DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr8

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001094479.1	Gene:	Tlr8 / 684440	RGDID:	1590327	Length:	1029	Species:	Rattus norvegicus

Alignment Length:	1064	Identity:	244/1064 - (22%)
Similarity:	388/1064 - (36%)	Gaps:	283/1064 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 KMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNG 271
            |.||...|.|:|:.. |||...:|..|.| ||.: .||.         |.....:||      ||
  Rat    60 KYVTDVDLSDNTIMH-ITNESFQKFRNLT-KINL-NHNA---------KQQHPNENK------NG 106

  Fly   272 LKIKGLTNNTFENLTSLNTLIF-DNVF----------LKDLSFLRSSTLQ--SSLTY-------- 315
            :.|   |...|.:|.:|..|:. ||..          ||:||.::::..|  .:.|:
  Rat   107 MNI---TEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERL 168

  Fly   316 -----CIMKVDNM--VDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEP---------YKSHCKFT 364
                 |..|.:.:  |:..:|....||:::.:|    |.|.  |...|         :.|:.|.:
  Rat   169 YLGWNCYFKCNQIFKVEDGAFNNLINLKLLSLS----FNNL--FSVPPKLPSSLSKLFLSNAKIS 227

  Fly   365 LGINE--------VACPLKCNC--SYNRDKSQLEIDCWQKNLT-TIPSLPVPKKGSSALVF---Q 415
            ....|        :...|..||  .:|     ....|...||: :|...|:..:..:.|.|   .
  Rat   228 TITQEDFKGLEHLILLDLSGNCPRCFN-----APFPCESCNLSASIRIHPLAFQNLTQLRFLNLS 287

  Fly   416 SNLLAELPDNSLEGYHNLKSLDVSYNQL-----TSLSVSQLPESLHYLDIRHNKITTLSPQVVEY 475
            |..|..:|....:...|||.|.:.:|.|     :...:::|| ||..||:..|.|..      ||
  Rat   288 STSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLP-SLQTLDLSFNFIHK------EY 345

  Fly   476 LYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQ-- 538
            |..:.:...:....|:  .:.||:.:.:.:.|....|  ..|.:.....::...:|:|....:
  Rat   346 LQYITISPNFSMLRSL--RKLHLKGYVFRELKKEHFK--PLQNLPNLTTINLGINFIEKIDFKAF 406

  Fly   539 ----NIDQLYLEANE-DEIIDAFGPSDKYFNLKLMEALNHAIWL------FSGEFDEIILH---- 588
                |:..:||..|. ..:||               ..:|:.|.      .|.::||...|
  Rat   407 QDFPNLKVIYLSGNRIASVID---------------GTDHSSWRNRLRKPLSTDYDEFDPHMNFY 456

  Fly   589 HLNSPCPYRCSCCFEWHTGEFLIN-----------------CRNLSLDIYPRLPN-----SIPYK 631
            |...|. .:..|.......:..:|                 |.|||.:...::.|     |:|:.
  Rat   457 HSTEPL-IKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQVLNGTEFSSMPHI 520

  Fly   632 TTLYLDRN----------------EIRKLT-NTESLVVAGHASIHKLHMSQNLLRELPLHLLPEN 679
            ..|.|..|                |:..|: |.....:||  ..|:|...|||::...|:|....
  Rat   521 KYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAG--VTHRLGFIQNLIKLKVLNLSHNG 583

  Fly   680 I-TYLD---VRNNLLKYL-------------DDGVI-AFLEYRENITKIELSGNPWECNCKAKAF 726
            | |..|   :::..||.|             :||.. :.....|.:|:::||.|..: ....:||
  Rat   584 IYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQ-QIPNEAF 647

  Fly   727 LSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYG 791
            |:.     |..    |:.:.|.|::        :...|...|.|           .|.|.....|
  Rat   648 LNL-----PQS----LQELHINDNR--------LRFFNWTLLQY-----------FPHLHVLDLG 684

  Fly   792 QTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLP-------DKLEYLDISNNNFSAL 849
            :..|.|..|.|.|:..||       ....|.||..|   .||       ..|.|||:|.|..
  Rat   685 RNELYFLTNCLSKFTHSL-------KTLLLNHNHFS---HLPAGFLSEARNLVYLDLSFNTI--- 736

  Fly   850 DDRVRGFLQKRMNSSQLQ---------LSLFGNPWTCRCEDKDFLVFVKEQAK-NIANASAIQCI 904
                     |.:|.|.||         |.|.||.:.|.|:..||..:::|... .|.....:.|.
  Rat   737 ---------KMINKSSLQTETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICS 792

  Fly   905 DTG----RSLIEVEET----DICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICL 961
            :.|    :|::.::.|    |...::|.::|.|..|.:::|..::....:.    :||..|....
  Rat   793 NPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWD----VWFIYHMCSA 853

  Fly   962 SLAARRELDEDKK-YDAFLSFTHKDED----LIEEFVDRLENGRHK-FRLCFYLRDWLVGESIPD 1020
            .|...|.....:. |||::|:..||..    :|.|....||....| ..||...|||..|..|.|
  Rat   854 KLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIID 918

  Fly  1021 CINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRA 1085
            .:.||:..|::.|.::||.:.||...:..|.|||.....:....:|.:|...|..:... ..||.
  Rat   919 NLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQY-LRLRQ 982

  Fly  1086 YMVLNTYLD-RNNPN----FWNKL 1104
            .:..::.|. .|||.    ||..|
  Rat   983 RICKSSILQWPNNPKAENLFWQSL 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..308	CDD:275380	8/30 (27%)
		leucine-rich repeat	309..334	CDD:275380	6/41 (15%)
		leucine-rich repeat	335..386	CDD:275380	13/69 (19%)
		leucine-rich repeat	388..408	CDD:275380	5/20 (25%)
		LRR_8	412..465	CDD:290566	18/60 (30%)
		leucine-rich repeat	412..432	CDD:275378	5/22 (23%)
		LRR_4	432..470	CDD:289563	14/42 (33%)
		leucine-rich repeat	433..454	CDD:275378	7/25 (28%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	8/41 (20%)
		leucine-rich repeat	658..679	CDD:275378	7/20 (35%)
		leucine-rich repeat	680..706	CDD:275378	8/43 (19%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	7/21 (33%)
		leucine-rich repeat	816..835	CDD:275378	6/25 (24%)
		leucine-rich repeat	836..859	CDD:275378	6/22 (27%)
		TIR	974..1110	CDD:214587	43/142 (30%)
Tlr8	NP_001094479.1	PRK15370	<21..>218	CDD:185268	46/184 (25%)
		leucine-rich repeat	62..85	CDD:275380	9/23 (39%)
		leucine-rich repeat	86..119	CDD:275380	14/52 (27%)
		leucine-rich repeat	120..140	CDD:275380	4/19 (21%)
		PLN00113	141..>664	CDD:215061	117/580 (20%)
		leucine-rich repeat	141..164	CDD:275380	6/22 (27%)
		leucine-rich repeat	165..194	CDD:275380	4/28 (14%)
		leucine-rich repeat	195..215	CDD:275380	6/25 (24%)
		leucine-rich repeat	216..239	CDD:275380	3/22 (14%)
		leucine-rich repeat	240..280	CDD:275380	9/44 (20%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..324	CDD:275380	5/18 (28%)
		leucine-rich repeat	331..387	CDD:275380	14/65 (22%)
		leucine-rich repeat	388..411	CDD:275380	2/22 (9%)
		leucine-rich repeat	467..494	CDD:275380	2/26 (8%)
		leucine-rich repeat	495..510	CDD:275380	4/14 (29%)
		leucine-rich repeat	520..543	CDD:275380	3/22 (14%)
		leucine-rich repeat	544..573	CDD:275380	10/30 (33%)
		leucine-rich repeat	574..597	CDD:275380	5/22 (23%)
		leucine-rich repeat	598..628	CDD:275380	5/29 (17%)
		PRK15370	<629..>739	CDD:185268	37/160 (23%)
		leucine-rich repeat	629..653	CDD:275380	8/29 (28%)
		leucine-rich repeat	654..677	CDD:275380	6/41 (15%)
		leucine-rich repeat	678..701	CDD:275380	7/22 (32%)
		leucine-rich repeat	702..725	CDD:275380	7/32 (22%)
		leucine-rich repeat	726..745	CDD:275380	9/30 (30%)
		PCC	730..>813	CDD:188093	22/94 (23%)
		TIR	868..1004	CDD:214587	41/136 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820