DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tai and ncoa2

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:NP_001135631.1 Gene:ncoa2 / 100216190 XenbaseID:XB-GENE-482311 Length:1440 Species:Xenopus tropicalis


Alignment Length:1990 Identity:413/1990 - (20%)
Similarity:618/1990 - (31%) Gaps:756/1990 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 ISANSANSATSGRKIRRKTDSKVNLPQSQIN---KCNNEKRRREAENGYIEQLSEILTLNKRG-D 269
            :|....|.:...|...||....::    |:.   |.:.|||.||.||.|||:|:|::..|... |
 Frog     1 MSGMGENPSDPSRAEPRKRKESID----QLGPSPKRSTEKRNREQENKYIEELAELIFANFNDID 61

  Fly   270 MTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATST 334
            ..:.||||.|||.:.|:..|:|              ..:..|...|.:                 
 Frog    62 NLNFKPDKCAILKETVKQIRQI--------------KEHEKTAAANED----------------- 95

  Fly   335 RCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANG 399
                         .||:.:||||...:.:.. .||.:     ..|||:.:       ...||..|
 Frog    96 -------------EVQKADVSSTGQSVIDKD-ALGPM-----MLEALDGF-------FFVVNREG 134

  Fly   400 IIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSS 464
            .:...::|:...:.|.::||.:..:|..|:.|||:  |.|.|.:        ..|..|.||    
 Frog   135 NVVFVSENVTQYLRYNQEELMNTSVYSILHVGDHS--EFIKNLL--------PKSIVNGGP---- 185

  Fly   465 AGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSN 529
                                                    ::.|.:...|||||       ....
 Frog   186 ----------------------------------------RRNSHTFNCRMLVK-------PMME 203

  Fly   530 CEEKPLRQSGH-----QDKYEEVVLIAA----PVKDDA-DASSSVLCLITR-PEDESPLEINIQQ 583
            |||:     ||     ..|||.:...|.    .:|::. |..|.::|:..| |..|.|:      
 Frog   204 CEEE-----GHDGQETHQKYETMQCFAVSQPKSIKEEGEDFQSCLICVARRVPMKERPV------ 257

  Fly   584 HVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDL---C-------HPHDLST 638
               ..|.|..|.:.|:.|||.:||.|.:|...:..        |:||   |       |..::|.
 Frog   258 ---PPPSESFTTRQDLQGKITSLDTTNMRALMRPG--------WEDLVRRCIQRFHSQHDGEISY 311

  Fly   639 LKSHLRDIQDSASANSP----GAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFI 699
            .|.|.:::.....|.||    ....||:|::              |.|  |:|..:||..|...:
 Frog   312 SKRHHQEVLRQGHATSPFYRFALSDGTTVLA--------------HTK--SKLMRSQTTNEPQLV 360

  Fly   700 MSVQTLLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPA 764
            :|:..|...:|                  :|.:  :..||              |...|.:.:|.
 Frog   361 LSLHVLQREQN------------------MCGL--NQDLA--------------GQAMGKTLNPV 391

  Fly   765 ASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSS 829
            .|.. |.|         |...|||..|.|::... |:.||   ||   .::|...:......|..
 Frog   392 QSSS-PAH---------QAMYGGNPGQDTTISSN-MNYAI---TG---PKEQMGMAAGRFVGSGG 439

  Fly   830 ANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFEL---DPSGGVGAWTDSRPNSRASVATPV 891
            .|.:.:....:|                   ..:::.|   .||.|.......:|||..|     
 Frog   440 MNHISSLQATTP-------------------QGNNYALKINSPSQGSPGMGQGQPNSMLS----- 480

  Fly   892 STPRPPSGHGFSPAVCASP-ATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEK 955
              ||    |..||.|..|| ..|.|.|  .|.||.||.|..|:.|      |.||:.:|.:...:
 Frog   481 --PR----HRVSPGVAGSPRIAPSQFS--PAGSLHSPVSVCSSTG------NSHSYTNSSLNALQ 531

  Fly   956 DVQQQQNQQQSNNNSSSSNPLLGGGLPNG---------VGGMLLSQQQQQQQTPPQQQQQQQQQE 1011
            .:.:                  |.|:|..         ||.:   |.......|||         
 Frog   532 ALSE------------------GHGVPLAPPLSSPDLKVGNV---QHSPVNMNPPQ--------- 566

  Fly  1012 SSERLRHLLTKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGFKMGGQP---GGMGMFG----- 1068
                ||.:                        ||.:.|.:.|.:  |.||   .|.|..|     
 Frog   567 ----LRKM------------------------GSIDSKESFGLY--GEQPESAAGQGESGCHSNE 601

  Fly  1069 ------PMGSMG-RGVGNSSMLHKAGNSQNPMLLKLLNEKSEDDDGNGSGGGPGSMNNSRQSELM 1126
                  .:.|:| :..|.|.:|...|..:   |||||..||:..:       |..:.::...:: 
 Frog   602 QKDCSENLSSVGDQTEGQSRLLDSKGQQK---LLKLLTTKSDQME-------PSPLPSNTLGDM- 655

  Fly  1127 RQLKNPDGGSHGMHRNSASGNMSTEDLKAMLKIQSDPSLNRKRSLNEPDDDPSAKRSEDKPSKLC 1191
                |.|..|     |.||.:||.......||                                 
 Frog   656 ----NKDSLS-----NFASNSMSASAHGTSLK--------------------------------- 678

  Fly  1192 TQNKMLAKLLQNPPKIPKAPNPEQPLQVKTLPDITSSTVSSTLAAPGNLISAGSTGPKAAANRNR 1256
            .::|:|.:|||         :...|:.   |..:|:......|:...|     ||||.:.....:
 Frog   679 EKHKILHRLLQ---------DSSSPVD---LAKLTAEATGKELSQESN-----STGPGSEVTIKQ 726

  Fly  1257 KQQQQQQQQ--------QQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLAFQHQQLAT 1313
            :....::::        .:...:..||.|                       :|:|.....::..
 Frog   727 EPVSPKKKEHALLRYLLDKDDTKDNVADI-----------------------TPKLERPDVKVEP 768

  Fly  1314 TATTSITTAASTSAAAAAAAAILGEGD---------SELSKLLDSVM-----EYYPDDTPIVTNA 1364
            |:...:     .|..|.......|..|         ..|.::||.:.     :.:||.....:|:
 Frog   769 TSCPKL-----LSVKAEKEEPSFGHSDQLMPPGSDLDNLDEILDDLQNSQLSQLFPDARHDGSNS 828

  Fly  1365 PSEASAINDIQKSLMLDVESAAFGNDLNQQLMMTQQQQHQQQQQQQQLLALQLAQQQQQQRQQHL 1429
            ..:.:.:||:.:          ...|.:..|.....:|...:.||....:.|||.|..:...|.|
 Frog   829 ADKQAIMNDLMQ----------LAGDNSTGLPAGAHKQRMIRIQQNNGFSSQLAAQLGRLPNQSL 883

  Fly  1430 QQPPAYPGMLNMQQQ----------QHQQQQQQNQQHIMQRLEAMRNQGNQGFQRP--------- 1475
                  |..:|:|.|          ........:|..:|.....|.:|||.....|         
 Frog   884 ------PLDINLQSQVSAGSFPPMRNSAPYTTVSQSVVMNNQAMMGSQGNVSNSSPGIIGVNGPR 942

  Fly  1476 PPMYPARGRGPMNAV---------------------------ATPGGVVLPAQQQLRNIRQQQQL 1513
            |.:.|.......:||                           ..|||.|.|     |.:.|...:
 Frog   943 PALKPGDWGSQASAVRPACPTPSTAINRPIQDLTRSPTASIPMRPGGQVCP-----RQVLQSPVI 1002

  Fly  1514 -AAAQQKERLLQQQQKQQLLVPENASEYW------------GNSNLQ--------LIIKLIVSY- 1556
             ..:.:.:..:...|..|...|.|.:..|            .|.|.|        ||.:.|.|. 
 Frog  1003 NMGSSELDMNIGGPQYTQQQAPPNQTAPWPDSILPIDQPSFNNQNRQPFGSPADDLICQPIASQS 1067

  Fly  1557 ------ILAGMNAGLNNIGSLL---NTTGAPNVSLSRTNLPSDAQLSPNFAQTLMQQQLSPGRSA 1612
                  :|..:...|.|...|.   ...|.|.:......:..::.:||.  ..||.:|..|..:.
 Frog  1068 PTDDGNLLDQLYMALRNFDGLEEIDRALGIPEMVSQGQAVEQESFVSPE--SNLMMEQKPPLYNH 1130

  Fly  1613 PYSPQPNQGYAPQFPQPGQRLSPQQQQQLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGM 1677
            .|:   |||                     |..||                   |.||      |
 Frog  1131 AYA---NQG---------------------QMAQN-------------------SYTP------M 1146

  Fly  1678 QSPGMQNSPQQWGSGGGGGGGPGGPLPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGL 1742
            |.||.               .|.|..||  .|....|:.|       |:.|....|.|.||.|  
 Frog  1147 QDPGF---------------NPMGQRPS--YGILRMQNRP-------GLRPTGMVQNQPNQLR-- 1185

  Fly  1743 NSPGAVGPGGNPAAQAALQRQNSFQGQGGGGATTPDGS----------GV-GFGGPQSPYGTNVN 1796
                             ||.|:..|.|.......|..:          || |....|.|  .|..
 Frog  1186 -----------------LQLQHRLQAQNRQPIMNPINNVSNMNLAMRPGVPGQLREQGP--INAQ 1231

  Fly  1797 VFQQQQLQRLQRQGSVPQATQHLPGSPRFGSSPGSSNNTDSSAAAGNQQQQQQQQQQQQQQHQQQ 1861
            :..|:|.:.|         :|||                      ..:|.|||||||||||.|.|
 Frog  1232 MLAQRQRELL---------SQHL----------------------RQKQLQQQQQQQQQQQQQVQ 1265

  Fly  1862 QHQQLM---NGLSMSPHPHPHPAMMGVGGMGSGGGNGIIGLGGGGGNYGATL-----GGYGQSQQ 1918
            ||:.:|   .||:|.|:      |:|.||:.:...:..|..|.       |.     ..||.|||
 Frog  1266 QHRAMMMRGQGLAMPPN------MVGSGGIPASINSPRIPQGN-------TQQFPFPPNYGMSQQ 1317

  Fly  1919 AN-DFYGRAQTAGGGGSVAGGNANSEFVKQELRAVVSVRAQQAAAAATGGAGVGGGVAQRGQTPQ 1982
            :: .|.|.........|...|:..|..::|.       :|..|..:...|...|........:.|
 Frog  1318 SDPGFTGATTPQSPIMSPRMGHIQSPMMQQS-------QASPAYQSELNGWAQGNPAGNSMFSQQ 1375

  Fly  1983 SPLQQGSVIGGGGGIVGGVNSTNTMGNVTPTGSGNVSNSM 2022
            ||...|...|     ....||.|...:|:...:||..|||
 Frog  1376 SPPHFGQQSG-----TSMYNSNNMNISVSMAANGNGMNSM 1410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 23/54 (43%)
PAS 377..442 CDD:214512 17/64 (27%)
PAS_11 591..711 CDD:291273 33/133 (25%)
ncoa2NP_001135631.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 10/42 (24%)
bHLH-PAS_NCoA2_SRC2 28..91 CDD:381520 26/76 (34%)
PAS 118..175 CDD:214512 17/70 (24%)
PAS_11 262..371 CDD:373151 33/132 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..409 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 453..521 28/86 (33%)
NCOA_u2 456..580 CDD:374708 45/200 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..571 9/71 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 583..656 20/87 (23%)
SRC-1 626..703 CDD:370145 27/141 (19%)
LXXLL motif 1. /evidence=ECO:0000255 631..635 3/3 (100%)
LXXLL motif 2. /evidence=ECO:0000255 684..688 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..731 6/31 (19%)
DUF4927 725..812 CDD:374467 13/114 (11%)
LXXLL motif 3. /evidence=ECO:0000255 739..743 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 948..970 2/21 (10%)
PRK10263 <950..>1242 CDD:236669 76/401 (19%)
Nuc_rec_co-act 1066..1111 CDD:312376 6/44 (14%)
LLXXLXXXL motif. /evidence=ECO:0000255 1074..1082 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1287..1306 5/25 (20%)
DUF1518 1288..1344 CDD:369380 14/62 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 130 1.000 Inparanoid score I4510
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10684
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.150

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