DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and IL1RL2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_011510393.1	Gene:	IL1RL2 / 8808	HGNCID:	5999	Length:	622	Species:	Homo sapiens

Alignment Length:	590	Identity:	103/590 - (17%)
Similarity:	221/590 - (37%)	Gaps:	155/590 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 LNSPCPYRCSCCFEWHT-GEFLIN-CRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKL------TN 646
            |::..|:..:|.|...| ||..:. .:|.|     ::|.|...::.::.|...|..|      :.
Human    60 LSASQPFAFNCTFPPITSGEVSVTWYKNSS-----KIPVSKIIQSRIHQDETWILFLPMEWGDSG 119

  Fly   647 TESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYL-----DDGVIAFLEYREN 706
            ....|:.|..|.|::|::..:..:   |....:|..|...::..|.:     ||.:...|.:.::
Human   120 VYQCVIKGRDSCHRIHVNLTVFEK---HWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKS 181

  Fly   707 ITKIELSGNPW--ECN-CKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSL 768
            ..   |....|  :|| .|.:.|             |||....:..:...||       ..:.:.
Human   182 CV---LGPIKWYKDCNEIKGERF-------------TVLETRLLVSNVSAED-------RGNYAC 223

  Fly   769 AYVVDCSGKEL----------------SEIPQLPTPTYGQ------TTLVFERNSLKKWPSSLLP 811
            ..::..|||:.                ..:|::..|....      |||:.:.|......::.|
Human   224 QAILTHSGKQYEVLNGITVSIKRAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNL- 287

  Fly   812 GYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRM---NSSQLQLSL--F 871
                  |.:..:|.|.|        :|.|.|......::..| .|.:..:   |.:.|::.:  :
Human   288 ------RCWRVNNTLVD--------DYYDESKRIREGVETHV-SFREHNLYTVNITFLEVKMEDY 337

  Fly   872 GNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLII 936
            |.|:.|...                       :.|...::::.    .|....|.....::|:.:
Human   338 GLPFMCHAG-----------------------VSTAYIILQLP----APDFRAYLIGGLIALVAV 375

  Fly   937 ALS-INVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSF--THKDE----------DL 988
            |:| :.::..|:..|::|:..     :..:...:.:.|.|||::.:  .||:.          ::
Human   376 AVSVVYIYNIFKIDIVLWYRS-----AFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNI 435

  Fly   989 IEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRL----E 1049
            :.|.::|    :..::|..:.||...|:::.:.|:::||..||:|:::....|  .:|.|    |
Human   436 LPEVLER----QCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESL--GFGLLKNLSE 494

  Fly  1050 FRLALH-ATSRDRCKRLIV---------VLYPDVEHFDDLDSELRAYMVLNTYLDRNNPNFWNKL 1104
            .::|:: |..:|..|.:::         |:...:::.......:|.:.............||..:
Human   495 EQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTV 559

  Fly  1105 MYSMP 1109
            .|.||
Human   560 RYHMP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	5/30 (17%)
		leucine-rich repeat	658..679	CDD:275378	3/20 (15%)
		leucine-rich repeat	680..706	CDD:275378	6/30 (20%)
		leucine-rich repeat	707..719	CDD:275378	2/13 (15%)
		leucine-rich repeat	771..791	CDD:275380	5/35 (14%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	4/18 (22%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587	32/162 (20%)
IL1RL2	XP_011510393.1	Ig	54..140	CDD:299845	19/84 (23%)
		Ig2_IL1R_like	158..245	CDD:143234	18/109 (17%)
		IG_like	171..229	CDD:214653	12/80 (15%)
		TIR	413..563	CDD:279864	27/155 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910