DRSC/TRiP Functional Genomics Resources

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Protein Alignment tai and Ncoa1

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:XP_006515068.1 Gene:Ncoa1 / 17977 MGIID:1276523 Length:1447 Species:Mus musculus


Alignment Length:1813 Identity:364/1813 - (20%)
Similarity:597/1813 - (32%) Gaps:597/1813 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 NNEKRRREAENGYIEQLSEILTLNKRG-DMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTST 305
            :.||||||.||.|:|:|:|:|:.|... |..|.||||..||.:.|             |......
Mouse    30 STEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTV-------------DQIQLMK 81

  Fly   306 NNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPE-----PS 365
            ......:||:::                               ||:.::||:...:.|     |.
Mouse    82 RMEQEKSTTDDD-------------------------------VQKSDISSSSQGVIEKESLGPL 115

  Fly   366 LLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYS 430
            ||           |||:.:       ...||..|.|...::|:...:||.::||.:..:|..|:.
Mouse   116 LL-----------EALDGF-------FFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHV 162

  Fly   431 GDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGL 495
            ||||  |.:.|.:        ..|..|..|           |..                     
Mouse   163 GDHA--EFVKNLL--------PKSLVNGVP-----------WPQ--------------------- 185

  Fly   496 GGAGGAAAGKKRSISTKVRMLV---KDTRTATQTSSNCEEKPLRQSGHQDKYE--EVVLIAAP-- 553
                  .|.::.|.:...|||:   :|..|..|.:  |:           :||  :...::.|  
Mouse   186 ------EATRRNSHTFNCRMLIHPPEDPGTENQEA--CQ-----------RYEVMQCFTVSQPKS 231

  Fly   554 VKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQH 618
            :::|.:...|.|..|.|.....|....::..:.:|         |..|||:::|.::||.     
Mouse   232 IQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQ---------DTTGKIISIDTSSLRA----- 282

  Fly   619 LQTWVGRL-WQDLCHP----------HDLSTLKSHLRDIQDSASANSPGAGAGTSVVSRPFRLRL 672
                .||. |:||...          .:.|..:...:::....:|:||         |..|.|..
Mouse   283 ----AGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSP---------SYRFILND 334

  Fly   673 GAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTL------LNSENDMNSS----------NTGAGS 721
            |.. :..|.|.  :|...|:|....|||.:..:      |:.::|.||.          |.|. |
Mouse   335 GTM-LSAHTKC--KLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDSNSGMSIPRINPSVNPGI-S 395

  Fly   722 GGLGLGQLCAMAPS-PSLASSLLSSLSMDGLHGGTG-SGSSSSPAASGMLPTHLLGGLVGGGQ-- 782
            ...|:.:...:.|| .::.|:.::......|:..:. :.||::....|..|         |.|  
Mouse   396 PAHGVTRSSTLPPSNNNMVSARVNRQQSSDLNSSSSHTNSSNNQGNFGCSP---------GNQIV 451

  Fly   783 ------QGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASP 841
                  ||..|:.:...|:.   ::::.:.|||:...|....|..|:|..::.|....|:|..: 
Mouse   452 ANVALNQGQAGSQSSNPSLN---LNNSPMEGTGIALSQFMSPRRQANSGLATRARMSNNSFPPN- 512

  Fly   842 APAEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPR-----PPSGHG 901
            .|...|..|..:                    ||..:   |:|:....||::.:     |.:..|
Mouse   513 IPTLSSPVGITS--------------------GACNN---NNRSYSNIPVTSLQGMNEGPNNSVG 554

  Fly   902 FSPAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQNQQ-Q 965
            ||   ..||......|.:|.:.|....:.|.:                  |..|::....|:. |
Mouse   555 FS---AGSPVLRQMSSQNSPSRLSMQPAKAES------------------KDSKEIASILNEMIQ 598

  Fly   966 SNNNSSSSN---PLLGGGLPN----GVGGMLLSQQQQQ--QQTPPQQQQQQQQQESSERLRHLL- 1020
            |:|:.:|:|   ||..|.|.|    ..|....||...:  |......:||.:..:.....:.:| 
Mouse   599 SDNSDNSANEGKPLDSGLLHNNDRLSEGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLS 663

  Fly  1021 ---TKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSM 1082
               |.|.:.:...||.....     ..|..|:|                              .:
Mouse   664 CTGTSSSASSNPSGGTCPSS-----HSSLTERH------------------------------KI 693

  Fly  1083 LHKAGNSQNPMLLKLLNEKSEDDDG---------NGSGGGPGSM---------NNSRQSELMRQL 1129
            ||:.....:|..:..|:.:.|..|.         :|...|..|:         ..|:..:|:|.|
Mouse   694 LHRLLQEGSPSDITTLSVEPEKKDSVPASTAVSVSGQSQGSASIKLELDAAKKKESKDHQLLRYL 758

  Fly  1130 KNPDGGSHGMHRNSASGNMSTEDLKAML--KIQSDPSLNRKRSLNEPDDD--------------- 1177
            .:.|...     ..::.|:..:|:|..:  |.|.||.......:.:|..:               
Mouse   759 LDKDEKD-----LRSTPNLCLDDVKVKVEKKEQMDPCNTNPTPMTKPAPEEVKLESQSQFTADLD 818

  Fly  1178 ------PSAKRSEDKPSKLCTQNKMLAKLLQNPPKIPKAPNPEQPL------QVKTLPDITSSTV 1230
                  |:.:::...|| ||..::|...:.....|....|...||.      ::..||::....:
Mouse   819 QFDQLLPTLEKAAQLPS-LCETDRMDGAVTGVSIKAEVLPASLQPTTARAAPRLSRLPELELEAI 882

  Fly  1231 SSTLAAPGNLISAGSTGPKA-----AANRNRKQQQQQQQQQQQQQQQQVAGIPSQQQQQQPNDVY 1290
            .:....||    ||...|.|     ..|:|:                             |.|..
Mouse   883 DNQFGQPG----AGDQIPWANNTLTTINQNK-----------------------------PEDQC 914

  Fly  1291 LSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAIL-GEGDSELSKL-------- 1346
            :|.|..:.|..|              |::.......|......:.| |:.::||::|        
Mouse   915 ISSQLDELLCPP--------------TTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDK 965

  Fly  1347 ------LDSVMEYYP----------DDTPIV----TNAPSEASAINDIQKSLMLDVESAAFGNDL 1391
                  ||.:.|.:|          :|.|.:    .::||..:.:            |..|    
Mouse   966 LVQGGGLDVLSERFPPQQATPPLMMEDRPTLYSQPYSSPSPTAGL------------SGPF---- 1014

  Fly  1392 NQQLMMTQQQQHQQQQQQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQ----Q 1452
              |.|:.|:........|........:.....|.:|.|.:|||.|..|.:|.||..|.||    |
Mouse  1015 --QGMVRQKPSLGAMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQ 1077

  Fly  1453 NQQHIMQRLEAMRNQG---NQGFQR---PPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQ 1511
            |:|.|:.:..|....|   ..|.|:   |.|        |:||            |.|  .::|:
Mouse  1078 NRQAILNQFAANAPVGMNMRSGMQQQITPQP--------PLNA------------QML--AQRQR 1120

  Fly  1512 QLAAAQQKERLLQQQQKQQLL-----------------------VPENASE-------YWGNSNL 1546
            :|.:.|.::|.:.|||:..|:                       :|:.|.:       |..|...
Mouse  1121 ELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGTPRLPQGAPQQFPYPPNYGTNPGT 1185

  Fly  1547 QLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSLSRTNLPSDAQLSPNFAQTLMQQQ---LSP 1608
            ........|.:.|...|.|....|::|...|.|:...     ..|.:||...|.:.|..   |.|
Mouse  1186 PPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQ-----FGAGISPQMQQNVFQYPGPGLVP 1245

  Fly  1609 GRSAPYSPQPNQGYAPQFPQPGQRLSPQQQQQLSQQQQNNVQQ--QQLAYQQQQVGDGGRSNTPF 1671
            ...|.::|..:.| :...|.|   :.|.|...|.|....:..|  ...|:||..:|:....:...
Mouse  1246 QGEATFAPSLSPG-SSMVPMP---VPPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAV 1306

  Fly  1672 GSNSGMQSPGMQNSPQQWGSGGGGGGGPGGPLPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQ 1736
            .|......||:.|:.....|..|           |||  .:|..|||:               .|
Mouse  1307 QSQPAPAQPGVYNNMSITVSMAG-----------GNA--NIQNMNPMM---------------GQ 1343

  Fly  1737 NQRRGLNSPGAVGPGGNPAAQAALQRQNSFQGQGGGG---ATTPDGSGVGFGGPQSPYGTNVNVF 1798
            .|...|..||............||:....:..|....   .|..||:                  
Mouse  1344 MQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTDADGN------------------ 1390

  Fly  1799 QQQQLQRLQRQGSVPQATQHLPGSPRFGSSPGSSNNTDSSAAAGNQQQQQQQQQQQQQ 1856
              ||:|::|....| |.|.:|.|...:.:.||....  ....:|.|..|.||:...||
Mouse  1391 --QQVQQVQVFADV-QCTVNLVGGDPYLNQPGPLGT--QKPTSGPQTPQAQQKSLLQQ 1443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 22/44 (50%)
PAS 377..442 CDD:214512 19/64 (30%)
PAS_11 591..711 CDD:291273 29/136 (21%)
Ncoa1XP_006515068.1 bHLH-PAS_NCoA1_SRC1 27..87 CDD:381518 24/69 (35%)
PAS 120..213 CDD:238075 29/147 (20%)
PAS_11 260..370 CDD:405306 29/139 (21%)
NCOA_u2 469..591 CDD:406952 32/169 (19%)
SRC-1 636..712 CDD:400955 15/110 (14%)
DUF4927 747..824 CDD:406644 13/81 (16%)
Nuc_rec_co-act 930..975 CDD:400942 8/44 (18%)
Med15 980..>1366 CDD:312941 99/462 (21%)
DUF1518 1155..1211 CDD:400033 9/55 (16%)
DUF1518 1218..1274 CDD:400033 15/64 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837740
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10684
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.930

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