DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tlr5a

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_001919052.2 Gene:tlr5a / 403138 ZFINID:ZDB-GENE-040219-14 Length:881 Species:Danio rerio


Alignment Length:1048 Identity:205/1048 - (19%)
Similarity:372/1048 - (35%) Gaps:330/1048 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 YLYDSTVNSV---ITNNY----IRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFN 270
            :::..||.|.   .|:.|    :.:.:....||..|.      |.:.:.||              
Zfish    13 FIWTPTVKSTSVCSTDGYFAFCMDRGLQEVPKISTYI------TNVDLSKN-------------- 57

  Fly   271 GLKIKGLTNNTFENLTSLNTLIF----DNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEK 331
              :|..|...:|.:|.:|..||.    ..:.::..||:|.|.|                      
Zfish    58 --RIAELNETSFSHLEALEVLILMHQTPGLVIRRNSFMRLSNL---------------------- 98

  Fly   332 FTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNL 396
             |:|::                  .|..|.:...|            ::|             .|
Zfish    99 -TSLQL------------------DYNHHLRIDAG------------AFN-------------GL 119

  Fly   397 TTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES------- 454
            :.:.:|.:.:.|....:...|.|..|        .:|:.||:|.|.:..:.    |.|       
Zfish   120 SDLKNLTLTQCGLDDSLLSGNFLKPL--------MSLEMLDLSRNNIRRVQ----PASFFLNMRR 172

  Fly   455 LHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI 519
            .|.||:..||:.::                        |:| .|..|......|||:.:...|.:
Zfish   173 FHVLDLTFNKVKSI------------------------CEE-DLLNFQGKHFTLLRLSSITLQDM 212

  Fly   520 MEY-IELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFD 583
            .|| :.....|:..:|..:..:|   |..|.             ||:.:.:....||  .|.:..
Zfish   213 NEYWLGWEKCGNPFKNTSITTLD---LSGNG-------------FNVDMAKRFFDAI--SSTKIQ 259

  Fly   584 EIILHHL---------NSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLD-- 637
            .:|:.:.         ||..|.:.:......:|....:..|.|:       .|:.|....||.  
Zfish   260 SLIISNTYRIGKSSGDNSKDPDKSTFSGLKSSGIKSFDLSNSSI-------FSLTYSVFSYLSDL 317

  Fly   638 ------RNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRN--------- 687
                  .::|.|:.|...|   |..::.||::|:|.|..:..... :|:..|:|.:         
Zfish   318 EQITLAESQINKIENNAFL---GMTNLLKLNLSKNFLGYIDFRTF-QNLKGLEVLDLSYNHIWRL 378

  Fly   688 ---------NLLK-----------------------YLDDGVIAFLEYRENITK----IELSGNP 716
                     |||.                       ||.|..|.::....||.|    ::|..| 
Zfish   379 GSQSFQGLPNLLSLNLTGNSLGHVYTFATLPKLEKLYLGDNNIQYVYEIPNIAKHLKTLDLQFN- 442

  Fly   717 WECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLA---YVVDCS--- 775
               ...:.:.|..:....|...|.|.|..::.  .||:|        |.:.|:   .|:|.|   
Zfish   443 ---QIASMSELYTILDEFPQIEEVVFRGNQLL--YCPQD--------NHEVLSQNIQVLDLSFAG 494

  Fly   776 -------GKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI--DQ 831
                   ||.|:....|    :....|....|.|:..|..:....:|:....|:.|.|..:  |.
Zfish   495 LQVIWSEGKCLNVFDDL----HQLEVLHLSSNLLQSLPKDIFKDLTSLLILDLSFNSLKYLPTDV 555

  Fly   832 LPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDF--------LVFV 888
            .|..|:.|.:..|:..::|        ..:.|:...|||..|.:.|.|:.|||        :.||
Zfish   556 FPKTLQVLHLDYNSIYSVD--------PNLFSTLSYLSLMNNDFRCDCDLKDFQTWLNQTNITFV 612

  Fly   889 -----------KEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINV 942
                       ::|......:|:|||.|      |.||.......|:.:.|..|.:::.:.|..|
Zfish   613 HSIEDVTCASPEDQYMVPVVSSSIQCED------EEEERRTEKLRLVLFISCTVLIILFSASTIV 671

  Fly   943 FICFRQPIMIWFYEHEICLSLAARRELDEDKK---YDAFLSFTHKDEDLIEE-FVDRLEN--GRH 1001
            :|. |:.::...|: ::......:.:.:.|..   ||.:|.|:.:|...:|. .:.||::  ..|
Zfish   672 YIS-RRGVIFKIYK-KLIGKFDNKPQEEPDANGFLYDVYLCFSSRDMKWVERALLKRLDSQFSEH 734

  Fly  1002 K-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKR- 1064
            . .|.||..||::.||.....:..:::.||:.|.:::|:|||..|....|.||       :|:. 
Zfish   735 NTLRCCFEERDFIPGEDHLTNMRNAIQHSRKTICVVSKHFLKDGWCLETFTLA-------QCRML 792

  Fly  1065 ------LIVVLYPDVEHFDDLDSE-LRAYMVLNTYL-----DRNNPNFWNKLMYSMPHASHLKRS 1117
                  |:|::..::..:..|..| ||:::...:||     .::...|:::|::.:...:.:|::
Zfish   793 VELKDILVVLVVGNIPQYRLLKYEQLRSFIENRSYLVWPDDGQDLEWFYDQLLHKIIRNTKVKQT 857

  Fly  1118 RSDAETKV 1125
            ....:.||
Zfish   858 NIKEKDKV 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..308 CDD:275380 6/23 (26%)
leucine-rich repeat 309..334 CDD:275380 1/24 (4%)
leucine-rich repeat 335..386 CDD:275380 5/50 (10%)
leucine-rich repeat 388..408 CDD:275380 2/19 (11%)
LRR_8 412..465 CDD:290566 14/59 (24%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR_4 432..470 CDD:289563 12/44 (27%)
leucine-rich repeat 433..454 CDD:275378 6/20 (30%)
leucine-rich repeat 455..478 CDD:275378 5/22 (23%)
leucine-rich repeat 479..490 CDD:275378 0/10 (0%)
leucine-rich repeat 632..657 CDD:275378 7/32 (22%)
leucine-rich repeat 658..679 CDD:275378 5/20 (25%)
leucine-rich repeat 680..706 CDD:275378 9/66 (14%)
leucine-rich repeat 707..719 CDD:275378 4/15 (27%)
leucine-rich repeat 771..791 CDD:275380 7/29 (24%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 5/20 (25%)
leucine-rich repeat 836..859 CDD:275378 4/22 (18%)
TIR 974..1110 CDD:214587 38/155 (25%)
tlr5aXP_001919052.2 LRR_8 50..107 CDD:290566 18/113 (16%)
leucine-rich repeat 50..72 CDD:275380 7/37 (19%)
leucine-rich repeat 73..97 CDD:275380 6/23 (26%)
LRR_8 96..158 CDD:290566 19/135 (14%)
leucine-rich repeat 98..121 CDD:275380 8/88 (9%)
leucine-rich repeat 122..147 CDD:275380 5/32 (16%)
leucine-rich repeat 148..172 CDD:275380 7/27 (26%)
leucine-rich repeat 173..230 CDD:275380 17/81 (21%)
LRR_RI <218..478 CDD:238064 54/302 (18%)
LRR_8 291..349 CDD:290566 15/67 (22%)
leucine-rich repeat 297..316 CDD:275380 6/25 (24%)
leucine-rich repeat 317..340 CDD:275380 5/25 (20%)
LRR_8 339..399 CDD:290566 11/60 (18%)
leucine-rich repeat 341..364 CDD:275380 6/23 (26%)
leucine-rich repeat 365..388 CDD:275380 2/22 (9%)
LRR_8 387..444 CDD:290566 12/60 (20%)
leucine-rich repeat 389..410 CDD:275380 2/20 (10%)
leucine-rich repeat 411..433 CDD:275380 6/21 (29%)
leucine-rich repeat 434..513 CDD:275380 19/96 (20%)
leucine-rich repeat 485..499 CDD:275378 3/13 (23%)
LRR_8 513..570 CDD:290566 13/56 (23%)
leucine-rich repeat 514..537 CDD:275380 4/22 (18%)
leucine-rich repeat 538..559 CDD:275380 5/20 (25%)
leucine-rich repeat 560..581 CDD:275380 5/28 (18%)
LRRCT 589..638 CDD:214507 11/48 (23%)
TIR 705..839 CDD:214587 36/140 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.920

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