DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tlr5a

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_001919052.2 Gene:tlr5a / 403138 ZFINID:ZDB-GENE-040219-14 Length:881 Species:Danio rerio


Alignment Length:1048 Identity:205/1048 - (19%)
Similarity:372/1048 - (35%) Gaps:330/1048 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 YLYDSTVNSV---ITNNY----IRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFN 270
            :::..||.|.   .|:.|    :.:.:....||..|.      |.:.:.||              
Zfish    13 FIWTPTVKSTSVCSTDGYFAFCMDRGLQEVPKISTYI------TNVDLSKN-------------- 57

  Fly   271 GLKIKGLTNNTFENLTSLNTLIF----DNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEK 331
              :|..|...:|.:|.:|..||.    ..:.::..||:|.|.|                      
Zfish    58 --RIAELNETSFSHLEALEVLILMHQTPGLVIRRNSFMRLSNL---------------------- 98

  Fly   332 FTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNL 396
             |:|::                  .|..|.:...|            ::|             .|
Zfish    99 -TSLQL------------------DYNHHLRIDAG------------AFN-------------GL 119

  Fly   397 TTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES------- 454
            :.:.:|.:.:.|....:...|.|..|        .:|:.||:|.|.:..:.    |.|       
Zfish   120 SDLKNLTLTQCGLDDSLLSGNFLKPL--------MSLEMLDLSRNNIRRVQ----PASFFLNMRR 172

  Fly   455 LHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI 519
            .|.||:..||:.::                        |:| .|..|......|||:.:...|.:
Zfish   173 FHVLDLTFNKVKSI------------------------CEE-DLLNFQGKHFTLLRLSSITLQDM 212

  Fly   520 MEY-IELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFD 583
            .|| :.....|:..:|..:..:|   |..|.             ||:.:.:....||  .|.:..
Zfish   213 NEYWLGWEKCGNPFKNTSITTLD---LSGNG-------------FNVDMAKRFFDAI--SSTKIQ 259

  Fly   584 EIILHHL---------NSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLD-- 637
            .:|:.:.         ||..|.:.:......:|....:..|.|:       .|:.|....||.  
Zfish   260 SLIISNTYRIGKSSGDNSKDPDKSTFSGLKSSGIKSFDLSNSSI-------FSLTYSVFSYLSDL 317

  Fly   638 ------RNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRN--------- 687
                  .::|.|:.|...|   |..::.||::|:|.|..:..... :|:..|:|.:         
Zfish   318 EQITLAESQINKIENNAFL---GMTNLLKLNLSKNFLGYIDFRTF-QNLKGLEVLDLSYNHIWRL 378

  Fly   688 ---------NLLK-----------------------YLDDGVIAFLEYRENITK----IELSGNP 716
                     |||.                       ||.|..|.::....||.|    ::|..| 
Zfish   379 GSQSFQGLPNLLSLNLTGNSLGHVYTFATLPKLEKLYLGDNNIQYVYEIPNIAKHLKTLDLQFN- 442

  Fly   717 WECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLA---YVVDCS--- 775
               ...:.:.|..:....|...|.|.|..::.  .||:|        |.:.|:   .|:|.|   
Zfish   443 ---QIASMSELYTILDEFPQIEEVVFRGNQLL--YCPQD--------NHEVLSQNIQVLDLSFAG 494

  Fly   776 -------GKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI--DQ 831
                   ||.|:....|    :....|....|.|:..|..:....:|:....|:.|.|..:  |.
Zfish   495 LQVIWSEGKCLNVFDDL----HQLEVLHLSSNLLQSLPKDIFKDLTSLLILDLSFNSLKYLPTDV 555

  Fly   832 LPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDF--------LVFV 888
            .|..|:.|.:..|:..::|        ..:.|:...|||..|.:.|.|:.|||        :.||
Zfish   556 FPKTLQVLHLDYNSIYSVD--------PNLFSTLSYLSLMNNDFRCDCDLKDFQTWLNQTNITFV 612

  Fly   889 -----------KEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINV 942
                       ::|......:|:|||.|      |.||.......|:.:.|..|.:::.:.|..|
Zfish   613 HSIEDVTCASPEDQYMVPVVSSSIQCED------EEEERRTEKLRLVLFISCTVLIILFSASTIV 671

  Fly   943 FICFRQPIMIWFYEHEICLSLAARRELDEDKK---YDAFLSFTHKDEDLIEE-FVDRLEN--GRH 1001
            :|. |:.::...|: ::......:.:.:.|..   ||.:|.|:.:|...:|. .:.||::  ..|
Zfish   672 YIS-RRGVIFKIYK-KLIGKFDNKPQEEPDANGFLYDVYLCFSSRDMKWVERALLKRLDSQFSEH 734

  Fly  1002 K-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKR- 1064
            . .|.||..||::.||.....:..:::.||:.|.:::|:|||..|....|.||       :|:. 
Zfish   735 NTLRCCFEERDFIPGEDHLTNMRNAIQHSRKTICVVSKHFLKDGWCLETFTLA-------QCRML 792

  Fly  1065 ------LIVVLYPDVEHFDDLDSE-LRAYMVLNTYL-----DRNNPNFWNKLMYSMPHASHLKRS 1117
                  |:|::..::..:..|..| ||:::...:||     .::...|:::|::.:...:.:|::
Zfish   793 VELKDILVVLVVGNIPQYRLLKYEQLRSFIENRSYLVWPDDGQDLEWFYDQLLHKIIRNTKVKQT 857

  Fly  1118 RSDAETKV 1125
            ....:.||
Zfish   858 NIKEKDKV 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 47/274 (17%)
leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..308 CDD:275380 6/23 (26%)
leucine-rich repeat 309..334 CDD:275380 1/24 (4%)
leucine-rich repeat 335..386 CDD:275380 5/50 (10%)
PRK15370 <381..>482 CDD:185268 19/107 (18%)
leucine-rich repeat 388..408 CDD:275380 2/19 (11%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR <416..591 CDD:443914 36/191 (19%)
leucine-rich repeat 433..454 CDD:275378 6/20 (30%)
leucine-rich repeat 455..478 CDD:275378 5/22 (23%)
leucine-rich repeat 479..490 CDD:275378 0/10 (0%)
leucine-rich repeat 632..657 CDD:275378 7/32 (22%)
leucine-rich repeat 658..679 CDD:275378 5/20 (25%)
leucine-rich repeat 680..706 CDD:275378 9/66 (14%)
PCC 684..>771 CDD:188093 23/134 (17%)
leucine-rich repeat 707..719 CDD:275378 4/15 (27%)
leucine-rich repeat 771..791 CDD:275380 7/29 (24%)
PRK15370 <793..>877 CDD:185268 19/85 (22%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 5/20 (25%)
leucine-rich repeat 836..859 CDD:275378 4/22 (18%)
TIR 974..1110 CDD:214587 38/155 (25%)
tlr5aXP_001919052.2 PPP1R42 <47..183 CDD:455733 39/235 (17%)
leucine-rich repeat 50..72 CDD:275380 7/37 (19%)
leucine-rich repeat 73..97 CDD:275380 6/23 (26%)
leucine-rich repeat 98..121 CDD:275380 8/88 (9%)
leucine-rich repeat 122..147 CDD:275380 5/32 (16%)
leucine-rich repeat 148..172 CDD:275380 7/27 (26%)
leucine-rich repeat 173..230 CDD:275380 17/81 (21%)
LRR 276..>570 CDD:443914 65/322 (20%)
leucine-rich repeat 297..316 CDD:275380 6/25 (24%)
leucine-rich repeat 317..340 CDD:275380 5/25 (20%)
leucine-rich repeat 341..364 CDD:275380 6/23 (26%)
leucine-rich repeat 365..388 CDD:275380 2/22 (9%)
leucine-rich repeat 389..410 CDD:275380 2/20 (10%)
leucine-rich repeat 411..433 CDD:275380 6/21 (29%)
leucine-rich repeat 434..513 CDD:275380 19/96 (20%)
leucine-rich repeat 485..499 CDD:275378 3/13 (23%)
leucine-rich repeat 514..537 CDD:275380 4/22 (18%)
leucine-rich repeat 538..559 CDD:275380 5/20 (25%)
leucine-rich repeat 560..581 CDD:275380 5/28 (18%)
LRRCT 589..638 CDD:214507 11/48 (23%)
TIR 705..839 CDD:214587 36/140 (26%)

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