DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and TLR10

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001017388.1	Gene:	TLR10 / 81793	HGNCID:	15634	Length:	811	Species:	Homo sapiens

Alignment Length:	876	Identity:	160/876 - (18%)
Similarity:	297/876 - (33%)	Gaps:	284/876 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 DKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLS 447
            ::.:|..:|...:|..:|:...|  .::.|....|||.:|..:.......|:.|.:.:|::..|.
Human    26 EERELMTNCSNMSLRKVPADLTP--ATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLD 88

  Fly   448 VS--QLPESLHYLDIRHNKITTLSPQVVEYLYSVNV-FNQYGNKWSIYCDE----YHLQ------ 499
            :.  :..:.|.|||:.:|::.:::..::..|..::: ||.:..  ...|:|    .||:
Human    89 LKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDT--MPICEEAGNMSHLEILGLSG 151

  Fly   500 ------EF-------------------------------------------FWYKAKLLR--IKT 513
                  :|                                           ||.   |||  |||
Human   152 AKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWV---LLRDGIKT 213

  Fly   514 SKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLF 578
            ||   |:|...:..|..||.....:|   |.||..:..::                .||....|:
Human   214 SK---ILEMTNIDGKSQFVSYEMQRN---LSLENAKTSVL----------------LLNKVDLLW 256

  Fly   579 SGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRK 643
            ...|  :||.             |.|||.......||            :.:....|||.|....
Human   257 DDLF--LILQ-------------FVWHTSVEHFQIRN------------VTFGGKAYLDHNSFDY 294

  Fly   644 LTNTESLVVAGHASIHKLHMSQN----LLRELPL-----------HLL----PENITYLDVRNNL 689
            .......:...|......::.|:    ||.::.:           |:|    |....||:..||:
Human   295 SNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNI 359

  Fly   690 LKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPE 754
               |.|.:........::..:.|:||..|    ..:.:|....:.|:|:..:.:  .:...|..|
Human   360 ---LTDELFKRTIQLPHLKTLILNGNKLE----TLSLVSCFANNTPLEHLDLSQ--NLLQHKNDE 415

  Fly   755 DCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRF 819
            :|                                               .||       .:|...
Human   416 NC-----------------------------------------------SWP-------ETVVNM 426

  Fly   820 YLAHNRLSD--IDQLPDKLEYLDISNN----------------------NF-------------S 847
            .|::|:|||  ...||..::.||::||                      ||             |
Human   427 NLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLS 491

  Fly   848 ALDDRVRGFLQKRMNSSQ-----LQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDT- 906
            .|:..:...|...::..|     ..|:...||:.|.||.|:|:     |.:..:....:...|:
Human   492 VLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFI-----QLETYSEVMMVGWSDSY 551

  Fly   907 ---------GRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFIC--FRQPIMIWFYE---- 956
                     |..|.:|...::..:..:...::.|.:|::.|:: .|.|  |..|   |:..
Human   552 TCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAV-AFCCLHFDLP---WYLRMLGQ 612

  Fly   957 -----HEICLSLAARRELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLRDWLVG 1015
                 |.:  ....:.:|..:.::.||:|::..|...:: |.:..||.......:|.|...:..|
Human   613 CTQTWHRV--RKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPG 675

  Fly  1016 ESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHF--DD 1078
            :||.:.|...::.|.:.|.:::.||:::.|...||..|.|....:....:|::|...:..:  ..
Human   676 KSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPT 740

  Fly  1079 LDSELRAYMVLNTYLD-----RNNPNFWNKL 1104
            ...:|:|.:....||:     |....||..|
Human   741 RYHKLKALLEKKAYLEWPKDRRKCGLFWANL 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	0/2 (0%)
		leucine-rich repeat	388..408	CDD:275380	4/19 (21%)
		LRR_8	412..465	CDD:290566	14/54 (26%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	9/39 (23%)
		leucine-rich repeat	433..454	CDD:275378	4/22 (18%)
		leucine-rich repeat	455..478	CDD:275378	6/22 (27%)
		leucine-rich repeat	479..490	CDD:275378	2/11 (18%)
		leucine-rich repeat	632..657	CDD:275378	5/24 (21%)
		leucine-rich repeat	658..679	CDD:275378	6/39 (15%)
		leucine-rich repeat	680..706	CDD:275378	6/25 (24%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	0/19 (0%)
		leucine-rich repeat	793..815	CDD:275378	2/21 (10%)
		leucine-rich repeat	816..835	CDD:275378	8/20 (40%)
		leucine-rich repeat	836..859	CDD:275378	9/57 (16%)
		TIR	974..1110	CDD:214587	32/139 (23%)
TLR10	NP_001017388.1	LRR 1	24..46		4/19 (21%)
		LRR 2	49..70		5/20 (25%)
		leucine-rich repeat	50..73	CDD:275378	5/22 (23%)
		LRR_8	72..129	CDD:316378	12/56 (21%)
		LRR 3	73..94		4/20 (20%)
		leucine-rich repeat	74..97	CDD:275378	4/22 (18%)
		LRR 4	97..118		5/20 (25%)
		leucine-rich repeat	98..112	CDD:275378	5/13 (38%)
		leucine-rich repeat	119..143	CDD:275378	5/25 (20%)
		LRR 5	119..139		5/21 (24%)
		LRR 6	143..166		3/22 (14%)
		leucine-rich repeat	144..155	CDD:275378	1/10 (10%)
		LRR	289..>522	CDD:227223	45/295 (15%)
		LRR 7	296..321		2/24 (8%)
		LRR 8	325..348		2/22 (9%)
		LRR 9	349..368		6/21 (29%)
		leucine-rich repeat	350..373	CDD:275380	6/25 (24%)
		LRR 10	373..394		5/24 (21%)
		leucine-rich repeat	374..398	CDD:275380	5/27 (19%)
		LRR 11	398..419		5/69 (7%)
		leucine-rich repeat	399..422	CDD:275380	6/78 (8%)
		LRR 12	422..442		6/19 (32%)
		leucine-rich repeat	423..444	CDD:275380	8/20 (40%)
		LRR 13	444..465		4/20 (20%)
		leucine-rich repeat	445..467	CDD:275380	4/21 (19%)
		LRR 14	467..488		2/20 (10%)
		leucine-rich repeat	468..490	CDD:275380	2/21 (10%)
		LRR 15	489..509		3/19 (16%)
		leucine-rich repeat	491..513	CDD:275380	4/21 (19%)
		LRRCT	522..574	CDD:214507	12/56 (21%)
		TIR	633..775	CDD:214587	32/139 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920