DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tai and Clock

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:NP_001276755.1 Gene:Clock / 12753 MGIID:99698 Length:855 Species:Mus musculus


Alignment Length:1231 Identity:223/1231 - (18%)
Similarity:371/1231 - (30%) Gaps:486/1231 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   237 QINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTSTKPDKAAILNQVV---RTYREICDKGQNR 298
            ::::..:||:||:..|..|::|..:|..|.|      |.||:.:|.:.:   |.::|        
Mouse    36 RVSRNKSEKKRRDQFNVLIKELGSMLPGNAR------KMDKSTVLQKSIDFLRKHKE-------- 86

  Fly   299 DISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPE 363
                           |...::::......||...|..                           |
Mouse    87 ---------------TTAQSDASEIRQDWKPTFLSNE---------------------------E 109

  Fly   364 PSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYL 428
            .:.|:         .|||:.:       .|.:..:|.|...::::..|:.:...:|..|.::.::
Mouse   110 FTQLM---------LEALDGF-------FLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFI 158

  Fly   429 YSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSSGAG 493
            ..|:|:::..|::|        :...:::..|               |.|.:.|..:.....   
Mouse   159 PEGEHSEVYKILST--------HLLESDSLTP---------------EYLKSKNQLEFCCHM--- 197

  Fly   494 GLGGAGGAAAGKKRSISTKVRMLVK-DTRTATQTSSNCEEKPLRQSGHQDKYEEVVLIAAPVKDD 557
                ..|....|:.|....||.:.. .:.|:..||::...:...|..|:..||:.|...|.|:..
Mouse   198 ----LRGTIDPKEPSTYEYVRFIGNFKSLTSVSTSTHNGFEGTIQRTHRPSYEDRVCFVATVRLA 258

  Fly   558 ADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLD----PTALREPFKQH 618
            .......:|.:                  ::|.|:.|.:..:..|.|.||    |.....||:. 
Mouse   259 TPQFIKEMCTV------------------EEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEV- 304

  Fly   619 LQTWVGRLWQDLCHPHDLSTL-KSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVK 682
                :|....|..|..||..| |.|...:|         .|.|.|...|    .|.....::.::
Mouse   305 ----LGTSGYDYYHVDDLENLAKCHEHLMQ---------YGKGKSCYYR----FLTKGQQWIWLQ 352

  Fly   683 ANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLS 747
            .:..:..:|.....:||:...|:: |..::.:.....    ||:.:        ||..       
Mouse   353 THYYITYHQWNSRPEFIVCTHTVV-SYAEVRAERRRE----LGIEE--------SLPE------- 397

  Fly   748 MDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQ 812
                   |.:..|                     |..|..|...|.|:                 
Mouse   398 -------TAADKS---------------------QDSGSDNRINTVSL----------------- 417

  Fly   813 QQQQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWT 877
                              ...:..|..||.|:..|                             .
Mouse   418 ------------------KEALERFDHSPTPSASS-----------------------------R 435

  Fly   878 DSRPNSRASVATPVSTP--------RPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAG 934
            .||.:|..:|:.|.|||        .||..|               |.:|...:    |..:|  
Mouse   436 SSRKSSHTAVSDPSSTPTKIPTDTSTPPRQH---------------LPAHEKMT----QRRSS-- 479

  Fly   935 GGNYGGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNSSSSNPLLGGGLPNG---------VGGMLL 990
                  |:..|.:|..|.|  .:.|....|.:|.           .:|.|         :|.|..
Mouse   480 ------FSSQSINSQSVGP--SLTQPAMSQAANL-----------PIPQGMSQFQFSAQLGAMQH 525

  Fly   991 SQQQQQQQTPPQQQQQQQQQESSERLRHLLTKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGF 1055
            .:.|.:|:|...:....:||   |.||.:..:.|.:.|                           
Mouse   526 LKDQLEQRTRMIEANIHRQQ---EELRKIQEQLQMVHG--------------------------- 560

  Fly  1056 KMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSEDDDGNGSGGGPGSMNNS 1120
                  .|:.||....:.|...|:..:  .:||| |...|..:|.:.:....|....|..|.   
Mouse   561 ------QGLQMFLQQSNPGLNFGSVQL--SSGNS-NIQQLTPVNMQGQVVPANQVQSGHIST--- 613

  Fly  1121 RQSELMRQLKNPDGGSHGMHRNSASGNMSTEDLKAMLKIQSDPSLNRKRSLNEPDDDPSAKRSED 1185
                             |.|........||...::...:.|..|  ::.||  |...||...:..
Mouse   614 -----------------GQHMIQQQTLQSTSTQQSQQSVMSGHS--QQTSL--PSQTPSTLTAPL 657

  Fly  1186 KPSKLCTQNKMLAKLLQNPPKIPKAPNPEQPLQVKTLPD----------------ITSSTVSSTL 1234
            ..:.:.:| .....::|.|..:|:  |..|...|.|...                :|:......:
Mouse   658 YNTMVISQ-PAAGSMVQIPSSMPQ--NSTQSATVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAV 719

  Fly  1235 AAP-----GNLISA---GSTGPKAAANRNRKQQQQQQQQQ--QQQQQQQVAGIPSQQQQ----QQ 1285
            ..|     |.:::|   .:|..:.|...:..|||||||||  |||||||.:   ||:||    ||
Mouse   720 MVPSTMLMGQVVTAYPTFATQQQQAQTLSVTQQQQQQQQQPPQQQQQQQQS---SQEQQLPSVQQ 781

  Fly  1286 PNDVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSV 1350
            |....|.|..||.||:.:|                              :.|...::|       
Mouse   782 PAQAQLGQPPQQFLQTSRL------------------------------LHGNPSTQL------- 809

  Fly  1351 MEYYPDDTPIVTNAPSEASAINDIQKSLMLDVESAAFGNDLNQQLM-MTQQQQHQQQQQQQ 1410
                                           :.||||  .|.|... .:..||||.|||||
Mouse   810 -------------------------------ILSAAF--PLQQSTFPPSHHQQHQPQQQQQ 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 14/51 (27%)
PAS 377..442 CDD:214512 12/64 (19%)
PAS_11 591..711 CDD:291273 28/124 (23%)
ClockNP_001276755.1 bHLH-PAS_CLOCK 29..89 CDD:381577 17/81 (21%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19414601 32..47 2/10 (20%)
PAS 109..>177 CDD:366402 15/91 (16%)
PAS_11 274..377 CDD:373151 27/121 (22%)
Interaction with NR3C1. /evidence=ECO:0000269|PubMed:19141540 371..854 141/758 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..411 6/61 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..497 25/134 (19%)
Interaction with SIRT1. /evidence=ECO:0000269|PubMed:18662547 450..570 35/195 (18%)
Implicated in the circadian rhythmicity 514..564 13/85 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..650 9/60 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 752..791 24/41 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..855 13/26 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.