DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr20f

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_009303059.3	Gene:	tlr20f / 403141	ZFINID:	ZDB-GENE-040220-7	Length:	956	Species:	Danio rerio

Alignment Length:	1065	Identity:	218/1065 - (20%)
Similarity:	384/1065 - (36%)	Gaps:	319/1065 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 MNNTEKIKI----YYHNTFEKTTLTME----KNIFHGKNKMSALIFNGLKIKGLTN-NTFENLTS 287
            |.|||::|:    .:...|.||:..:.    |.:|:.            .::|.|: :|:...|:
Zfish     9 MKNTEELKMGLLFAFFMLFLKTSYVLSWIPGKCVFYS------------DMEGFTSASTYAGQTN 61

  Fly   288 LNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVD----NMVDLKSFEKFTNLEIIEVS------- 341
            :...:......:||..|.::.|.     ..:|:|    .::...||.... ||.:|::
Zfish    62 IAKCVSVTDIKEDLRGLPANVLN-----LYIKMDLHSHGVLSPNSFSNLAXLEYLEITGCFSEIP 121

  Fly   342 --QYKGFKNFTAFICEPYKSH--CKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQK--NLTTIP 400
              .:.|..:.|:.....:.|.  |:..|..:.:......:.|| ...|.||.:.::|  .|..:.
Zfish   122 PKAFSGLPHLTSLTISSFSSENWCEVALDFSHLPSLTSLSISY-YSLSLLEPNVFEKIPQLQNLY 185

  Fly   401 SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKI 465
            .:.|..|..|.::.:           |.....||..::..:.||.|   |.|....:      .|
Zfish   186 LIDVRLKNMSEILCR-----------LTNIKKLKQFNLFDDALTHL---QKPNCSVF------NI 230

  Fly   466 TTLSPQV-VEY--LYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSS 527
            :.:|.:. :||  ||..||         .:.||..|:.|    .||..|........:.|:.|..
Zfish   231 SDISTEFNIEYADLYLNNV---------EHVDEGALKVF----GKLFCINFGSNTDFLRYLSLIG 282

  Fly   528 KGSFVENFFVQNIDQLYLEANEDEIIDAFGPSD-------------------------------- 560
                     |..|..||::      :|....:|
Zfish   283 ---------VHKISSLYVD------VDVLNVNDLCTAAKLYSIESIFADYKTINLPQTQTNISEG 332

  Fly   561 ----------KYFNLKLMEALNHAIWLFSGEFD-EIILHHLNSPCPYRCSCCFEWHTGEFLINCR 614
                      |:||..::: :|..:.|||.... :|.||...|. .::..|..:.|.      .:
Zfish   333 CRKIKNIVLNKHFNANILD-VNSVVQLFSNLTSIKIFLHMFRSD-DFQSLCASKPHA------VK 389

  Fly   615 NLS-LDIYPRLPNSIPYKTT-------LYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLREL 671
            .:| :.:.|.:...:.::.|       |.|..|:|   .|.|.....|...:.:|::|.|.|..:
Zfish   390 QISVMSLGPYIDFIVSFQFTCFTNLIILELFNNQI---YNIEDFAFVGLNKLEELYLSGNKLSYI 451

  Fly   672 PLHLLP--ENITYLDVRNNLLKYLDDG-----------VIAFLEYRENIT--KIELS----GNPW 717
            ..|...  ..:..||::.|.:.|::..           ::..|.:..:::  |:.||    |.|
Zfish   452 HQHTFSGLHELMVLDLQGNHIIYIEPKSFGHFMNITTLLLGDLNFSPDMSLIKVNLSDIFYGIP- 515

  Fly   718 ECNCKAKAFLSFLR-RHEPMEYETVLR---RVEITDDKCPEDCICCVDTSNSDSLAYVV--DCSG 776
             ||.......|.|| .|..|...|.|.   .:.||..                   ||:  ||:.
Zfish   516 -CNLSNLFLSSGLRPMHLVMGSNTTLNNGLNLRITGQ-------------------YVIVEDCNN 560

  Fly   777 KELSEIPQLPTPTYGQTTLVF---ERNSLKKWPSSLLPGYSSVTRFYLAHNRLSD-------IDQ 831
            ..|:.:..|      |....:   |...:.|:    :|...|:.    .|::.||       |:|
Zfish   561 LLLTSVVSL------QINAAYVSCENEFIGKY----VPSVVSLE----FHSKFSDNIGDLAVINQ 611

  Fly   832 LPD----KLEYLDISN--------NNFSALDDRV---------RGFLQKRMNS------------ 863
            |..    |||.:|..|        :|.:.|...:         .|.|.|.:.:
Zfish   612 LVHLKTLKLEDIDFKNQPNLAIMFHNLTKLQTLILANCRIFFLDGSLTKDLTALRKLILIPTNTV 676

  Fly   864 ----------SQLQLSLF-GNPWTCRCEDKDFLVFVKEQAK---NIANASA--IQCIDTGRSLIE 912
                      :.|:...| |....|.|:|...:.:||:..|   ::.|.:.  :||:...    |
Zfish   677 NILQTFVEHLTDLEYVYFEGLGLYCSCDDAWLVSWVKDNRKVEVSMFNPTMQDLQCLIEN----E 737

  Fly   913 VEETDICPSV---------LIYYTSLAVSLLIIALSI-------NVFICFRQPIMIWFYEHEICL 961
            |::.:....|         .:::.|.||.|.|..:.:       ..|..|......||.|
Zfish   738 VDQLNFVSFVKENCSFDIEFVFFASTAVFLCIFIVVVLMYKFVGQYFKPFFHIASGWFRE----- 797

  Fly   962 SLAARRELDEDKKYDAFLSFTHKDED-LIEEFVDRLE-NGRHKFRLCFYLRDWLVGESIPDCINQ 1024
              ..|.:..:..:||.|:|::.|||. ::||.:..|| .|....|:|.:.||:.:|..|.:.|..
Zfish   798 --VLRMKKKQQYRYDVFVSYSSKDEHWVMEELLPNLEQRGPPFLRICLHSRDFQLGHDIVENITD 860

  Fly  1025 SVKGSRRIIILMTKNFLKSTWGRLEFRLA---LHATSRDRCKRLIVVLYPDVEHFDDLDSELRAY 1086
            |:..|||.:.|:::|:|.|.|..||.:||   |....||    ::::::.:......|.|..|..
Zfish   861 SIYASRRTLCLVSQNYLGSNWCSLEMQLATYRLQVEHRD----ILILVFLETIPSRLLSSHHRLA 921

  Fly  1087 MVL--NTYLD-----RNNPNFWNKL 1104
            .::  .||||     ..:..||::|
Zfish   922 RLVKTRTYLDWPHDPERHEAFWHRL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	3/23 (13%)
		leucine-rich repeat	288..308	CDD:275380	3/19 (16%)
		leucine-rich repeat	309..334	CDD:275380	5/28 (18%)
		leucine-rich repeat	335..386	CDD:275380	10/61 (16%)
		leucine-rich repeat	388..408	CDD:275380	4/21 (19%)
		LRR_8	412..465	CDD:290566	8/52 (15%)
		leucine-rich repeat	412..432	CDD:275378	1/19 (5%)
		LRR_4	432..470	CDD:289563	8/37 (22%)
		leucine-rich repeat	433..454	CDD:275378	7/20 (35%)
		leucine-rich repeat	455..478	CDD:275378	5/25 (20%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	8/31 (26%)
		leucine-rich repeat	658..679	CDD:275378	5/22 (23%)
		leucine-rich repeat	680..706	CDD:275378	5/36 (14%)
		leucine-rich repeat	707..719	CDD:275378	5/17 (29%)
		leucine-rich repeat	771..791	CDD:275380	5/21 (24%)
		leucine-rich repeat	793..815	CDD:275378	3/24 (13%)
		leucine-rich repeat	816..835	CDD:275378	6/29 (21%)
		leucine-rich repeat	836..859	CDD:275378	8/39 (21%)
		TIR	974..1110	CDD:214587	45/143 (31%)
tlr20f	XP_009303059.3	LRR_8	<96..138	CDD:316378	7/41 (17%)
		leucine-rich repeat	108..130	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..180	CDD:275380	10/49 (20%)
		leucine-rich repeat	181..206	CDD:275380	5/35 (14%)
		leucine-rich repeat	207..238	CDD:275380	9/39 (23%)
		leucine-rich repeat	239..262	CDD:275380	10/35 (29%)
		leucine-rich repeat	263..324	CDD:275380	10/75 (13%)
		leucine-rich repeat	325..380	CDD:275380	11/56 (20%)
		LRR_8	412..472	CDD:316378	15/62 (24%)
		leucine-rich repeat	414..437	CDD:275378	7/25 (28%)
		leucine-rich repeat	438..461	CDD:275378	5/22 (23%)
		leucine-rich repeat	462..485	CDD:275378	4/22 (18%)
		leucine-rich repeat	486..497	CDD:275378	1/10 (10%)
		leucine-rich repeat	521..589	CDD:275380	18/96 (19%)
		leucine-rich repeat	590..614	CDD:275380	7/27 (26%)
		leucine-rich repeat	615..640	CDD:275380	6/24 (25%)
		leucine-rich repeat	641..664	CDD:275380	4/22 (18%)
		TIR	808..946	CDD:214587	44/141 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010