|.|..:|...:|:::..|:::   :.::|:.....|.|                 ||
Mouse   119 HLPADVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEFLKSDN-----------------DL 166

  Fly   476 E---ELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQT-SSNCE--EKP 534
            |   .|..|:.:                    .|...:.:....|.:.|:.... |.:|.  :..
Mouse   167 EFYCHLLRGSLN--------------------PKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNT 211

  Fly   535 LRQSGHQDKYEEVVLIAAPVKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDI 599
            |.:..|           .|:..|       :|.|......:|..:. :..|..:|:|:.|.:..:
Mouse   212 LSRPCH-----------VPLGKD-------VCFIATVRLATPQFLK-EMCVADEPLEEFTSRHSL 257

  Fly   600 HGKILTLD----PTALREPFKQHLQTWVGRLWQDLCHPHDLSTL---KSHLRDIQDSASANSPGA 657
            ..|.|.||    |.....||:.     :|....|..|..||..|   ..||...
Mouse   258 EWKFLFLDHRAPPIIGYLPFEV-----LGTSGYDYYHIDDLELLARCHQHLMQF----------- 306

  Fly   658 GAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSG 722
            |.|.|...|    .|.....::.::.:..:..:|...:.:||:...::: |..|:.......
Mouse   307 GKGKSCCYR----FLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVV-SYADVRVERRQE--- 363

  Fly   723 GLGLGQLCAMAPSPSLASSLLSSL-------SMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGG 780
             |.|......|..||......|||       ::|  .|.:|..||.||:||
Mouse   364 -LALEDPPTEAMHPSAVKEKDSSLEPPQPFNALD--MGASGLPSSPSPSAS-------------- 411

  Fly   781 GQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAP-- 843
                                                      |.|:..|::..::..|::|..
Mouse   412 ------------------------------------------SRSSHKSSHTAMSEPTSTPTKLM 434

  Fly   844 AEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCA 908
            ||                                    ||..::..|.:.|:.....|.|.|...
Mouse   435 AE------------------------------------NSTTALPRPATLPQELPVQGLSQAATM 463

  Fly   909 SPATPYQLSSHSAASL-------------------PSPQSNASAGGGNYGGFNFHSFDSSDVKPE 954
            ..|.      ||:||.                   |:|.:..||        .|..|.:...:.|
Mouse   464 PTAL------HSSASCDLTKQLLLQSLPQTGLQSPPAPVTQFSA--------QFSMFQTIKDQLE 514

  Fly   955 K-------DVQQQQNQ-----------QQSN------------NNSSSSNPLLGGGLPNGVGGML 989
            :       :::.||.:           |.||            :.||:..|
Mouse   515 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRP-------------- 565

  Fly   990 LSQQQQQQQTPPQQQQQQ-------QQQESSERL--RHLLTKSQSMAGGLGGLGDDEKYFKPEGS 1045
             :.|||.||.|....|.|       |.|.:|.::  :|||.:|..:
Mouse   566 -AAQQQLQQRPAAPSQPQLVVNTPLQGQITSTQVTNQHLLRESNVI------------------- 610

  Fly  1046 EEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSEDDDGNGS 1110
                                                                            |
Mouse   611 ----------------------------------------------------------------S 611

  Fly  1111 GGGPGSMNNSRQSELMRQLKNPDGGSHGMHRNSASGNMSTEDLKAMLKIQSD---PSLNRKRSLN 1172
            ..||..|   |.|:|:                .|||. |...|.:.....:.   |.|:......
Mouse   612 AQGPKPM---RSSQLL----------------PASGR-SLSSLPSQFSSTASVLPPGLSLTTIAP 656

  Fly  1173 EPDDDPSAKRSEDKPSKLCTQNKMLAKLLQNP--PKIPKAPNPEQPLQVK-------------TL 1222
            .|.||     |:.:||.....::.|..||..|  |.:|.:.:..||.:|.             ..
Mouse   657 TPQDD-----SQCQPSPDFGHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQVMF 716

  Fly  1223 PDITSSTVSSTLAAPGNLISAGSTGPKAAANRNRKQQQQQQQQQQQQQQQQVAGIPSQQQQQQPN 1287
            |...|...:|:.:.|..|:......|...|:|....|..|.|||.....|    .|:....:||:
Mouse   717 PSPDSHPTNSSASTPVLLMGQAVLHPSFPASRPSPLQPAQAQQQPPPYLQ----APTSLHSEQPD 777

  Fly  1288 DVYLSQQQQQ 1297
            .:.||...||
Mouse   778 SLLLSTFSQQ 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	18/59 (31%)
		PAS	377..442	CDD:214512	16/64 (25%)
		PAS_11	591..711	CDD:291273	26/126 (21%)
Npas2	NP_032745.2	bHLH-PAS_NPAS2_PASD4	1..77	CDD:381580	27/82 (33%)
		Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPH. /evidence=ECO:0000269\|PubMed:23831463	1..61		20/64 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		6/18 (33%)
		PAS	84..195	CDD:366402	29/217 (13%)
		PAS_11	249..352	CDD:373151	25/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..431		21/124 (17%)
		omega_3_PfaA	<440..>740	CDD:274311	74/436 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..639		12/131 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..705		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..816		16/50 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900