DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr11

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001138251.2	Gene:	Tlr11 / 498491	RGDID:	1564460	Length:	932	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	211/1028 - (20%)
Similarity:	364/1028 - (35%)	Gaps:	280/1028 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 YLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGL 277
            :|..|..|....|..:.|...|||.:      ..:....|:..|.|.|...:..|... |....:
  Rat    66 HLLASCSNVKNINQTLEKVPRNTEVL------CLQGMVPTLPANAFDGFYSLQLLRLQ-LGTTNI 123

  Fly   278 TNNTFENLTSLNTLIFD-------NVFL--KDLSFLRSSTLQSSLTYCI---------------- 317
            |:.||:.|..|..|.|:       ::||  ..|..|||.:..|...||:
  Rat   124 TSRTFQGLDQLQYLFFEHHAPCCLSLFLPPDSLESLRSLSSLSFQGYCLTYSHSIYLPTTLRHLT 188

  Fly   318 MKVDNMVDLKSFEK-FTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYN 381
            |:...:..|:..:: |.:| ::..|.....|..|.|:               ||     .:.|||
  Rat   189 MRNSCLTKLQELQRLFPDL-LLGASSTPNTKPRTPFL---------------EV-----LDLSYN 232

  Fly   382 RDKSQLEI-DCWQKNL-------TTIPSLPVPKKGSSALVFQSNL---LAELPDNSLEGYHNLKS 435
            ....|..| |.:...|       |.:.:|.:...|...|.|.|.:   :.:|| .|:.|:..|.:
  Rat   233 LQLKQAGIRDLYGLTLHSLILDGTPLRALDLTSSGLLHLHFLSLVGTGIEKLP-ASVTGFSELCA 296

  Fly   436 LDVSYNQLTSL----SVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEY 496
            ||:..||:.::    .:..| ::|.:|.:..|.:.:|..:.:..|..:...|...||
  Rat   297 LDLGKNQIQNILGNGDILGL-KALKFLSLHDNHLQSLPVRFLRTLPQLQKLNLSMNK-------- 352

  Fly   497 HLQEFFWYKAKLLRIKTSKFQTIMEYIELS-------SKGSFVENFFVQNIDQLYLEANEDEIID 554
                    ...:|.:....|.|.:..::||       .:|:|   .|:..:.:|:|..|
  Rat   353 --------LGPILELPEGLFSTNLTVLDLSHNQLCEIPRGNF---SFLSQLQELWLSGN------ 400

  Fly   555 AFGPSDKYFNLKLM--EALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLS 617
                     |:..:  |:|....||                                    |.|.
  Rat   401 ---------NISSLSNESLQGLRWL------------------------------------RTLD 420

  Fly   618 LD------IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLL 676
            |.      :.|...:.:|..|||.|....:..::.|:.             ....:||.|.|...
  Rat   421 LSWNQIKVLKPGWLSHLPALTTLNLLGTYLEHISGTQL-------------QGPKMLRHLQLGSF 472

  Fly   677 PENITY---------LDVR-NNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLR 731
            |....|         |::: ...::::......|| :.||:| :|.|....|.......|.| ||
  Rat   473 PTLEIYRLWFPMLLSLEIQAETYIQFMVPSGEPFL-FLENLT-LETSNLLLEPKTTTIHFPS-LR 534

  Fly   732 RHEPMEYETVLRRVEITDDKCPE------DCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTY 790
            |.....|...|...::.....|:      ..:.|   .|.|:    ||.   .|.|:|:|.....
  Rat   535 RLTLRGYSIFLSTSQLQSFFPPQLPLLEYFFVWC---RNDDA----VDL---HLFEMPRLRVLEL 589

  Fly   791 GQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISN---NNFSALDDR 852
            |.....:|               ||..:..:..|.:..:..|  .|.:|::.|   ::|..|..
  Rat   590 GNLNFFYE---------------SSTVKLEMLLNEVPQLQVL--ALSHLNLKNLSVSSFKGLQS- 636

  Fly   853 VRGFLQKRMNSSQLQLSLFGN-----------------PWTCRCEDK----------DFLVFVKE 890
                |:..:.:|:..|.:..|                 .:.|:||..          :..|:..|
  Rat   637 ----LKLLLLNSERALEMNSNLQELIPQIPQYVYFSDVTFACQCETSWLESWATRAPNTFVYGLE 697

  Fly   891 QAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSL-AVSLLIIALSINVFICFRQPIM--I 952
            :...:||||     |..::|:.......||....::..| :.|||::.:.:.:..|.:...:  :
  Rat   698 KPICMANAS-----DYSKTLLFSFLATNCPHGTEFWGFLTSFSLLLLLIILPLISCHKWSWLHHL 757

  Fly   953 WFYEHEICLSLAARRELDEDKKYDAFLSFTHKDED-LIEEFVDRLENGRHK---FRLCFYLRDWL 1013
            |...|.....|...| |.....||.|:|:..:|:| ::||.|..||....:   .|||...||:.
  Rat   758 WTLFHTCWWKLGGHR-LRGQFNYDVFISYCEEDQDWVLEELVPVLEKAPPEGEGLRLCLPARDFG 821

  Fly  1014 VGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLA-LHATSRDRCKRLIVVLYPDVEHFD 1077
            :|....:.:..|:..||.|:.::|...|.|.|..||.||| .|..:|.....|:::.      .:
  Rat   822 IGNDRMESMIASMGKSRAILCVLTGQALASPWCNLELRLATYHLIARPGTTCLLLLF------LE 880

  Fly  1078 DLD-SELRAYMVLNTYLDRNN-------PNFWNKLMYSMPHASHLKRSRSDAE 1122
            .|| .:|.:|..|:.:|.:.:       ...||.....:  ...|:::|.:.|
  Rat   881 PLDRQKLHSYHRLSRWLQKEDYFDLSQGKMEWNTFCEQL--KQRLRKARKERE 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..308	CDD:275380	9/28 (32%)
		leucine-rich repeat	309..334	CDD:275380	6/41 (15%)
		leucine-rich repeat	335..386	CDD:275380	10/50 (20%)
		leucine-rich repeat	388..408	CDD:275380	5/27 (19%)
		LRR_8	412..465	CDD:290566	16/59 (27%)
		leucine-rich repeat	412..432	CDD:275378	7/22 (32%)
		LRR_4	432..470	CDD:289563	10/41 (24%)
		leucine-rich repeat	433..454	CDD:275378	6/24 (25%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	5/24 (21%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	4/35 (11%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	6/19 (32%)
		leucine-rich repeat	793..815	CDD:275378	1/21 (5%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	6/25 (24%)
		TIR	974..1110	CDD:214587	41/148 (28%)
Tlr11	NP_001138251.2	leucine-rich repeat	111..133	CDD:275380	6/22 (27%)
		LRR_RI	<179..427	CDD:238064	60/340 (18%)
		leucine-rich repeat	224..246	CDD:275380	8/41 (20%)
		leucine-rich repeat	248..270	CDD:275380	4/21 (19%)
		LRR_8	270..329	CDD:290566	16/60 (27%)
		leucine-rich repeat	271..293	CDD:275380	7/22 (32%)
		leucine-rich repeat	294..318	CDD:275380	6/24 (25%)
		LRR_8	319..378	CDD:290566	13/74 (18%)
		leucine-rich repeat	319..342	CDD:275380	5/22 (23%)
		leucine-rich repeat	343..367	CDD:275380	5/39 (13%)
		LRR_8	366..426	CDD:290566	17/113 (15%)
		leucine-rich repeat	368..391	CDD:275380	5/25 (20%)
		leucine-rich repeat	392..415	CDD:275380	6/37 (16%)
		LRR_8	416..471	CDD:290566	15/103 (15%)
		leucine-rich repeat	416..437	CDD:275380	5/56 (9%)
		leucine-rich repeat	440..463	CDD:275380	5/35 (14%)
		leucine-rich repeat	533..583	CDD:275380	13/59 (22%)
		leucine-rich repeat	584..612	CDD:275380	6/42 (14%)
		leucine-rich repeat	613..633	CDD:275380	5/21 (24%)
		TIR_2	781..>861	CDD:290400	26/79 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920