Protein Alignment Toll-4 and SIGIRR

DIOPT Version :9

• Sequence 1: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: XP_005253101.1
• Gene: SIGIRR / 59307
• HGNCID: 30575
• Length: 504
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 76/368 - (20%)
• Similarity: 137/368 - (37%)
• Gaps: 100/368 - (27%)

  Fly   806 PSSLLPGYSSVTRFYLA---------------HNRLSDIDQLPDKL-----------EYLDISNN 844
            |..|.|....|.|..|.               |..|..:..|.|.|           ||..:..|
Human     9 PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKAN 73

  Fly   845 NFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRS 909
            ....|...|.|     :|.:..:  ::| .:||..::..|..|..::|...::.:|
Human    74 LSEVLVSSVLG-----VNVTSTE--VYG-AFTCSIQNISFSSFTLQRAGPTSHVAA--------- 121

  Fly   910 LIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYE--HEICLSLAARRELDED 972
                    :..|:|:....|..:||.:...:||        ::|:.:  .|:        |:::.
Human   122 --------VLASLLVLLALLLAALLYVKCRLNV--------LLWYQDAYGEV--------EINDG 162

  Fly   973 KKYDAFLSFTHKDEDLIEEFVD-----RLENGRHKFRLCFYLRDWLV-GESIPDCINQSVKGSRR 1031
            |.|||::|::...||  .:||:     :||. |..::|....||.|. .|...|.: .::...||
Human   163 KLYDAYVSYSDCPED--RKFVNFILKPQLER-RRGYKLFLDDRDLLPRAEPSADLL-VNLSRCRR 223

  Fly  1032 IIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSE--------LRAYMV 1088
            :|::::..||...|....||..|       |:.|.:...|....|:....:        ||.:..
Human   224 LIVVLSDAFLSRAWCSHSFREGL-------CRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRH 281

  Fly  1089 LNTYL------DRNNPNFWNKLMYSMPHASHLKRSRSDAETKV 1125
            |.|.|      ...:.:||.::..::|.....:....|.:|::
Human   282 LVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQL 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378	3/8 (38%)
		leucine-rich repeat	816..835	CDD:275378	6/33 (18%)
		leucine-rich repeat	836..859	CDD:275378	7/33 (21%)
		TIR	974..1110	CDD:214587	37/155 (24%)
SIGIRR	XP_005253101.1	Ig	8..111	CDD:299845	23/109 (21%)
		TIR	165..311	CDD:279864	38/156 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910