DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and il1rapl1b

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001136054.1	Gene:	il1rapl1b / 557801	ZFINID:	ZDB-GENE-090109-2	Length:	700	Species:	Danio rerio

Alignment Length:	485	Identity:	106/485 - (21%)
Similarity:	176/485 - (36%)	Gaps:	153/485 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 YETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEI--------PQLP--TPTYGQ 792
            |..|||    ....|.:..:......||..|.|.......|.:|:        |.:.  ||...:
Zfish   116 YSCVLR----NSSYCMKVSMALTVAENSSGLCYNSKMRRLEKAELSKSKDILCPDIQDYTPAGSE 176

  Fly   793 TTLVFERNSL-KKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISN-------NNF--- 846
            ..:.:.:... |:|.||::              |.:|:..:.|..|. ||.|       ..|
Zfish   177 PHVTWYKECRPKQWRSSII--------------RTADLLSIRDVRED-DIGNYTCEIQFGRFLVR 226

  Fly   847 --------SALDDRVRGFLQ---KRMNSSQLQLSLFGNP--WTCRC------------------- 879
                    :.|.|:....||   .:::..:|||   |.|  .|||.
Zfish   227 RTTELTVTAPLTDKPPKILQPPEHKLSVMELQL---GGPVNLTCRAFFGYSGDVSPLIYWMKGEK 288

  Fly   880 --EDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETDI----C----------------PSV 922
              ||.|.....:.:.|.:......|.:....::..::|.|:    |                ...
Zfish   289 FIEDLDETRIRESEIKMVREHLGEQEVSVSLTIDSLQEEDLGNYSCYVENGHGRRHAIIQLSRRE 353

  Fly   923 LIYYTSLA----VSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELD-EDKKYDAFLSFT 982
            |:|...||    ..||::...::::.|:|..:|:::..|      ....::| |:|.|||::|:|
Zfish   354 LMYTVELAGGLGAILLMLIFLVSLYKCYRIELMLFYRNH------FGSEDVDGENKDYDAYVSYT 412

  Fly   983 HKDED------------LIEEFVDRLENGRHKFRLCFYLRDWL-VGESIPD---CINQSVKGSRR 1031
            ..|.|            .:|...|.||. .:.::|....||.: .|..|.|   |::|    |:|
Zfish   413 KVDPDQWSQETREEEHFALEILPDMLEK-HYGYKLFIPDRDLIPTGTYIEDVARCVDQ----SKR 472

  Fly  1032 IIILMTKNF-LKSTWG--RLEFRLALHATSRD------RCKRLIVVL-YPDVEHFDDLDSELRAY 1086
            :||:||.|: ::..|.  .||.||.....|.:      .|..|..:: |.:||       .|:..
Zfish   473 LIIVMTPNYVVRRGWSIFELETRLRNMLVSGEIKVILIECSDLRGIMNYQEVE-------ALKHT 530

  Fly  1087 MVLNTYL-------DRNNPNFWNKLMYSMP 1109
            :.|.|.:       .:.|..||.:|.|.||
Zfish   531 IKLLTVIRWPGPGSSKPNSRFWKQLQYEMP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380	5/29 (17%)
		leucine-rich repeat	793..815	CDD:275378	4/22 (18%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	9/43 (21%)
		TIR	974..1110	CDD:214587	47/169 (28%)
il1rapl1b	NP_001136054.1	PHA02785	7..334	CDD:165149	45/239 (19%)
		Ig	32..135	CDD:299845	5/22 (23%)
		Ig	148..234	CDD:299845	17/100 (17%)
		Ig	263..348	CDD:143165	11/84 (13%)
		TIR	405..559	CDD:279864	45/165 (27%)
		Required for synaptic vesicle accumulation during synaptogenesis	564..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910