DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tlr8b

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001373638.1 Gene:tlr8b / 403136 ZFINID:ZDB-GENE-040219-12 Length:1015 Species:Danio rerio


Alignment Length:1128 Identity:236/1128 - (20%)
Similarity:395/1128 - (35%) Gaps:368/1128 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   200 VHHANG-----PKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFH 259
            ||.:.|     .|:.....|.:::|....:..|::|...|.         .:..|.|.:..|..|
Zfish    11 VHSSEGYNWAWRKLPCDVNLSNTSVTLDCSERYLKKIPKNL---------IWNTTNLNLANNKIH 66

  Fly   260 GKNKMSALIFNGL-----------KIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSL 313
            ..:|.:....|.:           |.....|..|..||:|.||:.||   ..:|.| ...|.:.|
Zfish    67 NISKDAFWNLNNVTWIDLRRNQIEKCHEKDNGVFSRLTNLKTLLLDN---NKISVL-PKNLPAGL 127

  Fly   314 TYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNC 378
            .:        :.|.|    .:::.||.|.:||....|             .|.:|:       ||
Zfish   128 QW--------LSLNS----NHIKSIEQSDFKGMTKLT-------------VLKLNK-------NC 160

  Fly   379 SYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQL 443
             |:...::|.|    :|.|                ||...|.|| ..|..|.||:.         
Zfish   161 -YHNISAELTI----QNET----------------FQHLQLTEL-QLSKNGLHNVP--------- 194

  Fly   444 TSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAK- 507
                 ..||.:||.|.:..|:|..:....:.:|..:.|.:..||     |.......|.....: 
Zfish   195 -----FALPRTLHNLSLLLNRIDHVHESDLNHLTRLKVLDLSGN-----CPICFTTPFPCTSCQT 249

  Fly   508 ---LLRIKTSKFQTIMEYIELSSKGSFVEN----FF--VQNIDQLYLEAN--------------- 548
               .|:|..:.|..:.:..:|...|:.:::    :|  :.|:..|||..|               
Zfish   250 NNNALQIHPNAFSKLSQLQDLRLSGNSLQSINSMWFQNLTNLKYLYLSFNSLISEFESGQFFSVL 314

  Fly   549 -EDEIIDAF--GPSDK-YFNLKLMEALNHAIWLFSGEFDEIILHHLNS----PCPYRCSCCFEWH 605
             :.|::|..  .||:: |..|||.|..:....|.:...:..|.|.|:.    |            
Zfish   315 PQVEVVDISYNNPSERIYPRLKLSEGFSRLESLQTLHLEGYIFHKLSEDDLRP------------ 367

  Fly   606 TGEFLINCRNLS----------------------LDIYPRLPNSIPYKTTL-------------- 634
                |.:.||||                      |.:...:.|.:.:.:.:              
Zfish   368 ----LFSLRNLSVLNLAVNFLQQVNLSVFRNFHNLSLISLIDNRLTFSSPIRRWEGQSKSGFKDD 428

  Fly   635 ---------YLDRNE----IRKLTNTESLVVAGHASIHKLHMSQNLLREL--PLHLLPENITYLD 684
                     |:..||    ....|..|.|     |:...|.:|:|.:..:  ||....||||.|:
Zfish   429 NQGDHREGPYIHTNEEFRHYPPFTKAECL-----ATGPVLDLSRNNIYHVNPPLFTGAENITCLN 488

  Fly   685 VRNNL---------------LKYLD----------DGVIAFLEYRENITKIELSGNP--WEC--- 719
            :.:|.               |||||          |..::.|:..|   .::||.|.  :|.   
Zfish   489 LSSNFIVSYFNGTEFAHFPKLKYLDLSHNRIYMHSDSALSELKALE---VLDLSHNQHYFEVAGV 550

  Fly   720 -NCKAKAFLSFLRRHEPMEYETVL----RRVEITDDKCPEDCICCVDTSNSDSLAYV-------- 771
             ||     |:||   |.:::..||    ..:.:..:|          |..||||..:        
Zfish   551 RNC-----LTFL---ENLQFLKVLNLSWNEINMLTNK----------TLQSDSLNELQFQGNRLD 597

  Fly   772 ---------------------VDCSGKELSEIPQLPTPTYGQTT--LVFERNSLKKWPSSLLPGY 813
                                 :|.|..:|||||......:.:|.  :...||:|..:....|...
Zfish   598 IMWKKQRGYQSLFKSLSNLTYLDISYNKLSEIPDDIFDYFPKTLRYISMSRNTLTDFAWEQLQSL 662

  Fly   814 SSVTRFYLAHNRLSDIDQLPDK----LEYLDISNNNFSAL---------DDRVRGFLQKRM---- 861
            ..:....|:.|:|..:.:...|    |:.||:|:|..|.|         ..::..|...::    
Zfish   663 PQLETLDLSKNKLRVVPRKLSKHTRSLKVLDLSHNQISKLRYSFLENVKSLQILNFANNKLKHLG 727

  Fly   862 -------NSSQLQ-LSLFGNPWTCRCEDKDFLVFVKEQAKNIAN-ASAIQC----IDTGRSLIEV 913
                   ::.||| |.|..||..|.|...||::::::....:.. |:.:.|    ...|..::.:
Zfish   728 ASSFTTGSNHQLQILDLQRNPIHCTCNLLDFILWLEKSDTILPRLATDVLCDLPESKRGHPMVSL 792

  Fly   914 EETDIC----PSVLIYYTSLAVSLLIIALSINVFICFRQPIMIW--FYEHEICLSLAARREL-DE 971
            :..:.|    .:.::|..:.:|..|::..:|.:.:.:      |  .|.:..|::......| ..
Zfish   793 DFKNACINNSIAEILYILTSSVITLVMCTTIGIHVFY------WDISYAYNFCMARFKSYYLKTN 851

  Fly   972 DKKYDAFLSFTHKDEDLIEEFVDRL-----ENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRR 1031
            |..||||:.:..||..:.|..::.|     :.|||...||...|||..|..|.|.:|.||..||:
Zfish   852 DCIYDAFVMYDTKDPMVAEWVLNHLRLELEDRGRHVRPLCLEERDWTPGIPIMDNLNLSVHRSRK 916

  Fly  1032 IIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDR- 1095
            .|.::|:.|:.|...::...||......:....:::||         |:..||...:||  |.| 
Zfish   917 TIFVLTEGFVHSGIFKMAAFLAQQRLLEEGVDVMVLVL---------LEPVLRQSRILN--LRRC 970

  Fly  1096 ----------NNPN----FWNKL 1104
                      .||.    ||..|
Zfish   971 LCGHSVLEWPRNPAAEGWFWQSL 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 5/33 (15%)
leucine-rich repeat 288..308 CDD:275380 7/19 (37%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
leucine-rich repeat 335..386 CDD:275380 11/50 (22%)
leucine-rich repeat 388..408 CDD:275380 3/19 (16%)
LRR_8 412..465 CDD:290566 15/52 (29%)
leucine-rich repeat 412..432 CDD:275378 7/19 (37%)
LRR_4 432..470 CDD:289563 8/37 (22%)
leucine-rich repeat 433..454 CDD:275378 2/20 (10%)
leucine-rich repeat 455..478 CDD:275378 6/22 (27%)
leucine-rich repeat 479..490 CDD:275378 3/10 (30%)
leucine-rich repeat 632..657 CDD:275378 6/51 (12%)
leucine-rich repeat 658..679 CDD:275378 5/22 (23%)
leucine-rich repeat 680..706 CDD:275378 11/50 (22%)
leucine-rich repeat 707..719 CDD:275378 3/13 (23%)
leucine-rich repeat 771..791 CDD:275380 7/48 (15%)
leucine-rich repeat 793..815 CDD:275378 5/23 (22%)
leucine-rich repeat 816..835 CDD:275378 3/18 (17%)
leucine-rich repeat 836..859 CDD:275378 8/31 (26%)
TIR 974..1110 CDD:214587 44/151 (29%)
tlr8bNP_001373638.1 leucine-rich repeat 36..57 CDD:275380 3/29 (10%)
leucine-rich repeat 58..78 CDD:275380 4/19 (21%)
LRR_8 64..116 CDD:404697 13/54 (24%)
leucine-rich repeat 79..105 CDD:275380 4/25 (16%)
leucine-rich repeat 106..121 CDD:275380 7/18 (39%)
LRR_8 126..190 CDD:404697 24/117 (21%)
leucine-rich repeat 127..150 CDD:275380 8/34 (24%)
leucine-rich repeat 151..179 CDD:275380 12/68 (18%)
PLN00113 180..>735 CDD:215061 120/616 (19%)
leucine-rich repeat 180..224 CDD:275380 15/58 (26%)
leucine-rich repeat 225..266 CDD:275380 8/45 (18%)
leucine-rich repeat 267..290 CDD:275380 3/22 (14%)
leucine-rich repeat 347..373 CDD:275380 6/41 (15%)
leucine-rich repeat 374..397 CDD:275380 2/22 (9%)
leucine-rich repeat 462..483 CDD:275380 5/20 (25%)
leucine-rich repeat 484..508 CDD:275380 4/23 (17%)
leucine-rich repeat 509..532 CDD:275380 7/22 (32%)
leucine-rich repeat 563..615 CDD:275380 8/61 (13%)
leucine-rich repeat 586..607 CDD:275380 1/20 (5%)
leucine-rich repeat 616..640 CDD:275380 7/23 (30%)
leucine-rich repeat 641..664 CDD:275380 4/22 (18%)
leucine-rich repeat 665..688 CDD:275380 4/22 (18%)
leucine-rich repeat 689..712 CDD:275380 7/22 (32%)
leucine-rich repeat 713..732 CDD:275380 1/18 (6%)
LRRCT 747..795 CDD:214507 9/47 (19%)
TIR 855..997 CDD:214587 44/150 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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