DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr5b

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001124067.2	Gene:	tlr5b / 403139	ZFINID:	ZDB-GENE-040219-15	Length:	881	Species:	Danio rerio

Alignment Length:	1033	Identity:	213/1033 - (20%)
Similarity:	373/1033 - (36%)	Gaps:	316/1033 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 CNETDYELVIISVLGIRSEVDMRISPA-VQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKM 208
            |:...|..:.|: .|:....::   || |.|:           |:.|.|  |.|::....:..:.
Zfish    31 CSVIGYNAICIN-RGLHQVPEL---PAHVNYV-----------DLSLNS--IAELNETSFSRLQD 78

  Fly   209 VTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLK 273
            :.|..:...|...||.||..| .:::...:|:.| |.|    |.:|...|:|...:..|......
Zfish    79 LQFLKVEQQTPGLVIRNNTFR-GLSSLIILKLDY-NQF----LQLETGAFNGLANLEVLTLTQCN 137

  Fly   274 IKG--LTNNTFENLTSLNTLIF-DNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNL 335
            :.|  |:.|.|:.||||..|:. ||...|         :|.:..:..|:..:::|| :|.|..::
Zfish   138 LDGAVLSGNFFKPLTSLEMLVLRDNNIKK---------IQPASFFLNMRRFHVLDL-TFNKVKSI 192

  Fly   336 EIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQK-----N 395
            ...::..::| |:||.                      |:.:....:|.::..:. |:|     .
Zfish   193 CEEDLLNFQG-KHFTL----------------------LRLSSITLQDMNEYWLG-WEKCGNPFK 233

  Fly   396 LTTIPSLPVPKKG---SSALVF---------QSNLLAEL--------------PDN----SLEGY 430
            .|:|.:|.:...|   |.|..|         ||.:|:..              |||    .||.
Zfish   234 NTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEA- 297

  Fly   431 HNLKSLDVSYNQLTSL--SVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYC 493
            ..:|:.|:|.:::.:|  ||......|..|.:..|:|..:....
Zfish   298 SGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNA--------------------- 341

  Fly   494 DEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGP 558
                    ||....||::..|:          :..||.....| :|:|:|       |::|.
Zfish   342 --------FWGLTHLLKLNLSQ----------NFLGSIDSRMF-ENLDKL-------EVLDL--- 377

  Fly   559 SDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPR 623
                       :.||                                       .|.|....:..
Zfish   378 -----------SYNH---------------------------------------IRALGDQSFLG 392

  Fly   624 LPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHA-----SIHKLHMSQNLLREL-PLHLLPENITY 682
            |||              :|||..|.:.|.:.|.     :::||::.:|.:..: .|..:..|::.
Zfish   393 LPN--------------LRKLNLTGNAVESVHTFAALPNLNKLYLGKNRISSVSSLPNIAHNLST 443

  Fly   683 LDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEI 747
            ||:..|.|..|.|......|:.: |..|.|.||.:. :|..:..:....:.:.:.......::..
Zfish   444 LDLEFNKLHALSDLYTILREFPQ-IENIFLQGNTFS-SCYNQKQIVLSDKLQLLHLGLSSMQLIW 506

  Fly   748 TDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPG 812
            ::.||               |....|     |.::.||.          ...|.|:..|..:...
Zfish   507 SEGKC---------------LNVFAD-----LHQLQQLS----------LTANGLQSLPKDIFKD 541

  Fly   813 YSSVTRFYLAHNRLSDI--DQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPW 875
            .:|:....|:.|.|..:  |..|..|:.|::..|:..::|        ..:.|:...|||..|.:
Zfish   542 LTSLFFLDLSFNSLKYLPTDVFPKSLQILNLDYNSIYSVD--------PNLFSTLSYLSLMNNDF 598

  Fly   876 TCRCEDKDFLVFVKEQAKNIAN-------------------ASAIQCIDTGRSLIEVEETDICPS 921
            .|.|:.|||..::.:......:                   .|:|||.:      |.||......
Zfish   599 RCDCDLKDFQTWLNQTNVTFVHPIEDVTCASPEDQYMVPVVKSSIQCEN------EEEERRTEKL 657

  Fly   922 VLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEIC-LSLAARRELDEDK-KYDAFLSFTHK 984
            .|:.:....|.:::...|..|:|. |:.::...|:..|. |....|.|.|.|: .||.:|.|:.|
Zfish   658 RLVLFIVCTVLIILFTASTIVYIS-RRGVIFKMYKKLIGELVDGKREEPDPDRFLYDVYLCFSSK 721

  Fly   985 DEDLIEE-FVDRLEN--GRHK-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTW 1045
            |...:|. .:.||::  ..|. .|.||..||::.||.....:..:::.||:.|.:::::|||..|
Zfish   722 DMKWVERALLKRLDSQFSEHNTLRCCFEERDFIPGEDHLTNMRSAIQNSRKTICVVSEHFLKDGW 786

  Fly  1046 GRLEFRLA---LHATSRDRCKRLIVVL------------YPDVEHFDDLDSELRAYMV 1088
            ....|.||   :.|...|    ::|||            |..|..|    .|.|:|:|
Zfish   787 CLETFTLAQKRMQAELED----ILVVLVVGNIPQYRLLKYKQVRSF----IENRSYLV 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	6/24 (25%)
		leucine-rich repeat	288..308	CDD:275380	5/20 (25%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		leucine-rich repeat	335..386	CDD:275380	6/50 (12%)
		leucine-rich repeat	388..408	CDD:275380	5/24 (21%)
		LRR_8	412..465	CDD:290566	18/81 (22%)
		leucine-rich repeat	412..432	CDD:275378	9/46 (20%)
		LRR_4	432..470	CDD:289563	10/39 (26%)
		leucine-rich repeat	433..454	CDD:275378	6/22 (27%)
		leucine-rich repeat	455..478	CDD:275378	4/22 (18%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	6/29 (21%)
		leucine-rich repeat	658..679	CDD:275378	4/21 (19%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	5/11 (45%)
		leucine-rich repeat	771..791	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	5/20 (25%)
		leucine-rich repeat	836..859	CDD:275378	4/22 (18%)
		TIR	974..1110	CDD:214587	39/134 (29%)
tlr5b	NP_001124067.2	leucine-rich repeat	55..78	CDD:275380	7/35 (20%)
		leucine-rich repeat	79..103	CDD:275380	7/24 (29%)
		LRR_8	102..164	CDD:290566	20/66 (30%)
		leucine-rich repeat	104..127	CDD:275380	8/27 (30%)
		leucine-rich repeat	128..153	CDD:275380	6/24 (25%)
		leucine-rich repeat	154..178	CDD:275380	7/32 (22%)
		leucine-rich repeat	179..236	CDD:275380	12/81 (15%)
		LRR_RI	<224..478	CDD:238064	70/370 (19%)
		LRR_8	298..356	CDD:290566	15/96 (16%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	6/51 (12%)
		LRR_8	346..404	CDD:290566	22/142 (15%)
		leucine-rich repeat	348..371	CDD:275380	7/33 (21%)
		leucine-rich repeat	372..395	CDD:275380	8/82 (10%)
		LRR_8	394..451	CDD:290566	16/70 (23%)
		leucine-rich repeat	396..417	CDD:275380	6/20 (30%)
		leucine-rich repeat	441..482	CDD:275380	13/42 (31%)
		leucine-rich repeat	494..520	CDD:275380	5/45 (11%)
		LRR_8	520..577	CDD:290566	14/66 (21%)
		leucine-rich repeat	521..544	CDD:275380	5/32 (16%)
		leucine-rich repeat	545..563	CDD:275380	4/17 (24%)
		leucine-rich repeat	567..587	CDD:275380	4/27 (15%)
		LRRCT	596..645	CDD:214507	8/48 (17%)
		TIR	712..846	CDD:214587	39/133 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920