DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tl

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	1129	Identity:	299/1129 - (26%)
Similarity:	483/1129 - (42%)	Gaps:	245/1129 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PG-EMRMGDINCS----NGL---GNIREDYCEIYLDELGENGTCSIANNEVTTEDYQMKLVFLKL 127
            || |...|...||    :||   ..|..:| ||......||.|..:.   :..:||      :::
  Fly    23 PGSEASFGRDACSEMSIDGLCQCAPIMSEY-EIICPANAENPTFRLT---IQPKDY------VQI 77

  Fly   128 EINWTSPVFHGWNIFKICNETDYELVIISV-LGIRSEVDMR------ISPAVQYLSLLGIREISG 185
            ..|.|             :.|||:.:...: :|....|.||      .:|....|..|||  :|
  Fly    78 MCNLT-------------DTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGI--VS- 126

  Fly   186 YDIYLPSVLITEMD----------VHHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKI 240
                 |:.||.|.|          :...:|.|...|           .|........|....::.
  Fly   127 -----PTTLIFESDNLGMNITRQHLDRLHGLKRFRF-----------TTRRLTHIPANLLTDMRN 175

  Fly   241 YYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLR 305
            ..|.........|..::|.....:.::.|...|::.:....|..:..|..|   |::...|..|.
  Fly   176 LSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQL---NLWSNQLHNLT 237

  Fly   306 SSTLQSSLTYCIMKV-DNMVDLKSFEKF---TNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLG 366
            ....:.:.:...:.: ||.::....:.|   ||:..|.:|     .|....:.:....|.|.
  Fly   238 KHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLS-----ANLFRSLPQGLFDHNKH--- 294

  Fly   367 INEVACPLKCNCSYNR------------DKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNL 418
            :|||      ....||            ::.:|:|...:..|.::| .|.......:.:....||
  Fly   295 LNEV------RLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNL 353

  Fly   419 LAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIR--HNKITTLSPQVVEYLYSVNV 481
            |..||...||...||.|||:|.|:||.|..|....:.:..|:|  .|.:|.:|.         ::
  Fly   354 LKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISG---------DI 409

  Fly   482 FNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLE 546
            |:..||                  ...|.:..::.:||.....:|:.|          :..|:|:
  Fly   410 FSNLGN------------------LVTLVMSRNRLRTIDSRAFVSTNG----------LRHLHLD 446

  Fly   547 ANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLI 611
            .|:               :.|.:.|          .|.::...:|||        |.:..|...:
  Fly   447 HND---------------IDLQQPL----------LDIMLQTQINSP--------FGYMHGLLTL 478

  Fly   612 NCRNLS-LDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL 675
            |.||.| :.:|....|::.....|.|..|.|..| ..|.|.......:| ::|:.|.:|.:   .
  Fly   479 NLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSL-GYEDLAFLSQNRLH-VNMTHNKIRRI---A 538

  Fly   676 LPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRR-HEP---- 735
            |||::           :|.:|      |..|:..::|:.||..|:|....|:..:|. |:|
  Fly   539 LPEDV-----------HLGEG------YNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSR 586

  Fly   736 ------------------------MEYETVLRRVEITDD----KCPEDCICCVDTSNSDSLAYVV 772
                                    :|.:|::..::.:||    |||..|.|.|.|.:.   |.|:
  Fly   587 QFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDK---ALVI 648

  Fly   773 DCSGKELSEIPQLPT--PTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLS--DIDQLP 833
            :|....|:.:|:||.  .......|..|.|:|.:.||:..|||.|||..:||.|.|:  |:||||
  Fly   649 NCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLP 713

  Fly   834 DKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANA 898
            ..|.:||||.|:...|:..|.|||.:.|....::||  ||||.|.|..|..|:|.::..:.|.:.
  Fly   714 TNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLS--GNPWMCDCTAKPLLLFTQDNFERIGDR 776

  Fly   899 SAIQCI--DTGRSLIEVEETDICPSVLIYYTSLAVSL----LIIALSINVFICFRQPIMIWFYEH 957
            :.:.|:  :....::|:...||||:....:.:|||.:    |:...:..::..|:..|.||.|.|
  Fly   777 NEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAH 841

  Fly   958 EICLSLAARRELDEDKKYDAFLSFTHKDEDLIEEF-VDRLENGRHKFRLCFYLRDWLVGESIPDC 1021
            .:.|......:||:|||:|||:|::|||:..||:: |.:||:|..||:||.:.||||||..||:.
  Fly   842 NLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPEN 906

  Fly  1022 INQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAY 1086
            |.:||..|||.||::::||:||.|.|||||.|..:...:...|:||::|.|:...:.||.||:||
  Fly   907 IMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAY 971

  Fly  1087 MVLNTYLDRNNPNFWNKLMYSMPH 1110
            :.:||||...:|.||:||.:::||
  Fly   972 LKMNTYLKWGDPWFWDKLRFALPH 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	3/22 (14%)
		leucine-rich repeat	288..308	CDD:275380	5/19 (26%)
		leucine-rich repeat	309..334	CDD:275380	3/28 (11%)
		leucine-rich repeat	335..386	CDD:275380	10/62 (16%)
		leucine-rich repeat	388..408	CDD:275380	4/20 (20%)
		LRR_8	412..465	CDD:290566	21/54 (39%)
		leucine-rich repeat	412..432	CDD:275378	7/19 (37%)
		LRR_4	432..470	CDD:289563	15/39 (38%)
		leucine-rich repeat	433..454	CDD:275378	10/20 (50%)
		leucine-rich repeat	455..478	CDD:275378	5/24 (21%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	7/24 (29%)
		leucine-rich repeat	658..679	CDD:275378	6/20 (30%)
		leucine-rich repeat	680..706	CDD:275378	3/25 (12%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	6/21 (29%)
		leucine-rich repeat	793..815	CDD:275378	9/21 (43%)
		leucine-rich repeat	816..835	CDD:275378	11/20 (55%)
		leucine-rich repeat	836..859	CDD:275378	11/22 (50%)
		TIR	974..1110	CDD:214587	65/136 (48%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	9/61 (15%)
		leucine-rich repeat	176..198	CDD:275380	3/21 (14%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	87/417 (21%)
		LRR_8	221..281	CDD:290566	13/67 (19%)
		leucine-rich repeat	223..270	CDD:275380	8/49 (16%)
		leucine-rich repeat	271..294	CDD:275380	4/27 (15%)
		leucine-rich repeat	295..320	CDD:275380	5/30 (17%)
		leucine-rich repeat	321..343	CDD:275380	5/21 (24%)
		LRR_8	342..402	CDD:290566	21/59 (36%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		leucine-rich repeat	368..391	CDD:275380	10/22 (45%)
		LRR_8	390..450	CDD:290566	16/111 (14%)
		leucine-rich repeat	392..415	CDD:275380	6/31 (19%)
		leucine-rich repeat	416..439	CDD:275380	4/22 (18%)
		leucine-rich repeat	440..474	CDD:275380	10/66 (15%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		LRR_8	477..534	CDD:290566	16/58 (28%)
		leucine-rich repeat	499..520	CDD:275380	7/21 (33%)
		leucine-rich repeat	523..552	CDD:275380	10/49 (20%)
		LRRCT	561..619	CDD:214507	10/57 (18%)
		LRRNT	631..667	CDD:214470	13/38 (34%)
		leucine-rich repeat	664..693	CDD:275380	9/28 (32%)
		LRR_8	669..726	CDD:290566	27/56 (48%)
		leucine-rich repeat	694..715	CDD:275380	11/20 (55%)
		leucine-rich repeat	716..737	CDD:275380	9/20 (45%)
		LRRCT	751..800	CDD:214507	13/48 (27%)
		TIR	858..996	CDD:214587	67/138 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453758
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I3869
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	9	8.900