DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and il1rapl1a

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_021334418.1	Gene:	il1rapl1a / 568868	ZFINID:	ZDB-GENE-061013-249	Length:	1520	Species:	Danio rerio

Alignment Length:	1031	Identity:	187/1031 - (18%)
Similarity:	325/1031 - (31%)	Gaps:	349/1031 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NNKDDPPNSHQKSKSNNDARNLNSRVRVRARVRVVPGEMRMGDIN-------CSNGLGNIREDYC 93
            |..||..||......:.:..||.               :...|:|       |.:.|..:..||.
Zfish   300 NKSDDSCNSCAADHIDKNLLNLG---------------LEEIDVNWSQISDDCKSQLTQLLADYQ 349

  Fly    94 EIY----LD-----------ELGENGTCSIANNEVTTEDYQM----------KLVFLKLEINWTS 133
            :|:    ||           .|.:|....:....|....|:.          |.:..|....:.|
Zfish   350 DIFSKHPLDCGEATGYVHRIRLTDNRPFRLPYRRVPPAHYEKLRQVLTDMEEKGIIRKSSSEYAS 414

  Fly   134 PVFHGWNI---FKICNETDYELVIISVLGIRSEVDMRISP-AVQYLSLLGIREISGYDIYLPSVL 194
            |:...|..   .:||  ||:..     |..|:..|....| ....|:.||           .:..
Zfish   415 PLVMVWKKDGGLRIC--TDFRW-----LNARTMKDAHPLPHQADCLAALG-----------GNCF 461

  Fly   195 ITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFH 259
            .:.||                       :|:.:....|:..:|         :.|..|....: |
Zfish   462 FSTMD-----------------------LTSGFYNIPMSEEDK---------KYTAFTTPLGL-H 493

  Fly   260 GKNKMSALIFNG--------LKIKGLTN----------------NTFENLTSLNTLIFDNV---F 297
            ..|:|...:.|.        |.|.|..|                :..|.|:.|.| :||.:   .
Zfish   494 EYNRMPQGLCNSPASFMRMMLGIFGDLNFSKLLCYLDDLLVFAPSESEALSRLRT-VFDRLRENN 557

  Fly   298 LKDLSFLRSSTLQSSLTYCIMKVDN---MVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKS 359
            || ||..:...|||.:.:....:|:   .||....|..|.:...::....|        |.|...
Zfish   558 LK-LSPKKCHLLQSQVRFLGHIIDSGGVSVDPAKVEVITRMTAHDLMDNDG--------CTPSVK 613

  Fly   360 HCKFTLGI-----------NEVACPL---------------------------------KCNCSY 380
            ..|..||:           :.::.||                                 :|..::
Zfish   614 RIKSFLGMVFYYQHFIPNCSSISKPLFGLTAGQKRRGKLSKERKFQGTYRKLTPADWTTECQVAF 678

  Fly   381 NRDKSQLEIDCWQK-----NLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSY 440
            ::.|:.| ::|...     |...|.|:.....|..|      :|:::|...|:      :..:::
Zfish   679 DKLKTAL-LECVMLAHPDFNEPFILSVDASLDGLGA------VLSQVPKGELQ------ARPIAF 730

  Fly   441 NQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSV-NVFNQY--GNKWSIYCDEYHLQEFF 502
            ...| ||.||.....|.|:....|            :|| ..|:.:  |:|::|:.|...| .:.
Zfish   731 ASKT-LSTSQRRYPAHRLEFMALK------------WSVCEKFSHWLKGHKFTIWTDNNPL-TYI 781

  Fly   503 WYKAKL----LR--IKTSKFQTIMEYI--------ELSSKGSFVENFFVQNIDQLY----LEAN- 548
            ..|.||    ||  .|.:.:...::::        :..|:..|||....:.:::.|    .||:
Zfish   782 LTKPKLDAYELRWVSKLAAYTFDLKHLPGKANVVADTLSRDPFVEPIGRRLLNEPYSYLMQEASG 846

  Fly   549 --EDEIIDAFGPSDKY--------------FNLKLMEAL--NHAIWLFSGEFDEI-ILHHLN--S 592
              ||.:.|.|..|...              :|:..::||  :|..|....|...: ::||:.  |
Zfish   847 IGEDSVHDVFRVSSHIQPNQPMECLSQSVDYNVDEVKALCQSHCSWTDGAESRALHLVHHVQMIS 911

  Fly   593 PC----PYRCSCCFEWHTGEFLINCRNLSLDIYPRLP-------------------------NSI 628
            .|    |...:...:....|.|...:.||..|..|.|                         :.:
Zfish   912 GCQETLPVLSAQELKDSQQEDLTISKVLSFLIRQRRPSRRERHGASAQVIRLLKQWSKLEVRDDV 976

  Fly   629 PYKTTL-YLDRNEIRKLTNTESLVVAGHASIHKL--HMSQNLLRELPLHLLPENITYLDVRNNLL 690
            .|:.|. .|.:.:..:....:||.....:.||.|  |..|    :..:.|..:...:.|:..|:
Zfish   977 LYRVTKDPLTKRKRLQYVLPDSLRNKALSGIHDLAGHQGQ----DRTISLARQRFYWPDMEKNI- 1036

  Fly   691 KYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPED 755
                      .||.:...:..|:.:|   ...|:|.|..::...|||...:.........:|..|
Zfish  1037 ----------REYVQCCRRCVLAKSP---EPAARAPLENIKSTAPMELVCIDFWSAENSKQCSVD 1088

  Fly   756 CICCVDTSNSDSLAYVVDCSGKELSEIPQ-----------LPTPTYGQTTLVFERNSL------- 802
            .:  |.|.:...||:...|:.:...::.:           .|...:......||.|.:
Zfish  1089 VL--VVTDHFTKLAHAFPCANQTAKQVAKKLWDNVFCIYGFPERIHSDQGTNFESNLIAELLRLA 1151

  Fly   803 ---KKWPSSLLP-GYSSVTRFYLAHNR----------LSDIDQLPDKLEYLDISNN 844
               |...::..| |.....||    ||          |.:..|.|.:::.|..:.|
Zfish  1152 GVAKSHTTAYHPMGNGGTERF----NRTLGNLLRSLPLKEKCQWPQQIQTLTFAYN 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/46 (17%)
		leucine-rich repeat	288..308	CDD:275380	8/22 (36%)
		leucine-rich repeat	309..334	CDD:275380	7/27 (26%)
		leucine-rich repeat	335..386	CDD:275380	10/94 (11%)
		leucine-rich repeat	388..408	CDD:275380	4/24 (17%)
		LRR_8	412..465	CDD:290566	10/52 (19%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	8/37 (22%)
		leucine-rich repeat	433..454	CDD:275378	5/20 (25%)
		leucine-rich repeat	455..478	CDD:275378	3/22 (14%)
		leucine-rich repeat	479..490	CDD:275378	4/13 (31%)
		leucine-rich repeat	632..657	CDD:275378	4/25 (16%)
		leucine-rich repeat	658..679	CDD:275378	6/22 (27%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	2/30 (7%)
		leucine-rich repeat	793..815	CDD:275378	6/32 (19%)
		leucine-rich repeat	816..835	CDD:275378	7/28 (25%)
		leucine-rich repeat	836..859	CDD:275378	2/9 (22%)
		TIR	974..1110	CDD:214587
il1rapl1a	XP_021334418.1	retropepsin_like	46..137	CDD:133136
		RT_LTR	403..579	CDD:238825	43/228 (19%)
		RNase_HI_RT_Ty3	701..823	CDD:260006	30/147 (20%)
		rve	1068..1176	CDD:307008	21/113 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910