Protein Alignment ATXN1L and Atx-1

DIOPT Version :10

• Sequence 1: NP_001131147.1
• Gene: ATXN1L / 342371
• HGNCID: 33279
• Length: 689
• Species: Homo sapiens
• Sequence 2: NP_572356.1
• Gene: Atx-1 / 31624
• FlyBaseID: FBgn0029907
• Length: 230
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 77/219 - (35%)
• Similarity: 111/219 - (50%)
• Gaps: 35/219 - (15%)

Human   455 PTPPPITSSHLPSH---------FMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTV 510
            |:.||.:..|..|:         |.:|:.|:||:|.::||||::|:||::||..|...::..:||
  Fly    21 PSLPPPSQQHWSSNGFSDDSASCFRRGSYIELASGAMRRVEDIRTEDFIQSALRSQLFELREATV 85

Human   511 VDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGD 575
            |.|..|..|..|.|.|......:|:.::|.|.||.|||||||:||.|..:.||:.|.|.:|||||
  Fly    86 VRIDWSGCPSLVTLTFSYDTHHAKMDLQVQPGHPMFVYGQGWASCDPQLSLQLYELKCQQLQVGD 150

Human   576 VCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGEGSRVVEPSQP 640
            :|:     ||..|....|.|  |.|..||...|..::..|.|:        |...||       |
  Fly   151 ICL-----SLVPNEQPAAPC--PPQPAPPPPCPPPSLPPSMEM--------PVPMGS-------P 193

Human   641 ESGAQACWPAPSFQR-YSMQGEEA 663
            .:|:....|   |:. |.|..:.|
  Fly   194 PTGSYGFLP---FKHPYEMYAQMA 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN1L	NP_001131147.1	ATXN-1_C	1..>253	CDD:463627
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		Interaction with NCOR2 and ATXN1. /evidence=ECO:0000269|PubMed:16121196	20..197
		Self-association	20..197
		PHA03247	<86..432	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..223
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..297
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..405
		AXH	469..582	CDD:462505	50/112 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	617..647		6/29 (21%)
Atx-1	NP_572356.1	AXH	43..158	CDD:197779	52/119 (44%)