DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and IL18R1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_003846.1	Gene:	IL18R1 / 8809	HGNCID:	5988	Length:	541	Species:	Homo sapiens

Alignment Length:	597	Identity:	126/597 - (21%)
Similarity:	227/597 - (38%)	Gaps:	149/597 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 INCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELP--- 672
            :|||.|.|.::            :.:..:.....|:...:.|......:..|.|.:|..|:.
Human     1 MNCRELPLTLW------------VLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTT 53

  Fly   673 ------------LHLLPENITYLDVRNNLLKY----LDDGVIAFLEYRENITKIELSGNPWECN- 720
                        :.|.|.:.:.:.:.:.:|::    |:|....|.:.:....|       |:.|
Human    54 KSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQK-------WKLNV 111

  Fly   721 CKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQL 785
            .:......|..|....:...|.:..:||.:......:.     ||.||  ..:|. |.|.|..:.
Human   112 IRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLV-----NSTSL--YKNCK-KLLLENNKN 168

  Fly   786 PTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHN-RLSDIDQLPDKLEYLDISNNNFSAL 849
            ||              :||.......||.|...| |.|| :|.:|.:           ..|.:.:
Human   169 PT--------------IKKNAEFEDQGYYSCVHF-LHHNGKLFNITK-----------TFNITIV 207

  Fly   850 DDR---VRGFLQKRMNSSQLQLSLFGNPWTCRC-------------------------EDKDFLV 886
            :||   |...|..::|...::|   |......|                         |:|:..:
Human   208 EDRSNIVPVLLGPKLNHVAVEL---GKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRI 269

  Fly   887 FVKE---------QAKNIANAS---AIQC--IDTG----RSLIEVEETDIC--PSVLIYYTSLAV 931
            ...|         :.:||..::   ...|  ..||    :|.|.|.:.|:.  |..:.....:..
Human   270 MTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIA 334

  Fly   932 SLLIIALSINVFIC--FRQPIMIWFYEHEICLSLAARRE-LDEDKKYDAFLSF-------THKDE 986
            .|:::|:...|.:|  :|..::: ||.|     |..|.| |.:.|.||||:|:       ..::.
Human   335 VLILVAVVCLVTVCVIYRVDLVL-FYRH-----LTRRDETLTDGKTYDAFVSYLKECRPENGEEH 393

  Fly   987 DLIEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFR 1051
            ....|.:.|:......::||.:.||.:.|.::.|.|:..::.|||:||:::|::: |...|.|..
Human   394 TFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYM-SNEVRYELE 457

  Fly  1052 LALHATSRDRCKRLIVVLYPDVEHFDDLDSE---LRAYMVLNTYLDRN---NPNFWNKLMYSMPH 1110
            ..||....:|..::|::.:..|..|..|...   |:::.||....|::   |..||..|:|.||
Human   458 SGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMP- 521

  Fly  1111 ASHLKRSRSDAE 1122
            |..:|..|.:.|
Human   522 AKTVKPGRDEPE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	2/24 (8%)
		leucine-rich repeat	658..679	CDD:275378	6/35 (17%)
		leucine-rich repeat	680..706	CDD:275378	4/29 (14%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	6/19 (32%)
		leucine-rich repeat	793..815	CDD:275378	4/21 (19%)
		leucine-rich repeat	816..835	CDD:275378	6/19 (32%)
		leucine-rich repeat	836..859	CDD:275378	5/25 (20%)
		TIR	974..1110	CDD:214587	40/148 (27%)
IL18R1	NP_003846.1	Ig	28..100	CDD:325142	11/71 (15%)
		Ig	129..208	CDD:325142	25/112 (22%)
		PHA02785	<171..312	CDD:333475	29/155 (19%)
		TIR	378..520	CDD:307630	36/142 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910