DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and 2mit

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	122/589 - (20%)
Similarity:	185/589 - (31%)	Gaps:	251/589 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 RDKSQLEIDC-------WQKNLTTIPSLPVPKKGS----SALVFQSNLLAELPDNSLEGYHNLKS 435
            |.|.:||::.       ..::|.|..|.....||.    :|:...||.|..|   ||:.::.|:.
  Fly    85 RHKRELELNAPANKLNLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLESL---SLDNFNQLRQ 146

  Fly   436 LDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQE 500
            ||:..|     |:..:|.||        ..|.:|...|....|.|.|:|
  Fly   147 LDLGNN-----SLEVIPLSL--------ADTNMSLPFVTLDLSCNKFSQ---------------- 182

  Fly   501 FFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNL 565
                      |.||                    ||.|.:.||                 |..||
  Fly   183 ----------ISTS--------------------FFAQRLPQL-----------------KNLNL 200

  Fly   566 KLMEALNHAIWLFSG--EFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSI 628
            ...|.||.:...|..  |...::|.|                        .|:|         .|
  Fly   201 AHNELLNISRESFYNLLELQTLVLSH------------------------NNIS---------DI 232

  Fly   629 PYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYL 693
            .|:|.|.|                                         .|:.|||:.:|   .|
  Fly   233 DYETFLAL-----------------------------------------PNLQYLDLSHN---RL 253

  Fly   694 DDGVIAFLEYRENITKIELSGNP------------WECN---------CKAKAFLSFLRRHEPME 737
            ....|..|:...::..:.::.||            |...         |:..|.|:
  Fly   254 SGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALA--------- 309

  Fly   738 YETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQ----TTLVFE 798
              ..:|.::::|:..  ..|.|.|..:...|.| :|.|.   |.|.|:.....|:    .:|..:
  Fly   310 --QSVRTLKLSDNWL--KAINCGDMDSYPLLQY-LDLSH---SRIAQVEDDALGRLELLESLFLD 366

  Fly   799 RNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDK-------LEYLDISNNNFSALDD-RVRG 855
            ||.|.:.||||.|   |:...:|.||:   |.:||.:       |:.||:|||....|.. .:..
  Fly   367 RNLLMRVPSSLPP---SLEHLFLQHNQ---IMELPPQAFVGLVNLQTLDLSNNRLIFLPPLSLPK 425

  Fly   856 FLQKRMNSSQLQ---------------LSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCID 905
            .|...:.||.::               |.|..||  .:|.|   |:.:.|.      ||..:.:|
  Fly   426 LLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNP--IKCSD---LLGIAEW------ASPCRSVD 479

  Fly   906 TGRS 909
            .|:|
  Fly   480 AGQS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	2/3 (67%)
		leucine-rich repeat	388..408	CDD:275380	4/26 (15%)
		LRR_8	412..465	CDD:290566	14/52 (27%)
		leucine-rich repeat	412..432	CDD:275378	6/19 (32%)
		LRR_4	432..470	CDD:289563	9/37 (24%)
		leucine-rich repeat	433..454	CDD:275378	6/20 (30%)
		leucine-rich repeat	455..478	CDD:275378	4/22 (18%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	3/24 (13%)
		leucine-rich repeat	658..679	CDD:275378	0/20 (0%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	3/23 (13%)
		leucine-rich repeat	771..791	CDD:275380	5/19 (26%)
		leucine-rich repeat	793..815	CDD:275378	9/21 (43%)
		leucine-rich repeat	816..835	CDD:275378	6/18 (33%)
		leucine-rich repeat	836..859	CDD:275378	8/23 (35%)
		TIR	974..1110	CDD:214587
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	73/403 (18%)
		leucine-rich repeat	124..143	CDD:275380	7/21 (33%)
		leucine-rich repeat	144..167	CDD:275380	9/35 (26%)
		leucine-rich repeat	172..194	CDD:275380	10/67 (15%)
		LRR_8	193..253	CDD:290566	24/153 (16%)
		leucine-rich repeat	195..218	CDD:275380	8/39 (21%)
		leucine-rich repeat	219..242	CDD:275380	9/96 (9%)
		LRR_8	241..301	CDD:290566	11/62 (18%)
		leucine-rich repeat	243..311	CDD:275380	13/81 (16%)
		leucine-rich repeat	312..335	CDD:275380	5/24 (21%)
		LRR_8	334..415	CDD:290566	30/90 (33%)
		leucine-rich repeat	336..359	CDD:275380	8/26 (31%)
		leucine-rich repeat	360..380	CDD:275380	9/22 (41%)
		LRR_8	379..460	CDD:290566	22/88 (25%)
		LRR_4	379..>415	CDD:289563	14/41 (34%)
		leucine-rich repeat	381..404	CDD:275380	6/25 (24%)
		leucine-rich repeat	405..449	CDD:275380	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930