DRSC/TRiP Functional Genomics Resources

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Protein Alignment tai and Ncoa2

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:XP_017174718.1 Gene:Ncoa2 / 17978 MGIID:1276533 Length:1517 Species:Mus musculus


Alignment Length:1893 Identity:386/1893 - (20%)
Similarity:599/1893 - (31%) Gaps:671/1893 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 ISANSANSATSGR-KIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRG-DMT 271
            :|....|::...| :.|::.:....|..|.  |.:.|||.||.||.|||:|:|::..|... |..
Mouse     1 MSGMGENTSDPSRAETRKRKECPDQLGPSP--KRSTEKRNREQENKYIEELAELIFANFNDIDNF 63

  Fly   272 STKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRC 336
            :.||||.|||.:.|:..|:|  |.|.:..::                                  
Mouse    64 NFKPDKCAILKETVKQIRQI--KEQEKAAAA---------------------------------- 92

  Fly   337 SRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGII 401
                    :|..||:.:||||...:.:.. .||.:     ..|||:.:       ...||..|.:
Mouse    93 --------NIDEVQKSDVSSTGQGVIDKD-ALGPM-----MLEALDGF-------FFVVNLEGSV 136

  Fly   402 ESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAK----LEPIINTMYNNPNGGNSNSANNSGPGG 462
            ...::|:...:.|.::||.::.:|..|:.|||.:    |.|  .:|.|               ||
Mouse   137 VFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLP--KSMVN---------------GG 184

  Fly   463 SSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTS 527
            |.:|...                                   ::.|.:...|||||....:.:..
Mouse   185 SWSGEPP-----------------------------------RRSSHTFNCRMLVKPLPDSEEEG 214

  Fly   528 SNCEEKPLRQSGHQDKYEEVVLIAA----PVKDDA-DASSSVLCLITR-PEDESPLEINIQQHVQ 586
            .:.:|      .|| |||.:...|.    .:|::. |..|.::|:..| |..|.|         .
Mouse   215 HDSQE------AHQ-KYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERP---------T 263

  Fly   587 QQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHD---LSTLKSHLRDIQD 648
            ....|..|.:.|:.|||.:||.:.:|...|...:..|.|..|.....|:   ||..|.|..::..
Mouse   264 LPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLR 328

  Fly   649 SASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMN 713
            ...|           .|:.:|..| :....|..:..|:|..:||..|...::|:..|...:|   
Mouse   329 QGLA-----------FSQIYRFSL-SDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN--- 378

  Fly   714 SSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLV 778
                           :|.|.|..:                |...|...:|.:|.. |.|      
Mouse   379 ---------------VCVMNPDLT----------------GQAMGKPLNPISSSS-PAH------ 405

  Fly   779 GGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAP 843
               |....||..|..::|..:  :..:||. .:|......|.|.|...:.     |:...|:   
Mouse   406 ---QALCSGNPGQDMTLGSNI--NFPMNGP-KEQMGMPMGRFGGSGGMNH-----VSGMQAT--- 456

  Fly   844 AEHSFYGSDTFEFDIAAHSSSFEL---DPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPA 905
                           ....|::.|   .||       .|.|......|:.|.:||    ...||.
Mouse   457 ---------------TPQGSNYALKMNSPS-------QSSPGMNPGQASSVLSPR----QRMSPG 495

  Fly   906 VCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNS 970
            |..||..|....| .|.||.||....|:.|      |.||:.:|.:...:.:  .:....|..:|
Mouse   496 VAGSPRIPPSQFS-PAGSLHSPVGVCSSTG------NSHSYTNSSLNALQAL--SEGHGVSLGSS 551

  Fly   971 SSSNPLLGGGLPNGVGGMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLLTKSQSMAGGLGGLGD 1035
            .:|..|..|.|.|....|          .||.                 |:|..|:         
Mouse   552 LASPDLKMGNLQNSPVNM----------NPPP-----------------LSKMGSL--------- 580

  Fly  1036 DEK-----YFKP-EGSEEEKHASGGFKMGGQPGGMGMFGPMGSMG-RGVGNSSMLHKAGNSQNPM 1093
            |.|     |.:| ||:..:..||...:....|....|  |..:.| |..|:|.:....|.::   
Mouse   581 DSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSM--PQAASGDRAEGHSRLHDSKGQTK--- 640

  Fly  1094 LLKLLNEKSE--------------DDDGNGSGGGPGSMNNSRQSE-------LMRQLKNP----- 1132
            ||:||..||:              :.|..||..||||.:.:...|       |::...:|     
Mouse   641 LLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAK 705

  Fly  1133 ------------------DGGSHGMHRNSASGN----------MSTEDLKAM-----------LK 1158
                              .|....:.:..||..          :..:|.|.:           |.
Mouse   706 LTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLD 770

  Fly  1159 IQSDPSLNRK----RSLN-----EPDDDPSAKRSEDKPSKLCTQNKMLAKLLQN----------- 1203
            .::||:.|.|    :::.     ||.|.|.::....:......||..|.:|..:           
Mouse   771 SKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVD 835

  Fly  1204 -------------------PPKIPKA---------------------PNPEQPLQVKTL------ 1222
                               |....||                     ||...||.: ||      
Mouse   836 KQAIINDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDI-TLQSPTGA 899

  Fly  1223 ---PDITSSTVSSTLAAPGNLISAG-----------STG-----------------PKAAANR-- 1254
               |.|.:|:..|.:..||.:.:.|           |||                 |::.|.|  
Mouse   900 GPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPAVRVT 964

  Fly  1255 --------NRKQQ--------------QQQQQQQQQQQQQQVAGI-PSQQQQQQPNDVYLSQQQQ 1296
                    ||..|              ...|..|:|..|.||..| ||:.:.......|..||..
Mouse   965 CAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGPQYNQQQAP 1029

  Fly  1297 QQLQSP---------QLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSVME 1352
            ....:|         |.:|..|...:.......::.........||    |..|:...|||.:  
Mouse  1030 PNQTAPWPESILPIDQASFASQNSLSLYRQPFGSSPDDLLCPHPAA----ESPSDEGALLDQL-- 1088

  Fly  1353 YYP----------DDTPIVTNAPSEASAINDIQ-----KSLMLDVESAAFGNDLNQQLMMTQQQQ 1402
            |..          |....:....|::.|::..|     .|:||:.:...|......|..|.|...
Mouse  1089 YLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQGGY 1153

  Fly  1403 HQQQQQQQQLLALQLAQQQQQQRQQHLQQPPA---------YPGMLNMQQQQHQQQQQQNQQHIM 1458
            :..|......:.     |:.......:|..|.         .|..|.: |.||:.|.|||:|.:|
Mouse  1154 NPMQDPNFHTMG-----QRPNYTTLRMQPRPGLRPTGIVQNQPNQLRL-QLQHRLQAQQNRQPLM 1212

  Fly  1459 QRLEAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRN---IRQQQQLAAAQQKE 1520
            .::.::.|                    :|....||   :|.|..:..   .::|:::.....::
Mouse  1213 NQISSVSN--------------------VNLTLRPG---VPTQAPINAQMLAQRQREILNQHLRQ 1254

  Fly  1521 RLLQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSLSRT 1585
            |.:|||.:|:.|                        ::.|.  |||...|::...|.| .::|..
Mouse  1255 RQMQQQVQQRTL------------------------MMRGQ--GLNVTPSMVAPAGLP-AAMSNP 1292

  Fly  1586 NLP-SDAQ---LSPNFAQTLMQQQLSPGRSAPYSPQPNQGY----APQFPQPGQRLSPQQQQQLS 1642
            .:| ::||   ..||:.               .|.||:.|:    .||.|....|::..|...:.
Mouse  1293 RIPQANAQQFPFPPNYG---------------ISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQ 1342

  Fly  1643 QQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGGGGGG---GPGGPLP 1704
            |.|.|.      |||            |....:|            |..|..||.   ....|..
Mouse  1343 QSQANP------AYQ------------PTSDMNG------------WAQGSMGGNSMFSQQSPPH 1377

  Fly  1705 SGNAGRTLQQHNPMLIA-----QLQGVSPYNARQYQQNQRRGLNSPGAVGPGGNPAA------QA 1758
            .|....|....|.|.|:     ...|:|..|    |...:..:.|..:|...|.|:.      ..
Mouse  1378 FGQQANTSMYSNNMNISVSMATNTGGLSSMN----QMTGQMSMTSVTSVPTSGLPSMGPEQVNDP 1438

  Fly  1759 ALQRQNSFQGQ-GGGGATTPDGSGVGFGG-PQSPYGTNVNVFQQQQLQRLQRQG-------SVPQ 1814
            ||:..|.|..| .|......:|.....|| ||:.|          .|:.|...|       ||..
Mouse  1439 ALRGGNLFPNQLPGMDMIKQEGDASRTGGRPQTDY----------SLRELHTDGWSVHLRHSVRD 1493

  Fly  1815 ATQHLPGS 1822
            :...||.|
Mouse  1494 SATCLPVS 1501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 23/51 (45%)
PAS 377..442 CDD:214512 17/68 (25%)
PAS_11 591..711 CDD:291273 30/122 (25%)
Ncoa2XP_017174718.1 bHLH-PAS_NCoA2_SRC2 28..91 CDD:381520 28/66 (42%)
PAS 118..175 CDD:214512 15/68 (22%)
PAS_11 268..378 CDD:405306 30/121 (25%)
NCOA_u2 463..587 CDD:406952 42/179 (23%)
SRC-1 636..709 CDD:400955 17/75 (23%)
DUF4927 731..816 CDD:406644 14/84 (17%)
Nuc_rec_co-act 1076..1120 CDD:400942 9/45 (20%)
Med15 <1130..>1408 CDD:312941 76/378 (20%)
DUF1518 1284..1341 CDD:400033 17/72 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837739
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10684
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.930

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