DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and IL1RL1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_057316.3	Gene:	IL1RL1 / 9173	HGNCID:	5998	Length:	556	Species:	Homo sapiens

Alignment Length:	469	Identity:	99/469 - (21%)
Similarity:	166/469 - (35%)	Gaps:	135/469 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 WECNCKA------KAFLSFLRRHEPMEYETVLRRVEITDDKCPEDC--ICCVDTSNSDSLAYVVD 773
            |..||:|      :|..|||                :.|:...||.  ..|....|.:...|.|
Human   147 WFKNCQALQGSRYRAHKSFL----------------VIDNVMTEDAGDYTCKFIHNENGANYSV- 194

  Fly   774 CSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEY 838
                           |..::..|.:......:|....|..:.:....:..|
Human   195 ---------------TATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKN-------------- 230

  Fly   839 LDISNNNFSALDDRVRGFLQK---RMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASA 900
               :|...||...:...||..   ::|.:  :::.||.|   |.:        :|:.:|.:.::.
Human   231 ---ANLTCSACFGKGTQFLAAVLWQLNGT--KITDFGEP---RIQ--------QEEGQNQSFSNG 279

  Fly   901 IQCIDTGRSLIEVEETDICPSVLIYYTSLAVSL----------------------LIIA------ 937
            :.|:|....:.:|:|.|:    |:.|..||::|                      .|||
Human   280 LACLDMVLRIADVKEEDL----LLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFL 340

  Fly   938 LSINVFICFRQPIMIWFYEHEICLSLAARRELDED-KKYDAFLSF--THKDE----DLIEEFV-- 993
            :.|||.:...:  |.|.....:...:|...:...| |.|||::.:  .:|..    ..:|.||
Human   341 MLINVLVIILK--MFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQ 403

  Fly   994 ---DRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALH 1055
               |.||| :..:.||.|.||.|.||.:...:..:::.|||.|.::|.....:.....|..:|||
Human   404 ILPDVLEN-KCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALH 467

  Fly  1056 ATSRDRCKRLIVVLYPDVEHFDDLDSE-----LRAYM-VLNTYLDRN---------NPNFWNKLM 1105
            ........::|::....:...|.|.:|     |:..| |..|...|.         |..||..:.
Human   468 CALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVR 532

  Fly  1106 YSMPHASHLKRSRS 1119
            |.||..|.:.|..|
Human   533 YQMPVPSKIPRKAS 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378	1/1 (100%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	1/18 (6%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587	42/161 (26%)
IL1RL1	NP_057316.3	Ig	16..104	CDD:299845
		IG_like	21..104	CDD:214653
		Ig2_IL1R_like	118..204	CDD:143234	17/88 (19%)
		IG_like	120..197	CDD:214653	16/81 (20%)
		Flexible linker	198..211		1/12 (8%)
		TIR	380..535	CDD:279864	38/155 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910