DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and LOC572462

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_005167813.2	Gene:	LOC572462 / 572462	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1171	Identity:	240/1171 - (20%)
Similarity:	428/1171 - (36%)	Gaps:	420/1171 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 QMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVLGIR----SEVD-MRI-------SPA 171
            ::|:|.|             :.:|.:|.:|.|   :.|.|..:    |:|: :.|       :..
Zfish     6 KLKMVLL-------------FALFILCPKTCY---VCSWLAEKCHFFSDVEGLNIASFYHGKTSI 54

  Fly   172 VQYLSLLGIRE-ISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNT 235
            .:.||:..|:| :.|....|.::|: :||:|                 .:.|:..|...: ..:.
Zfish    55 AECLSVTDIKEDLRGLPTNLLNLLV-QMDLH-----------------FHGVLAPNSFSR-FGSL 100

  Fly   236 EKIKI----------YYHNTFEKTTLTM----EKNI------FHGKNKMSALIFNGLKIKGLTNN 280
            |.:||          .::.....|:||:    .||.      |.....:::|..:...:..|..|
Zfish   101 ENLKIAGCFSEIPPEAFNGLTNVTSLTITALDSKNCCEVALDFSHLPSLTSLFISHHDLSLLALN 165

  Fly   281 TFENLTSLNTLIFDNVFLKDLS----------FLRSSTLQS---SLTYCIMKVDNMVDLKSFEKF 332
            .||.:..|..|..|:|.|||||          .|:..:|..   .|.|....|.|..|:.:  :|
Zfish   166 VFEKIPHLQWLYLDSVCLKDLSDVLCRLANVKLLKLFSLDDWNIRLQYQNCSVFNTTDIST--EF 228

  Fly   333 T---------NLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLE 388
            :         .||.|:...:|.|...         |...|::.          |..:..|.|.:.
Zfish   229 SIETVDLLLGKLEHIDEGAFKPFGKL---------SLLHFSVS----------NTDFLEDLSLIG 274

  Fly   389 IDCWQKNLTTIPSLPVPKKGSSALVFQSN-----LLAELPDNSLEGYHNLKSLDVSYNQLTSLSV 448
            :....|              .||:|...|     :.|:|        :::||:||.|..: :||:
Zfish   275 VHQISK--------------ISAIVDVLNVDDLCVAAKL--------YSVKSVDVYYKTI-NLSL 316

  Fly   449 SQLP----ESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLL 509
            :...    :.:.|:.:.::    :|.::|..|...:||..:.|..|               |.:.
Zfish   317 TSKGSVGCKEIGYITLEND----ISREIVNLLDVNSVFQIFSNLTS---------------AAIY 362

  Fly   510 R--IKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEA-NEDEIIDAFGPSDKYF---NLKLM 568
            |  ::::.||::.        .|:.:|  |:.:..:.|:. ..|:|:     |.::.   |||.:
Zfish   363 RHVLRSNDFQSLC--------ASYPQN--VKQLINMVLQTIRIDKIV-----SHQFMCFVNLKTL 412

  Fly   569 EALNHAIWLFS-------GEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPN 626
            :.:...|.:|.       .:..|:.||.......:|       ||...|...|.|.|...|
Zfish   413 KLVMSKISVFEDFAFIGLNKLKELNLHRNKISSIHR-------HTFSGLHELRVLDLQENP---- 466

  Fly   627 SIPYKTTLYLDRNEIRKLTNTESLVVAG-----HASIHKLHMSQ-------NL--------LREL 671
                  .:|::.......||..|.::..     :.|:.|||:|.       ||        ||
Zfish   467 ------IIYIEPKSFGHFTNLSSFLLGDLNFPPNMSLIKLHLSDIFGVIPYNLSNVFISSGLR-- 523

  Fly   672 PLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECN---------------- 720
            |:||:..:.|.|   ||.|.....|....:|               :||
Zfish   524 PMHLVIGSNTTL---NNGLNLHIKGQYVIVE---------------DCNSLLLTSVFTLQIQAAY 570

  Fly   721 --CKAKAFLSFLRRHEP----MEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKEL 779
              |:.:    |:.::.|    :|::::.                      ||::.        :|
Zfish   571 MICENE----FIGKYVPSVVSLEFQSMF----------------------SDNIG--------DL 601

  Fly   780 SEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNN 844
            |.|.||    ....||..|:..|...|:..:          :.||.        .|||.|.::|.
Zfish   602 SVINQL----VHLKTLKLEKLDLTNLPNMDI----------MFHNL--------TKLETLILANC 644

  Fly   845 NFSALDDRVRGFLQKRMNS----------------------SQLQ------LSLFGNPWTCRCED 881
            ....||    |.|.|.:.:                      :||:      |.|:     |.|::
Zfish   645 KLFFLD----GSLTKDLKALTKLGLIPKDTVNILQTFVDHLTQLRFVYLEDLDLY-----CSCDN 700

  Fly   882 KDFLVFVKEQAK---NIANASA--IQCIDTGRSLIEVEETDICPSVLIYYT---SLAVSLLIIAL 938
            ...:.::::..|   .::|.|.  ::|:...    ||:..    |.:.|.|   |..:..:..|.
Zfish   701 AWLVSWIRDNRKVEVVMSNPSMQDLKCLTDN----EVDHI----SFVSYVTENCSFDLDFVFFAC 757

  Fly   939 SINVFICFRQPIMI------------------WFYEHEICLSLAARRELDEDKKYDAFLSFTHKD 985
            | :||:|....:::                  ||.|       |.|.:..:..:||||:|::.||
Zfish   758 S-SVFLCIFIVVVLMYKFVGQYFKPFYHIASGWFRE-------AFRMKEKQQYRYDAFVSYSSKD 814

  Fly   986 ED-LIEEFVDRLE-NGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRL 1048
            |. :|||.:..|| .|....|||.:.||:.:|..|.:.|..|:..|||.:.|:::|:|.|.|..:
Zfish   815 EHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGHDIVENITDSIYASRRTLCLVSRNYLNSNWCSV 879

  Fly  1049 EFRLA---LHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVL--NTYLD-----RNNPNFWNK 1103
            |.:||   |....||    ::::::.:......|.|..|...::  .||||     :.:..||::
Zfish   880 EMQLATYRLQVEHRD----ILILVFLETIPSRLLSSHHRLARLVKTRTYLDWPQESKMHEAFWDR 940

  Fly  1104 L 1104
            |
Zfish   941 L 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..308	CDD:275380	10/29 (34%)
		leucine-rich repeat	309..334	CDD:275380	7/36 (19%)
		leucine-rich repeat	335..386	CDD:275380	9/50 (18%)
		leucine-rich repeat	388..408	CDD:275380	1/19 (5%)
		LRR_8	412..465	CDD:290566	12/61 (20%)
		leucine-rich repeat	412..432	CDD:275378	4/24 (17%)
		LRR_4	432..470	CDD:289563	8/41 (20%)
		leucine-rich repeat	433..454	CDD:275378	7/24 (29%)
		leucine-rich repeat	455..478	CDD:275378	4/22 (18%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	4/29 (14%)
		leucine-rich repeat	658..679	CDD:275378	11/35 (31%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	0/11 (0%)
		leucine-rich repeat	771..791	CDD:275380	5/19 (26%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	8/22 (36%)
		TIR	974..1110	CDD:214587	47/143 (33%)
LOC572462	XP_005167813.2	leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..195	CDD:275380	9/21 (43%)
		leucine-rich repeat	196..253	CDD:275380	13/58 (22%)
		leucine-rich repeat	254..350	CDD:275380	23/141 (16%)
		LRR_8	408..467	CDD:316378	16/75 (21%)
		leucine-rich repeat	409..432	CDD:275378	4/22 (18%)
		PLN00113	<427..>516	CDD:331614	22/105 (21%)
		leucine-rich repeat	433..456	CDD:275378	7/29 (24%)
		leucine-rich repeat	457..480	CDD:275378	5/32 (16%)
		leucine-rich repeat	541..584	CDD:275380	6/61 (10%)
		leucine-rich repeat	585..609	CDD:275380	8/57 (14%)
		leucine-rich repeat	610..635	CDD:275380	7/42 (17%)
		leucine-rich repeat	636..659	CDD:275380	9/26 (35%)
		TIR	803..941	CDD:214587	46/141 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920