DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and CG7800

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_649770.1 Gene:CG7800 / 40963 FlyBaseID:FBgn0037552 Length:533 Species:Drosophila melanogaster


Alignment Length:588 Identity:116/588 - (19%)
Similarity:198/588 - (33%) Gaps:200/588 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 EDYC-EIYLDELGENGTCSIANNEVTTE---DYQMKLVFLKLEINWTSPVFHGWNIFKICNETDY 150
            |||| :.|...||.:.|.|.......||   |...|.| |||..|..:.....      |:..|:
  Fly    21 EDYCNDSYCHLLGRSRTFSDKKATKLTEFHMDSCEKKV-LKLMPNLRTLELEN------CDSPDF 78

  Fly   151 ELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKM------- 208
            .:..::.|...:.:.:|..      :|||:.                 |.|.:..|.|       
  Fly    79 TMNDLNQLPYLTSLQLRRG------NLLGLH-----------------DEHFSKWPNMKILMLGG 120

  Fly   209 --VT------FKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYH-----NTFEKTTLTMEKNIFHG 260
              :|      ||.|....:.|:..|.......:..:.:....|     |..|    |:.:|||.|
  Fly   121 NNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIE----TLHENIFTG 181

  Fly   261 KNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVF-LKDLSFLRSSTLQSSLTYCIMKVDNMV 324
            ..|:..|:.||..:..:...:.::|::|..|...|.. |.|||...:.||             ::
  Fly   182 VPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSNCGPLPDLSLPGAHTL-------------IL 233

  Fly   325 DLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQ-LE 388
            |....::...|..:...|.:             |:|      |.|:..|         |||. :|
  Fly   234 DNSGVQRLDILGSVHKLQAR-------------KNH------ITEIKLP---------DKSSVIE 270

  Fly   389 IDCWQKNLTTIPSLPVPKKGS---SALVFQSNLL----AELPDNSLEGY--HNLKSLDVSYNQLT 444
            :|. ..||.|...:|....|.   ..|....|::    |...||:.|.:  .||..:::|.|:||
  Fly   271 LDL-HSNLLTATDIPKLLTGMWRLQRLDLSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLT 334

  Fly   445 SLSV-SQLP-ESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGN--------KW---------S 490
            .|.. |.:| |.|.:||..:|:|...:...::..:::...:..||        .|         :
  Fly   335 RLHFDSPIPWERLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVA 399

  Fly   491 IYCDEY------HLQEFF----------------------------------------------- 502
            :|.:::      ::.:||                                               
  Fly   400 LYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPTCKPCIPDARDFPTSISADTNQTIDT 464

  Fly   503 --------------WYKAKLLRIKTSKFQT---IMEYIELSSKGSFVENFFVQNIDQLYLEANED 550
                          |....|:.:..|.|..   |::.|.|..:..|.::..|..|.:::...::|
  Fly   465 KVNPLSNDTYQWNVWNVLMLVSLIVSLFVNSFLIVKLIRLRGRNQFTQSSSVPAIIEMFSNESDD 529

  Fly   551 EII 553
            |||
  Fly   530 EII 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..308 CDD:275380 7/20 (35%)
leucine-rich repeat 309..334 CDD:275380 2/24 (8%)
leucine-rich repeat 335..386 CDD:275380 9/50 (18%)
leucine-rich repeat 388..408 CDD:275380 6/19 (32%)
LRR_8 412..465 CDD:290566 20/60 (33%)
leucine-rich repeat 412..432 CDD:275378 6/25 (24%)
LRR_4 432..470 CDD:289563 15/39 (38%)
leucine-rich repeat 433..454 CDD:275378 8/22 (36%)
leucine-rich repeat 455..478 CDD:275378 5/22 (23%)
leucine-rich repeat 479..490 CDD:275378 3/27 (11%)
leucine-rich repeat 632..657 CDD:275378
leucine-rich repeat 658..679 CDD:275378
leucine-rich repeat 680..706 CDD:275378
leucine-rich repeat 707..719 CDD:275378
leucine-rich repeat 771..791 CDD:275380
leucine-rich repeat 793..815 CDD:275378
leucine-rich repeat 816..835 CDD:275378
leucine-rich repeat 836..859 CDD:275378
TIR 974..1110 CDD:214587
CG7800NP_649770.1 leucine-rich repeat 46..64 CDD:275380 8/18 (44%)
leucine-rich repeat 65..85 CDD:275380 2/25 (8%)
LRR_8 87..147 CDD:290566 14/82 (17%)
leucine-rich repeat 89..112 CDD:275380 6/45 (13%)
leucine-rich repeat 113..136 CDD:275380 5/22 (23%)
LRR_RI <131..334 CDD:238064 55/248 (22%)
leucine-rich repeat 137..160 CDD:275380 2/22 (9%)
LRR_8 140..195 CDD:290566 14/58 (24%)
leucine-rich repeat 161..184 CDD:275380 8/26 (31%)
leucine-rich repeat 185..208 CDD:275380 4/22 (18%)
leucine-rich repeat 209..246 CDD:275380 11/49 (22%)
leucine-rich repeat 247..267 CDD:275380 8/47 (17%)
leucine-rich repeat 268..292 CDD:275380 7/24 (29%)
leucine-rich repeat 293..322 CDD:275380 6/28 (21%)
leucine-rich repeat 395..406 CDD:275378 1/10 (10%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453778
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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