DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and kek6

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	88/509 - (17%)
Similarity:	170/509 - (33%)	Gaps:	197/509 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 CPYRCSCCFEWHTGEFLINCRNLSLDIYPRL-----------PNSIPYKT-------------TL 634
            |...|:|  :|..|:....|.:|.|...|..           .|.|||..             .:
  Fly    38 CASNCTC--KWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRI 100

  Fly   635 YLDRNEIR---------------------KLTNTESLVVAGHASIHKLHMSQNLLREL------- 671
            ||.::|::                     ||...:.....|:..:..|:::.|.|:.|
  Fly   101 YLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPI 165

  Fly   672 ------------------PLHLLPEN-ITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPW 717
                              |:.|...| :.:|:::||||:.|.:.|   .::..|:..:.|..|||
  Fly   166 LPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYV---FQHMANLKTLSLEENPW 227

  Fly   718 ECNCKAKAF-----------LSFLRRHEPMEYETVLRRVEITDDK---CP-------EDCICCVD 761
            :||||.:.|           :|.:.:..|.:.:   |..:..||:   ||       .:.:..:|
  Fly   228 QCNCKLRKFRGWYVNSRLSSVSLVCKGPPAQKD---RTWDSVDDELFGCPPRVEIFNNEEVQNID 289

  Fly   762 TSNSDSLAYVVDCSGKELSEIP-QLPTPTYGQTTLVFERNSL---KKWPSSLLPGYSSVTRFYLA 822
            ..::.:.:.:|  .|..|.|:. :|.........::||..|:   |.|        |::|.|
  Fly   290 IGSNTTFSCLV--YGDPLPEVAWELNGKILDNDNVLFESESIASDKLW--------SNLTVF--- 341

  Fly   823 HNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVF 887
                 ::..| |...|....:|:..::...:.                               ::
  Fly   342 -----NVTSL-DAGTYACTGSNSIGSMTQNIS-------------------------------IY 369

  Fly   888 VKEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSL-----LIIALSINVFICFR 947
            :.|..:::              |.:..||       .:|..|.:.:     |:|::|..|.:|.|
  Fly   370 LSEIVQHV--------------LEKTPET-------FWYFGLIMGIFGTVFLLISISFVVCLCKR 413

  Fly   948 QPIMIWFYEHEICLSLAARRELDEDKK-YDAFLSFTHKDEDLIEEFVDRLENGR 1000
                            ..|:....:|. ..:.:||..:::.|::..|....|.|
  Fly   414 ----------------TTRQHRHANKAGVKSSVSFNDQEKKLLDSSVTTTTNDR 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	6/58 (10%)
		leucine-rich repeat	658..679	CDD:275378	6/45 (13%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380	5/20 (25%)
		leucine-rich repeat	793..815	CDD:275378	5/24 (21%)
		leucine-rich repeat	816..835	CDD:275378	3/18 (17%)
		leucine-rich repeat	836..859	CDD:275378	2/22 (9%)
		TIR	974..1110	CDD:214587	6/28 (21%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	4/24 (17%)
		LRR_8	96..155	CDD:290566	8/58 (14%)
		leucine-rich repeat	97..120	CDD:275380	3/22 (14%)
		leucine-rich repeat	121..144	CDD:275380	3/22 (14%)
		LRR_4	144..186	CDD:289563	5/41 (12%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		leucine-rich repeat	169..216	CDD:275380	10/49 (20%)
		LRRCT	225..274	CDD:214507	13/51 (25%)
		Ig	295..367	CDD:143165	17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930