Protein Alignment tai and Bmal1

DIOPT Version :10

• Sequence 1: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Sequence 2: NP_001398905.1
• Gene: Bmal1 / 11865
• MGIID: 1096381
• Length: 638
• Species: Mus musculus
• Alignment Length: 719
• Identity: 139/719 - (19%)
• Similarity: 240/719 - (33%)
• Gaps: 249/719 - (34%)

  Fly   236 SQINKCNNEKRRREAENGYIEQLSEIL-TLNKRGDMTSTKPDKAAILNQVVRTYREICDKGQNRD 299
            |||     |||||:..|.:|::|:.:: |.|    ..|.|.||..:|...|:..:.:  :|
Mouse    85 SQI-----EKRRRDKMNSFIDELASLVPTCN----AMSRKLDKLTVLRMAVQHMKTL--RG---- 134

  Fly   300 ISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPEP 364
                         .||..|.:|     .||...|.
Mouse   135 -------------ATNPYTEAN-----YKPTFLSD------------------------------ 151

  Fly   365 SLLLGQVPEISAYFEALEHYI--SGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMY 427
                          :.|:|.|  :..|::.:.....|.|...::::..::.|.:.:|..|.|:.|
Mouse   152 --------------DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDY 202

  Fly   428 LYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGS--SAGTSAGVWGDLEELNNGNASQGSNSS 490
            |:..|.||::..:             |::::.|...  .|.|...|..|:..
Mouse   203 LHPKDIAKVKEQL-------------SSSDTAPRERLIDAKTGLPVKTDITP------------- 241

  Fly   491 GAGGLGGAGGAAAGKKRSISTKVR-----MLVKDTRTATQTSSNCEEK--------PLRQSGHQD 542
                  |.....:|.:||...:::     :.|:|...|    |.|.:|        .:..:|:..
Mouse   242 ------GPSRLCSGARRSFFCRMKCNRPSVKVEDKDFA----STCSKKKADRKSFCTIHSTGYLK 296

  Fly   543 KYEEVVLIAAPVK---------DDADASSSVLCLITRPEDESPLEINIQQHVQQQP------IEQ 592
            .:       .|.|         |:...:.|.|..|.|          :..|:..||      ::.
Mouse   297 SW-------PPTKMGLDEDNEPDNEGCNLSCLVAIGR----------LHSHMVPQPANGEIRVKS 344

  Fly   593 MTF--KLDIHGKILTLD--PTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDI---QDSA 650
            |.:  :..|.||.:.:|  .||:.....|.|   :|....:..|..|:..|....|.:   ::..
Mouse   345 MEYVSRHAIDGKFVFVDQRATAILAYLPQEL---LGTSCYEYFHQDDIGHLAECHRQVLQTREKI 406

  Fly   651 SANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSS 715
            :.|           ...|:::.|:   ::.:::....|:|....|.::|:|..|::       .:
Mouse   407 TTN-----------CYKFKIKDGS---FITLRSRWFSFMNPWTKEVEYIVSTNTVV-------LA 450

  Fly   716 NTGAGSGGLGLGQLCAMAPSPSLASSLLSS-------------LSMDGLHGGT--GSGSSSSPAA 765
            |...| |.....||  .||..|:.|.|.|.             .::.|:.|||  |:|......|
Mouse   451 NVLEG-GDPTFPQL--TAPPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPGGTRAGAGKIGRMIA 512

  Fly   766 SGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSS----AIING-------TGLQQQQQQQQR 819
            ..::..|.:.   |......|.:....||...|..||    .|:||       |||...|.|:..
Mouse   513 EEIMEIHRIR---GSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSTGLLPGQAQETP 574

  Fly   820 SGASSSASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFE----------LDPSGGVG 874
            ....|.:||..             .|:...|.|..:.|..:.|.|.:          |:...|:|
Mouse   575 GYPYSDSSSIL-------------GENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLG 626

  Fly   875 AWTD 878
            ...|
Mouse   627 GPVD 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	bHLH_SF	239..291	CDD:469605	16/52 (31%)
		PAS	377..442	CDD:214512	15/66 (23%)
		PAS_11	590..711	CDD:464214	23/127 (18%)
Bmal1	NP_001398905.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:16980631	36..41
		bHLH-PAS_ARNTL_PASD3	74..137	CDD:381444	20/79 (25%)
		Nuclear export signal 1. /evidence=ECO:0000269|PubMed:16980631	149..159		3/53 (6%)
		PAS	156..215	CDD:214512	14/58 (24%)
		PAS_11	346..448	CDD:464214	22/118 (19%)
		Nuclear export signal 2. /evidence=ECO:0000269|PubMed:16980631	368..376		2/10 (20%)
		Interaction with CIART	520..600		21/95 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..607		23/96 (24%)