DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr9

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_112455.2	Gene:	Tlr9 / 81897	MGIID:	1932389	Length:	1032	Species:	Mus musculus

Alignment Length:	1111	Identity:	228/1111 - (20%)
Similarity:	381/1111 - (34%)	Gaps:	387/1111 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 LTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVD-----LKSFEKFT----------- 333
            |..|:.|:...|..:.|:.   .||.:.|. |.:|...:||     |||..:|:
Mouse     8 LHPLSLLVQAAVLAETLAL---GTLPAFLP-CELKPHGLVDCNWLFLKSVPRFSAAASCSNITRL 68

  Fly   334 -----------NLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNC-------SY 380
                       |.:.:.:|..:...         .|.:|..| |::    ||..:|       ::
Mouse    69 SLISNRIHHLHNSDFVHLSNLRQLN---------LKWNCPPT-GLS----PLHFSCHMTIEPRTF 119

  Fly   381 NRDKSQLEIDCWQKNLTTIPSLP-----VPKKGSSALVFQSNLLA-------------------- 420
            ...::..|::.....:||:|.||     :....::.||..:|.||
Mouse   120 LAMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPC 184

  Fly   421 ----ELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNV 481
                ::...:|.|..||..|.:.||.||.:. .|||.||.||.:.:|.|..|.|:.:..|.|:.|
Mouse   185 TGAVKVTPGALLGLSNLTHLSLKYNNLTKVP-RQLPPSLEYLLVSYNLIVKLGPEDLANLTSLRV 248

  Fly   482 FNQYGNKWSIYCD------------EYHLQ-EFFWYKAKL--LRIKTSKFQTI----------ME 521
            .:..||  ...||            ..||. |.|.:.:.|  |.:|.|...|:          :.
Mouse   249 LDVGGN--CRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLS 311

  Fly   522 YIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEII 586
            .::||      |||                               |.|::.|     :..|..:.
Mouse   312 VLDLS------ENF-------------------------------LYESITH-----TNAFQNLT 334

  Fly   587 -LHHLNSPCPYRCSCCF-EWHTG---EFLINCRNLSLD-IYPRLPNSIPYKTTLYLDRNEIRKLT 645
             |..||....||....| ..|..   :.|::.:.|::: |:.||           |::..:|.|.
Mouse   335 RLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRL-----------LNKYTLRWLA 388

  Fly   646 NTESLVVAGHASIHKLHMSQNLLRELPLHLLP--ENITYLDVRNNLLKYLDDGVIAFLEYRENIT 708
            :...|        |.||:..|.:.:..|.:..  ..:.::|:.:|.:........|..|..::..
Mouse   389 DLPKL--------HTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAE 445

  Fly   709 KIE-LSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPE-----DCICCVDTSNSDS 767
            :.| ||.:|........|..:|:.|.:..::...|.|..:...| ||     ..:.|:..|: :|
Mouse   446 QEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIK-PEMFVNLSRLQCLSLSH-NS 508

  Fly   768 LAYVVDCS----------------------GKELSEIPQLPTPTYGQTT---------------- 794
            :|..|:.|                      .|..||:|||........:
Mouse   509 IAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVT 573

  Fly   795 ------------------------------LVFERNSL-KKWPSS-----LLPGYSSVTRFYLAH 823
                                          |.|..|.: :.|...     ...|.|.:.:..|:.
Mouse   574 HLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQ 638

  Fly   824 NRL-----SDIDQLP------------------------DKLEYLDISNNNFSALDDRV--RGFL 857
            |.|     .::|.||                        ..||.||::.|...||.:..  .|.|
Mouse   639 NNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTL 703

  Fly   858 QKRMNSSQ-----------------------------LQLSLFG-------------NPWTCRCE 880
            .::::.|.                             :..|.||             ||..|.|.
Mouse   704 LQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACG 768

  Fly   881 DK--DFLVFVKEQAKNIANASAIQCID----TGRSLIEVEETDICPSVLIYYTSLAVSLLIIALS 939
            ..  |.|:.|:.:...:||  .::|..    .|||:. .::..:|...::.:....:|||.:|:.
Mouse   769 AAFVDLLLEVQTKVPGLAN--GVKCGSPGQLQGRSIF-AQDLRLCLDEVLSWDCFGLSLLAVAVG 830

  Fly   940 INVFICFRQPIM-------IWFYEHEICLS----LAARRELDEDKKYDAFLSFTHKDEDLIEEFV 993
            :.|      ||:       :|:..| :||:    ||..|...:...||||:.| .|.:..:.::|
Mouse   831 MVV------PILHHLCGWDVWYCFH-LCLAWLPLLARSRRSAQTLPYDAFVVF-DKAQSAVADWV 887

  Fly   994 -----DRLE--NGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFR 1051
                 .|||  .||...|||...||||.|:::.:.:..|:.|||:.:.::......|...|..|.
Mouse   888 YNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDRVSGLLRTSFL 952

  Fly  1052 LALHATSRDRCKRLI-VVLYPDV--EHFDDLDSELRAYMV----------------LNTYLDRNN 1097
            ||......||...:: |:|.||.  ..:..|...|....|                |:|.|.|:|
Mouse   953 LAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDN 1017

  Fly  1098 PNFWNK 1103
            .:|:|:
Mouse  1018 RHFYNQ 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	1/1 (100%)
		leucine-rich repeat	288..308	CDD:275380	4/19 (21%)
		leucine-rich repeat	309..334	CDD:275380	10/51 (20%)
		leucine-rich repeat	335..386	CDD:275380	8/57 (14%)
		leucine-rich repeat	388..408	CDD:275380	6/24 (25%)
		LRR_8	412..465	CDD:290566	22/76 (29%)
		leucine-rich repeat	412..432	CDD:275378	7/43 (16%)
		LRR_4	432..470	CDD:289563	17/37 (46%)
		leucine-rich repeat	433..454	CDD:275378	9/20 (45%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	5/22 (23%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	4/12 (33%)
		leucine-rich repeat	771..791	CDD:275380	8/41 (20%)
		leucine-rich repeat	793..815	CDD:275378	5/73 (7%)
		leucine-rich repeat	816..835	CDD:275378	6/47 (13%)
		leucine-rich repeat	836..859	CDD:275378	9/24 (38%)
		TIR	974..1110	CDD:214587	45/156 (29%)
Tlr9	NP_112455.2	leucine-rich repeat	43..64	CDD:275380	6/20 (30%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	47..51		0/3 (0%)
		LRR 1	62..85		1/22 (5%)
		LRR_8	63..135	CDD:290566	10/85 (12%)
		leucine-rich repeat	65..88	CDD:275380	1/22 (5%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	72..77		0/4 (0%)
		LRR 2	87..110		7/36 (19%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	95..109		6/18 (33%)
		LRR 3	122..147		6/24 (25%)
		leucine-rich repeat	125..168	CDD:275380	11/42 (26%)
		LRR_8	143..211	CDD:290566	12/67 (18%)
		LRR 4	150..166		5/15 (33%)
		LRR 5	167..190		0/22 (0%)
		leucine-rich repeat	169..200	CDD:275380	2/30 (7%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	179..181		0/1 (0%)
		LRR_RI	<194..373	CDD:238064	54/223 (24%)
		LRR 6	198..221		10/23 (43%)
		LRR_8	199..254	CDD:290566	21/55 (38%)
		leucine-rich repeat	201..221	CDD:275380	9/20 (45%)
		leucine-rich repeat	222..245	CDD:275380	8/22 (36%)
		LRR 7	223..242		6/18 (33%)
		LRR 8	243..268		7/26 (27%)
		leucine-rich repeat	246..285	CDD:275380	9/40 (23%)
		LRR 9	283..306		5/22 (23%)
		LRR_8	284..344	CDD:290566	17/101 (17%)
		leucine-rich repeat	286..309	CDD:275380	5/22 (23%)
		LRR 10	308..332		9/65 (14%)
		leucine-rich repeat	310..335	CDD:275380	9/66 (14%)
		LRR 11	333..356		6/22 (27%)
		leucine-rich repeat	336..365	CDD:275380	8/28 (29%)
		LRR 12	363..386		6/33 (18%)
		LRR 13	390..413		6/30 (20%)
		leucine-rich repeat	393..411	CDD:275380	6/25 (24%)
		LRR 14	415..440		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..462		6/31 (19%)
		LRR 15	471..495		5/24 (21%)
		leucine-rich repeat	477..498	CDD:275380	5/21 (24%)
		LRR_RI	<490..>641	CDD:238064	22/151 (15%)
		LRR_8	497..556	CDD:290566	12/59 (20%)
		LRR 16	497..520		6/23 (26%)
		leucine-rich repeat	499..523	CDD:275380	6/24 (25%)
		LRR 17	521..544		1/22 (5%)
		leucine-rich repeat	524..547	CDD:275380	3/22 (14%)
		LRR 18	546..573		3/26 (12%)
		leucine-rich repeat	548..577	CDD:275380	1/28 (4%)
		LRR 19	575..599		0/23 (0%)
		leucine-rich repeat	578..600	CDD:275380	0/21 (0%)
		leucine-rich repeat	601..630	CDD:275380	5/28 (18%)
		LRR 20	601..623		4/21 (19%)
		LRR_8	<623..690	CDD:290566	13/66 (20%)
		LRR 21	628..651		4/22 (18%)
		leucine-rich repeat	631..679	CDD:275380	6/47 (13%)
		LRR 22	653..676		1/22 (5%)
		LRR 23	677..700		7/22 (32%)
		leucine-rich repeat	680..703	CDD:275380	8/22 (36%)
		LRR 24	702..724		2/21 (10%)
		leucine-rich repeat	704..752	CDD:275380	4/47 (9%)
		LRR 25	725..748		2/22 (9%)
		LRR 26	750..773		4/22 (18%)
		leucine-rich repeat	753..774	CDD:275380	4/20 (20%)
		TIR_2	870..>974	CDD:304906	33/104 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820