DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and AT2G33170

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001323641.1	Gene:	AT2G33170 / 817878	AraportID:	AT2G33170	Length:	1124	Species:	Arabidopsis thaliana

Alignment Length:	956	Identity:	185/956 - (19%)
Similarity:	289/956 - (30%)	Gaps:	400/956 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WT-----SDGQ----------QQQQQQLGWCNNKDDPP--------NSHQKSKSNNDARNLNSRV 61
            ||     ||||          |....:|...|..|:.|        :|...|.|:|.
plant    28 WTSESLNSDGQFLLELKNRGFQDSLNRLHNWNGIDETPCNWIGVNCSSQGSSSSSNS-------- 84

  Fly    62 RVRARVRVVPGEMRMGDINCS-------NGLGNIREDYCEIYL---------DELGENGTCSIAN 110
                   :|...:.:..:|.|       .||.|:      :||         |...|.|.||
plant    85 -------LVVTSLDLSSMNLSGIVSPSIGGLVNL------VYLNLAYNALTGDIPREIGNCS--- 133

  Fly   111 NEVTTEDYQMKLVFLK---------LEINWTSPVFHGWNIFKICNETDYELVIISVLGIRSEVDM 166
                    :::::||.         :|||..|.:    ..|.|||.
plant   134 --------KLEVMFLNNNQFGGSIPVEINKLSQL----RSFNICNN------------------- 167

  Fly   167 RIS-PAVQYL-SLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIR 229
            ::| |..:.: .|..:.|:..|...|...|...:    .|..|:.||:...:....::.|.  |.
plant   168 KLSGPLPEEIGDLYNLEELVAYTNNLTGPLPRSL----GNLNKLTTFRAGQNDFSGNIPTE--IG 226

  Fly   230 KTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGK--------NKMSALIFNGLKIKGLTNNTFENLT 286
            |.:|    :|:          |.:.:|...|:        .|:..:|....|..|.......|||
plant   227 KCLN----LKL----------LGLAQNFISGELPKEIGMLVKLQEVILWQNKFSGFIPKDIGNLT 277

  Fly   287 SLNTL-IFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFT 350
            ||.|| ::.|..:..:.               .::.||..||....:.|
plant   278 SLETLALYGNSLVGPIP---------------SEIGNMKSLKKLYLYQN---------------- 311

  Fly   351 AFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQL----EIDCWQKNLTTIPSLPVPKKGSSA 411
                                    :.|.:..::..:|    ||| :.:||.: ..:||.....|.
plant   312 ------------------------QLNGTIPKELGKLSKVMEID-FSENLLS-GEIPVELSKISE 350

  Fly   412 L----VFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLP------ESLHYLDIRHNKIT 466
            |    :||:.|...:| |.|....||..||:|.|.||    ..:|      .|:..|.:.||.::
plant   351 LRLLYLFQNKLTGIIP-NELSKLRNLAKLDLSINSLT----GPIPPGFQNLTSMRQLQLFHNSLS 410

  Fly   467 TLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSF 531
            .:.||.:         ..|...|.:...|.                           :||.|
plant   411 GVIPQGL---------GLYSPLWVVDFSEN---------------------------QLSGK--- 436

  Fly   532 VENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPY 596
            :..|..|..:.:.|....:.|   ||      |:                          .|...
plant   437 IPPFICQQSNLILLNLGSNRI---FG------NI--------------------------PPGVL 466

  Fly   597 RCSCCFEWH------TGEF------LINCRNLSLDIYPRLPNSIPYK--TTLYLDR--------- 638
            ||....:..      ||:|      |:|...:.|| ..|....:|.:  |...|.|
plant   467 RCKSLLQLRVVGNRLTGQFPTELCKLVNLSAIELD-QNRFSGPLPPEIGTCQKLQRLHLAANQFS 530

  Fly   639 ----NEIRKLTN-------TESLV------VAGHASIHKLHMSQN-----------LLRELPLHL 675
                |||.||:|       :.||.      :|....:.:|.:|:|           .|.:|.:..
plant   531 SNLPNEISKLSNLVTFNVSSNSLTGPIPSEIANCKMLQRLDLSRNSFIGSLPPELGSLHQLEILR 595

  Fly   676 LPEN---------------ITYLDVRNNLLK-----YLDDGVIAFLEYRENITKIELSGN--PWE 718
            |.||               :|.|.:..||..     .|  |:::.|:...|::..:.||.  |..
plant   596 LSENRFSGNIPFTIGNLTHLTELQMGGNLFSGSIPPQL--GLLSSLQIAMNLSYNDFSGEIPPEI 658

  Fly   719 CNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIP 783
            .|.....:||....|...|..|..                       ::|:.::.|:....:...
plant   659 GNLHLLMYLSLNNNHLSGEIPTTF-----------------------ENLSSLLGCNFSYNNLTG 700

  Fly   784 QLP-TPTYGQTTLV-FERN-------------SLKKWP--SSLLPG 812
            ||| |..:...||. |..|             |...||  |||..|
plant   701 QLPHTQIFQNMTLTSFLGNKGLCGGHLRSCDPSHSSWPHISSLKAG 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..308	CDD:275380	4/20 (20%)
		leucine-rich repeat	309..334	CDD:275380	4/24 (17%)
		leucine-rich repeat	335..386	CDD:275380	1/50 (2%)
		leucine-rich repeat	388..408	CDD:275380	7/19 (37%)
		LRR_8	412..465	CDD:290566	20/62 (32%)
		leucine-rich repeat	412..432	CDD:275378	7/23 (30%)
		LRR_4	432..470	CDD:289563	13/43 (30%)
		leucine-rich repeat	433..454	CDD:275378	8/26 (31%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	12/50 (24%)
		leucine-rich repeat	658..679	CDD:275378	6/31 (19%)
		leucine-rich repeat	680..706	CDD:275378	7/30 (23%)
		leucine-rich repeat	707..719	CDD:275378	3/13 (23%)
		leucine-rich repeat	771..791	CDD:275380	5/20 (25%)
		leucine-rich repeat	793..815	CDD:275378	11/36 (31%)
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
AT2G33170	NP_001323641.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000