DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and tlr8a

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_001920594.5 Gene:tlr8a / 403137 ZFINID:ZDB-GENE-040219-13 Length:1019 Species:Danio rerio


Alignment Length:1112 Identity:217/1112 - (19%)
Similarity:399/1112 - (35%) Gaps:318/1112 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 LSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKT-------M 232
            ||.|.:|.:......:...:..|..|.:..|.|:........:|....::.|||:..       :
Zfish    19 LSELNVRILKTQPCDIHENITAETVVVNCRGRKLKVLPQFLANTTYIDLSENYIKNLTVQSFHGL 83

  Fly   233 NNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVF 297
            .|...:.:.:.|  :...:.:.|.:|....|:..|..||:|:|.:..:..:||..|         
Zfish    84 ENLTLLNLNWLN--QNREVVIAKGVFSNLTKLRVLDLNGIKLKYIPKDIPKNLEKL--------- 137

  Fly   298 LKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCK 362
                     |.:::.:|:        ::|.:||...||.::.:|.       ..:...|.....:
Zfish   138 ---------SLVENKITW--------INLTTFEHVKNLSVLYLSN-------NCYYWNPCSRRYR 178

  Fly   363 FTLGINEVACPLK-CNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELPDN 425
            ...|.......|| ...|:|             |||.:| .|||   ....|...||.|..:.::
Zfish   179 IEKGSLSYLVNLKRLTLSFN-------------NLTQVPIGLPV---SLERLELGSNSLTYIGEH 227

  Fly   426 SLEGYHNLKSLDVSYN--------------QLTSLSV-----SQLPESLHYLDIRHNKITTLSPQ 471
            ...|..||..|.:..|              :.||:.:     |.| .:||.|.:..|.|.:::|.
Zfish   228 DFRGLFNLTVLKIQGNCPRCHTAPYPCIPCKNTSIEIHPQAFSDL-RNLHILHLAGNSIKSINPA 291

  Fly   472 VVEYLYSV-NVFNQYGNKWSIYCD--------------EYHLQEFFWYKAKLL------------ 509
            ....|.:: .:|..:...:|...|              :..|...|.:|...|            
Zfish   292 WFANLSNLQQLFLSFNLLFSAITDPADTVFLGNLPLLTKLDLSYNFAFKTYPLTVVLSPGFANLT 356

  Fly   510 -------------RIKTSKFQTI--MEYIELSSKG----SFVENFFVQNIDQLYLEANE------ 549
                         :|:...|:::  ::::.:...|    .|..::..|::..|||..|.      
Zfish   357 SLRSLHLRGLVFRKIQKDTFKSLFDLQHLNVLDVGVNFIVFATSYIFQHVRLLYLAENRLYPVTV 421

  Fly   550 ---------------------DEIIDAFG------PSDKYFNLKLMEALNHAIWLFSGE-FDEII 586
                                 .|.:|.|.      .|:.|...::::...:.::|.|.| ||.. 
Zfish   422 NGELSKATFVGSNHRSIMPLMAEPLDTFDAPKNLVKSECYNAGRVLDLSRNNLFLISPEQFDTY- 485

  Fly   587 LHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLV 651
                                |.  |:|.|||.:.:...||.           :|...|.|.:.| 
Zfish   486 --------------------GN--ISCLNLSRNGFSTAPNG-----------SEFTSLPNLKYL- 516

  Fly   652 VAGHASIHKLHMS-QNLLRELPLHLLPENITYLDVRNNLLKYLDDGV---IAFLEYRENITKIEL 712
               ..|.:|:.:: .|..|||      :::..||:..|...:...||   :.||:|..::..:.:
Zfish   517 ---DLSFNKVDLAYDNAFREL------QSLEVLDISYNSHYFTVAGVTHNMMFLQYLPSLKVLNM 572

  Fly   713 SGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKC-----PEDCICCVDTSNSDSLAYVV 772
            |.|  ..|......:|          ...||.::...:|.     .:|....:...|..:|.: :
Zfish   573 SFN--SINTLTTKTMS----------SKSLRELQFRGNKLGRMWRDKDNTYVMIFKNFTNLIH-L 624

  Fly   773 DCSGKELSEIPQLPTPTYGQTTLVFER-----NSLKKWPSSLLPGYSSVTRFYLAHNRLSDID-- 830
            |.|...:.:||.   ..|.|..:..:|     |.|.....::|..:.::....|..|.:.:|.  
Zfish   625 DISNNSIGKIPY---TVYTQLPITIQRLQMSHNQLANINWTMLRRFQNLRELILHDNNIIEIASN 686

  Fly   831 ---QLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLS----------------------L 870
               .:| .||.|::.:|..|.|   ..||||..:|..:|.||                      |
Zfish   687 LSVDVP-SLELLNLQHNRISKL---AIGFLQGVVNLKELDLSYNYLITVNQSTFPTESDLKMLWL 747

  Fly   871 FGNPWTCRCEDKDFLVFVKEQAKNIAN-ASAIQC-IDTGRSLIEVEETDICPSV------LIYYT 927
            .|||:.|.|...:|::::.:....|.. .:.:.| :...|..:.|.:.||...:      :.|:.
Zfish   748 HGNPFHCTCNLLEFVLWILDTNVKIPRLVTGVTCTMPEERKGLAVIKFDIQECIDDQLAFVAYFI 812

  Fly   928 SLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAAR----REL-DEDKKYDAFLSFTHKDED 987
            |.|..:.....:|.:.:.:.....:::|       |.||    ::| .|...||||:::..||..
Zfish   813 SAACIICTTFAAITMHLFYWDVSYLYYY-------LKARFTGYQQLSSESCIYDAFITYDTKDPQ 870

  Fly   988 LIEEFVDRL-----ENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGR 1047
            :.:..::.|     |.......:|...|||:.|..:.|.:.||::.||:.:.::|:.::.|.   
Zfish   871 VSDWVLNHLRVQLEERSELFLPICLEERDWIPGSPVLDSLTQSIQNSRKTVFVLTEGYVNSG--- 932

  Fly  1048 LEFRLAL---HATSRDRCKRLIVVLY--PDVE--HFDDLDSELRAYMVLNTYLDRNNPNFWNKLM 1105
             .|:||:   |....:..:.:||:|.  |.::  ||..|...|.|..:|.          |    
Zfish   933 -SFKLAVFLAHQRLLEENEDVIVLLLLEPVLQHSHFVRLRRRLCARSILE----------W---- 982

  Fly  1106 YSMPHAS 1112
               ||:|
Zfish   983 ---PHSS 986

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 7/22 (32%)
leucine-rich repeat 288..308 CDD:275380 1/19 (5%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
leucine-rich repeat 335..386 CDD:275380 8/51 (16%)
leucine-rich repeat 388..408 CDD:275380 7/20 (35%)
LRR_8 412..465 CDD:290566 17/71 (24%)
leucine-rich repeat 412..432 CDD:275378 5/19 (26%)
LRR_4 432..470 CDD:289563 13/56 (23%)
leucine-rich repeat 433..454 CDD:275378 7/39 (18%)
leucine-rich repeat 455..478 CDD:275378 7/22 (32%)
leucine-rich repeat 479..490 CDD:275378 1/11 (9%)
leucine-rich repeat 632..657 CDD:275378 4/24 (17%)
leucine-rich repeat 658..679 CDD:275378 5/21 (24%)
leucine-rich repeat 680..706 CDD:275378 8/28 (29%)
leucine-rich repeat 707..719 CDD:275378 2/11 (18%)
leucine-rich repeat 771..791 CDD:275380 4/19 (21%)
leucine-rich repeat 793..815 CDD:275378 4/26 (15%)
leucine-rich repeat 816..835 CDD:275378 4/23 (17%)
leucine-rich repeat 836..859 CDD:275378 9/22 (41%)
TIR 974..1110 CDD:214587 35/147 (24%)
tlr8aXP_001920594.5 NEL <15..>226 CDD:330839 50/257 (19%)
leucine-rich repeat 62..112 CDD:275380 8/51 (16%)
leucine-rich repeat 113..133 CDD:275380 5/19 (26%)
LRR_8 133..200 CDD:316378 17/112 (15%)
leucine-rich repeat 134..157 CDD:275380 7/48 (15%)
leucine-rich repeat 158..189 CDD:275380 4/37 (11%)
PLN00113 189..>702 CDD:331614 110/590 (19%)
leucine-rich repeat 190..234 CDD:275380 16/59 (27%)
leucine-rich repeat 235..274 CDD:275380 7/39 (18%)
leucine-rich repeat 275..298 CDD:275380 7/22 (32%)
leucine-rich repeat 299..327 CDD:275380 3/27 (11%)
leucine-rich repeat 328..357 CDD:275380 4/28 (14%)
leucine-rich repeat 358..381 CDD:275380 2/22 (9%)
leucine-rich repeat 465..487 CDD:275380 5/42 (12%)
leucine-rich repeat 488..512 CDD:275380 9/34 (26%)
leucine-rich repeat 513..536 CDD:275380 7/32 (22%)
leucine-rich repeat 537..566 CDD:275380 8/28 (29%)
leucine-rich repeat 567..620 CDD:275380 9/64 (14%)
leucine-rich repeat 621..645 CDD:275380 7/27 (26%)
leucine-rich repeat 646..669 CDD:275380 4/22 (18%)
leucine-rich repeat 670..693 CDD:275380 4/23 (17%)
LRR_8 692..752 CDD:316378 18/63 (29%)
leucine-rich repeat 694..717 CDD:275380 10/25 (40%)
leucine-rich repeat 718..736 CDD:275380 3/17 (18%)
TPKR_C2 750..>789 CDD:326558 8/38 (21%)
TIR 858..1000 CDD:214587 38/150 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.