| Sequence 1: | NP_523519.2 | Gene: | Toll-4 / 34235 | FlyBaseID: | FBgn0032095 | Length: | 1125 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001305716.1 | Gene: | TLR2 / 7097 | HGNCID: | 11848 | Length: | 784 | Species: | Homo sapiens |
| Alignment Length: | 892 | Identity: | 190/892 - (21%) |
|---|---|---|---|
| Similarity: | 327/892 - (36%) | Gaps: | 297/892 - (33%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 379 SYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQL 443
Fly 444 TSLSVSQLPE--------------------------SLHYLDIRHNKITTLSPQVVEYLYSVNVF 482
Fly 483 NQYGNKW------SIYCDEYHLQEFFWYKAKLLRIKT----SKFQ-------TIMEYIELSSKGS 530
Fly 531 FVENF------FVQNIDQLYLEANE---------------------DEIIDAFGPSD-------- 560
Fly 561 --KYF---NLKL--------MEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLIN 612
Fly 613 CRNLSLDIYPRLPNSIPYKTT---------LYLDRNEIRKLTNTESLVVAGHASIHKLH--MSQN 666
Fly 667 LLRELPLHLLPENITYLDVRNNLL--KYLDDGV-----------------IAFLEYR-------E 705
Fly 706 NITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAY 770
Fly 771 VVDCSGKELS----EIPQLPTPTYGQTTLVFERNSLKKWP-SSLLPGYSSVTRFYLAHNRLSDID 830
Fly 831 QLPDKLEYLDISNNNFSALDDRVRGFLQKRMNS--SQLQLSLFGNPWTCRCEDKDFLVFVKEQ-- 891
Fly 892 -AKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVF----ICFR---- 947
Fly 948 -QPIMIWFYEHEICLSLAARRELDEDKK-------YDAFLSFTHKDEDLIEE-FVDRLENGRHKF 1003
Fly 1004 RLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLE-----FRLALHATSRDRCK 1063
Fly 1064 RLIVVLYP-DVEHFDDLDSELRAYMVLNTYL-----DRNNPNFWNKL 1104 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Toll-4 | NP_523519.2 | leucine-rich repeat | 264..287 | CDD:275380 | |
| leucine-rich repeat | 288..308 | CDD:275380 | |||
| leucine-rich repeat | 309..334 | CDD:275380 | |||
| leucine-rich repeat | 335..386 | CDD:275380 | 1/6 (17%) | ||
| leucine-rich repeat | 388..408 | CDD:275380 | 1/19 (5%) | ||
| LRR_8 | 412..465 | CDD:290566 | 19/78 (24%) | ||
| leucine-rich repeat | 412..432 | CDD:275378 | 4/19 (21%) | ||
| LRR_4 | 432..470 | CDD:289563 | 16/63 (25%) | ||
| leucine-rich repeat | 433..454 | CDD:275378 | 10/46 (22%) | ||
| leucine-rich repeat | 455..478 | CDD:275378 | 7/22 (32%) | ||
| leucine-rich repeat | 479..490 | CDD:275378 | 3/16 (19%) | ||
| leucine-rich repeat | 632..657 | CDD:275378 | 5/33 (15%) | ||
| leucine-rich repeat | 658..679 | CDD:275378 | 3/22 (14%) | ||
| leucine-rich repeat | 680..706 | CDD:275378 | 10/51 (20%) | ||
| leucine-rich repeat | 707..719 | CDD:275378 | 4/11 (36%) | ||
| leucine-rich repeat | 771..791 | CDD:275380 | 6/23 (26%) | ||
| leucine-rich repeat | 793..815 | CDD:275378 | 9/22 (41%) | ||
| leucine-rich repeat | 816..835 | CDD:275378 | 0/18 (0%) | ||
| leucine-rich repeat | 836..859 | CDD:275378 | 6/22 (27%) | ||
| TIR | 974..1110 | CDD:214587 | 43/150 (29%) | ||
| TLR2 | NP_001305716.1 | PLN00113 | <40..>206 | CDD:331614 | 41/178 (23%) |
| leucine-rich repeat | 54..77 | CDD:275380 | 10/22 (45%) | ||
| LRR 1 | 54..77 | 10/22 (45%) | |||
| LRR_8 | 77..135 | CDD:316378 | 11/57 (19%) | ||
| leucine-rich repeat | 78..101 | CDD:275380 | 0/22 (0%) | ||
| LRR 2 | 78..101 | 0/22 (0%) | |||
| leucine-rich repeat | 102..125 | CDD:275380 | 7/22 (32%) | ||
| LRR 3 | 102..125 | 7/22 (32%) | |||
| leucine-rich repeat | 126..150 | CDD:275380 | 6/31 (19%) | ||
| LRR 4 | 126..150 | 6/31 (19%) | |||
| leucine-rich repeat | 151..175 | CDD:275380 | 4/23 (17%) | ||
| LRR 5 | 151..175 | 4/23 (17%) | |||
| LRR 6 | 176..199 | 3/24 (13%) | |||
| leucine-rich repeat | 176..196 | CDD:275380 | 3/21 (14%) | ||
| LRR 7 | 200..223 | 2/22 (9%) | |||
| LRR 8 | 224..250 | 4/25 (16%) | |||
| LRR 9 | 251..278 | 7/26 (27%) | |||
| LRR 10 | 279..308 | 9/49 (18%) | |||
| LRR 11 | 309..337 | 5/27 (19%) | |||
| NEL | <324..>558 | CDD:330839 | 62/301 (21%) | ||
| LRR 12 | 338..361 | 3/32 (9%) | |||
| leucine-rich repeat | 362..388 | CDD:275380 | 7/25 (28%) | ||
| LRR 13 | 362..388 | 7/25 (28%) | |||
| leucine-rich repeat | 389..414 | CDD:275380 | 3/24 (13%) | ||
| LRR 14 | 389..414 | 3/24 (13%) | |||
| leucine-rich repeat | 415..437 | CDD:275380 | 7/33 (21%) | ||
| LRR 15 | 415..437 | 7/33 (21%) | |||
| leucine-rich repeat | 438..478 | CDD:275380 | 5/45 (11%) | ||
| LRR 16 | 438..457 | 1/18 (6%) | |||
| LRR 17 | 458..478 | 4/25 (16%) | |||
| leucine-rich repeat | 479..500 | CDD:275380 | 10/50 (20%) | ||
| LRR 18 | 479..500 | 10/50 (20%) | |||
| leucine-rich repeat | 501..524 | CDD:275380 | 7/29 (24%) | ||
| LRR 19 | 501..524 | 7/29 (24%) | |||
| LRRCT | 533..586 | CDD:214507 | 16/55 (29%) | ||
| TIR | 640..784 | CDD:214587 | 42/143 (29%) | ||
| ATG16L1-binding motif | 761..778 | 4/16 (25%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG4641 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D147327at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000239 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR24365 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X221 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 6 | 5.920 | |||||