DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and TLR4

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:997 Identity:203/997 - (20%)
Similarity:365/997 - (36%) Gaps:260/997 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 PAVQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNN 234
            ||:.:||.:...........:|::....|:::....|..:.|     ||.|..::.|.:|     
Human    13 PAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPF-----STKNLDLSFNPLR----- 67

  Fly   235 TEKIKIYYHNTFEKTTL---------TMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNT 290
              .:..|...:|.:..:         |:|...:...:.:|.||..|..|:.|....|..|:||..
Human    68 --HLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQK 130

  Fly   291 LI--------FDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFK 347
            |:        .:|..:..|..|:...:..:|      :.:....:.|...||||.:::|..|   
Human   131 LVAVETNLASLENFPIGHLKTLKELNVAHNL------IQSFKLPEYFSNLTNLEHLDLSSNK--- 186

  Fly   348 NFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSAL 412
                               |..:.|                     .:|..:..:|:        
Human   187 -------------------IQSIYC---------------------TDLRVLHQMPL-------- 203

  Fly   413 VFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPE-SLHYLDIRHNKITTLSPQVVEYL 476
               .||                |||:|.|.:..:......| .||.|.:|:|            .
Human   204 ---LNL----------------SLDLSLNPMNFIQPGAFKEIRLHKLTLRNN------------F 237

  Fly   477 YSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNID 541
            .|:||...        |    :|.....:...|.:...:.:..:|..:.|:..... |..::...
Human   238 DSLNVMKT--------C----IQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLC-NLTIEEFR 289

  Fly   542 QLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHT 606
            ..||:...|:|||.|.......:..|:......:..||..|.                    |..
Human   290 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFG--------------------WQH 334

  Fly   607 GEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLREL 671
            .| |:||:      :.:.|       ||.|  ..:::||.|.             :...|...|:
Human   335 LE-LVNCK------FGQFP-------TLKL--KSLKRLTFTS-------------NKGGNAFSEV 370

  Fly   672 PLHLLPENITYLDV-RNNL---------------LKYLD---DGVIA----FLEYRENITKIELS 713
            .|    .::.:||: ||.|               |||||   :|||.    ||.. |.:..::..
Human   371 DL----PSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGL-EQLEHLDFQ 430

  Fly   714 GNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKE 778
            .:..:...:...|||             ||.:...|.......:......|..|...|:..:|..
Human   431 HSNLKQMSEFSVFLS-------------LRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNS 482

  Fly   779 LSE--IPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDK----LE 837
            ..|  :|.:.|.....|.|...:..|::...:.....||:....::||....:|..|.|    |:
Human   483 FQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQ 547

  Fly   838 YLDIS-NNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAI 901
            .||.| |:..::....::.|     .||...|:|..|.:.|.||.:.||.::|:|.:.:.....:
Human   548 VLDYSLNHIMTSKKQELQHF-----PSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERM 607

  Fly   902 QCI----DTGRSLIEVEETDICPSVLIYYTSLAVSLL-IIALSINVFICFRQPIMIWFYEHEICL 961
            :|.    ..|..::.:..|  |.   :..|.:.||:| ::.:|:...:.::      ||.|.:.|
Human   608 ECATPSDKQGMPVLSLNIT--CQ---MNKTIIGVSVLSVLVVSVVAVLVYK------FYFHLMLL 661

  Fly   962 SLAARRELDEDKKYDAFLSFTHKDEDLI-EEFVDRLENGRHKFRLCFYLRDWLVGESI-PDCINQ 1024
            :...:....|: .||||:.::.:|||.: .|.|..||.|...|:||.:.||::.|.:| .:.|::
Human   662 AGCIKYGRGEN-IYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHE 725

  Fly  1025 SVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVL 1089
            ....||::|::::::|::|.|...|:.:|...........:|.::...||. ..|..::..|.:|
Human   726 GFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEK-TLLRQQVELYRLL 789

  Fly  1090 --NTYLDRNNP-----NFWNKL 1104
              ||||:..:.     .||.:|
Human   790 SRNTYLEWEDSVLGRHIFWRRL 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 8/22 (36%)
leucine-rich repeat 288..308 CDD:275380 5/27 (19%)
leucine-rich repeat 309..334 CDD:275380 2/24 (8%)
leucine-rich repeat 335..386 CDD:275380 6/50 (12%)
leucine-rich repeat 388..408 CDD:275380 2/19 (11%)
LRR_8 412..465 CDD:290566 13/53 (25%)
leucine-rich repeat 412..432 CDD:275378 2/19 (11%)
LRR_4 432..470 CDD:289563 11/38 (29%)
leucine-rich repeat 433..454 CDD:275378 6/21 (29%)
leucine-rich repeat 455..478 CDD:275378 5/22 (23%)
leucine-rich repeat 479..490 CDD:275378 2/10 (20%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 3/20 (15%)
leucine-rich repeat 680..706 CDD:275378 15/48 (31%)
leucine-rich repeat 707..719 CDD:275378 0/11 (0%)
leucine-rich repeat 771..791 CDD:275380 5/21 (24%)
leucine-rich repeat 793..815 CDD:275378 3/21 (14%)
leucine-rich repeat 816..835 CDD:275378 4/18 (22%)
leucine-rich repeat 836..859 CDD:275378 6/23 (26%)
TIR 974..1110 CDD:214587 41/140 (29%)
TLR4NP_612564.1 LRR_RI 55..>195 CDD:238064 33/195 (17%)
LRR 1 55..76 6/27 (22%)
leucine-rich repeat 56..79 CDD:275378 6/29 (21%)
LRR_8 57..114 CDD:290566 11/63 (17%)
LRR 2 79..100 2/20 (10%)
leucine-rich repeat 80..103 CDD:275378 2/22 (9%)
LRR_8 102..187 CDD:290566 22/112 (20%)
LRR 3 103..124 7/20 (35%)
leucine-rich repeat 104..127 CDD:275378 8/22 (36%)
LRR 4 127..148 4/20 (20%)
leucine-rich repeat 128..176 CDD:275378 7/53 (13%)
leucine-rich repeat 130..151 CDD:275380 3/20 (15%)
LRR 5 151..172 2/26 (8%)
LRR_RI 152..456 CDD:238064 83/471 (18%)
LRR 6 176..199 8/65 (12%)
leucine-rich repeat 177..190 CDD:275378 5/34 (15%)
leucine-rich repeat 195..224 CDD:275380 9/55 (16%)
LRR 7 205..225 7/35 (20%)
LRR 8 227..247 9/43 (21%)
LRR 9 331..351 9/55 (16%)
LRR 10 352..373 6/37 (16%)
leucine-rich repeat 353..374 CDD:275380 6/37 (16%)
LRR_RI <372..581 CDD:238064 51/231 (22%)
LRR 11 374..394 5/19 (26%)
LRR_8 399..458 CDD:290566 17/72 (24%)
LRR 12 400..422 10/22 (45%)
leucine-rich repeat 401..423 CDD:275380 10/22 (45%)
LRR 13 423..444 0/20 (0%)
leucine-rich repeat 424..448 CDD:275380 4/36 (11%)
LRR_8 447..508 CDD:290566 11/60 (18%)
LRR 14 448..456 1/7 (14%)
leucine-rich repeat 449..472 CDD:275380 2/22 (9%)
LRR 15 472..495 5/22 (23%)
leucine-rich repeat 473..497 CDD:275380 5/23 (22%)
LRR 16 497..518 3/20 (15%)
leucine-rich repeat 498..521 CDD:275380 3/22 (14%)
LRR_8 520..581 CDD:290566 18/65 (28%)
LRR 17 521..542 5/20 (25%)
LRR 18 545..565 5/19 (26%)
leucine-rich repeat 546..570 CDD:275380 6/28 (21%)
LRRCT 579..625 CDD:214507 10/45 (22%)
TIR 674..815 CDD:214587 41/139 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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