DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tai and NCOA2

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:XP_016868450.1 Gene:NCOA2 / 10499 HGNCID:7669 Length:1533 Species:Homo sapiens


Alignment Length:1905 Identity:395/1905 - (20%)
Similarity:615/1905 - (32%) Gaps:665/1905 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 ISANSANSATSGR-KIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRG-DMT 271
            :|....|::...| :.|::.:....|..|.  |.|.|||.||.||.|||:|:|::..|... |..
Human     1 MSGMGENTSDPSRAETRKRKECPDQLGPSP--KRNTEKRNREQENKYIEELAELIFANFNDIDNF 63

  Fly   272 STKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRC 336
            :.||||.|||.:.|:..|:|  |.|.:..::                                  
Human    64 NFKPDKCAILKETVKQIRQI--KEQEKAAAA---------------------------------- 92

  Fly   337 SRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGII 401
                    :|..||:.:||||...:.:.. .||.:     ..|||:.:       ...||..|.:
Human    93 --------NIDEVQKSDVSSTGQGVIDKD-ALGPM-----MLEALDGF-------FFVVNLEGNV 136

  Fly   402 ESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKL------EPIINTMYNNPNGGNSNSANNSGP 460
            ...::|:...:.|.::||.::.:|..|:.|||.:.      :.|:|                   
Human   137 VFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVN------------------- 182

  Fly   461 GGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQ 525
            |||.:|...                                   ::.|.:...|||||....:. 
Human   183 GGSWSGEPP-----------------------------------RRNSHTFNCRMLVKPLPDSE- 211

  Fly   526 TSSNCEEKPLRQSGHQDKYEEVVLIAA----PVKDDA-DASSSVLCLITR-PEDESPLEINIQQH 584
                 ||....|..|| |||.:...|.    .:|::. |..|.::|:..| |..|.|:       
Human   212 -----EEGHDNQEAHQ-KYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPV------- 263

  Fly   585 VQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHD---LSTLKSHLRDI 646
              ....|..|.:.|:.|||.:||.:.:|...|...:..|.|..|.....|:   :|..|.|..::
Human   264 --LPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEV 326

  Fly   647 QDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSEND 711
            .....|           .|:.:|..| :....|..:..|:|..:||..|...::|:..|...:| 
Human   327 LRQGLA-----------FSQIYRFSL-SDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN- 378

  Fly   712 MNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGG 776
                             :|.|.|.               |.|.| .|...:|.:|.. |.|  ..
Human   379 -----------------VCVMNPD---------------LTGQT-MGKPLNPISSNS-PAH--QA 407

  Fly   777 LVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASP 841
            |..|..   |.:.|.::::..|      |||. .:|......|.|.|...:.     |:...|: 
Human   408 LCSGNP---GQDMTLSSNINFP------INGP-KEQMGMPMGRFGGSGGMNH-----VSGMQAT- 456

  Fly   842 APAEHSFYGSDTFEFDIAAHSSSFEL---DPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFS 903
                             ....|::.|   .||       .|.|.......|.:.:||    |..|
Human   457 -----------------TPQGSNYALKMNSPS-------QSSPGMNPGQPTSMLSPR----HRMS 493

  Fly   904 PAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDV----------------- 951
            |.|..||..|....| .|.||.||....|:.|      |.||:.:|.:                 
Human   494 PGVAGSPRIPPSQFS-PAGSLHSPVGVCSSTG------NSHSYTNSSLNALQALSEGHGVSLGSS 551

  Fly   952 --KPEKDVQQQQNQQQSNN-------NSSSSNPLLG--GGLPNGVGGMLLS--QQQQQQQT---- 999
              .|:..:...||...:.|       .|..|....|  |....|..|...|  ...:|::|    
Human   552 LASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPN 616

  Fly  1000 -PPQQQQQQQQQES--------SERLRHLLTKSQSM-----AGGLGGLGDDEKYFKPEGSEEEKH 1050
             ||....::...:|        ::.|:.|.|||..|     |..|              |:..|.
Human   617 LPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSL--------------SDTNKD 667

  Fly  1051 ASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHK-AGNSQNPM-LLKLLNEKS-EDDDGNGSGG 1112
            ::|.....|...|..:          .....:||: ..:|.:|: |.||..|.: :|.....|..
Human   668 STGSLPGSGSTHGTSL----------KEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSST 722

  Fly  1113 GPGS---------MNNSRQSELMRQLKNPDGGSHGMHRNSASGNMSTEDL--------KAMLKIQ 1160
            .|||         ....:::.|:|.|.:.|               .|:|:        ...|..:
Human   723 APGSEVTIKQEPVSPKKKENALLRYLLDKD---------------DTKDIGLPEITPKLERLDSK 772

  Fly  1161 SDPSLN--------RKRSLN-EPDDDPSAKRS-------------------EDKP-------SKL 1190
            :||:.|        .|..:: ||.|.|.::..                   :.:|       .|.
Human   773 TDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQ 837

  Fly  1191 CTQNKMLAKLLQNPPKIPKA-------------------------PNPEQPLQVKTL-------- 1222
            ...|.::....:|.|..|..                         ||...||.: ||        
Human   838 AIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDI-TLQSPTGAGP 901

  Fly  1223 -PDITSSTVSSTLAAPGNLISAG-----------STG-----------------PKAAANR---- 1254
             |.|.:|:..|.:..||.:.:.|           |||                 |:::|.|    
Human   902 FPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCA 966

  Fly  1255 ------NRKQQ--------------QQQQQQQQQQQQQQVAGI-PSQ-----------QQQQQPN 1287
                  ||..|              ...|..|:|..|.||..| ||:           |||..||
Human   967 ATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPN 1031

  Fly  1288 DVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILG---------EGDSEL 1343
            ......:....:.....|.|::|...::...:......:.:.:...|:|.         :|..|:
Human  1032 QTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEI 1096

  Fly  1344 SKLLDSVMEYYPDDTPIVTNAPSEASAINDIQ-----KSLMLDVESAAFGNDLNQQLMMTQQQQH 1403
            .:.|.            :....|::.|::..|     .::||:.::..|......|..|.|....
Human  1097 DRALG------------IPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS 1149

  Fly  1404 QQQQ-------QQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQQNQQHIMQRL 1461
            ..|.       |:.....|:: |.:...|...|.|  ..|..|.: |.||:.|.|||:|.:|.::
Human  1150 PMQDPNFHTMGQRPSYATLRM-QPRPGLRPTGLVQ--NQPNQLRL-QLQHRLQAQQNRQPLMNQI 1210

  Fly  1462 EAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQQKE----RL 1522
            ..:.|                    :|....||   :|.|..:     ..|:.|.:|:|    .|
Human  1211 SNVSN--------------------VNLTLRPG---VPTQAPI-----NAQMLAQRQREILNQHL 1247

  Fly  1523 LQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSLSRTNL 1587
            .|:|..||..|.:.                  :.::.|.  |||...|::..:|.| .::|...:
Human  1248 RQRQMHQQQQVQQR------------------TLMMRGQ--GLNMTPSMVAPSGMP-ATMSNPRI 1291

  Fly  1588 P-SDAQ---LSPNFAQTLMQQQLSPGRSAPYSPQPNQGYAPQFPQPGQRLSPQQQQQLSQQQQNN 1648
            | ::||   ..||:...|.            ||       |.|..|...:||....||......:
Human  1292 PQANAQQFPFPPNYGTGLR------------SP-------PPFTSPFSPVSPSVGSQLLSHSSLH 1337

  Fly  1649 VQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNS---------PQQWGSGGGGGGGPGGPLP 1704
            ..|..|| .|..:|:.|      |....::||.:|:|         .||...|..|...|..||.
Human  1338 GSQMNLA-NQGMIGNLG------GQLGPVRSPQVQHSTFQALSSGISQQPDPGFTGATTPQSPLM 1395

  Fly  1705 SGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGLNSPGAVGPGGNPAAQAALQRQNSFQGQ 1769
            |.....|   .:||:               ||:|             .|||.||........||.
Human  1396 SPRMAHT---QSPMM---------------QQSQ-------------ANPAYQAPSDINGWAQGN 1429

  Fly  1770 GGGGATTPDGSGVGFG--GPQSPYGTNVNV--------FQQQQLQRLQRQGSVPQATQHLPGSPR 1824
            .||.:.....|...||  ...|.|..|:|:        .....:.::..|.|:...|    ..|.
Human  1430 MGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVT----SVPT 1490

  Fly  1825 FG-SSPGSSNNTDSSAAAGN 1843
            .| ||.|.....|.:...||
Human  1491 SGLSSMGPEQVNDPALRGGN 1510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 24/51 (47%)
PAS 377..442 CDD:214512 16/70 (23%)
PAS_11 591..711 CDD:291273 29/122 (24%)
NCOA2XP_016868450.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147657
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 116 1.000 Inparanoid score I4822
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10684
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.980

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