DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr22

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001122147.2	Gene:	tlr22 / 403135	ZFINID:	ZDB-GENE-040220-5	Length:	955	Species:	Danio rerio

Alignment Length:	1125	Identity:	239/1125 - (21%)
Similarity:	400/1125 - (35%)	Gaps:	336/1125 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 NGTCSIANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNET-DYELVIISVLGIRSEVDM 166
            |.|.|.:..::.|   |.|::..|:.. :|.|        ::.|.| ..::...|...|:.| |:
Zfish    35 NCTISSSQKDIKT---QPKVLCYKMNF-FTIP--------RVPNNTWILDISFNSFAQIQIE-DL 86

  Fly   167 RISPAVQYL----------------SLLGIREI-----------SGYDIYLPSVLITEMDVHHAN 204
            .|...:|||                ||..:.::           :|....|.::|:..:|.::.:
Zfish    87 NILLNLQYLNVSNNKISKIQDGAFGSLFNLTDLNLASNRLNAVSNGMLRGLTNLLVLRLDRNYIS 151

  Fly   205 GPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIK----------IY----YHNTFEKTTLTME- 254
            ..|...|     ||::|:...|..:..:.:.:.:|          :|    |.|.|..:.|:.:
Zfish   152 VIKESAF-----STLHSLQVLNLSKNHLRHIDDVKPVLASLYLEELYIGSNYFNVFNSSELSTKP 211

  Fly   255 ---KNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSF-----------LR 305
               |.:....|:.:|.        .||||.|..|..|           |||:           ..
Zfish   212 LSLKRLDLSNNRFAAF--------QLTNNIFPTLNHL-----------DLSYCGHNGTMAWNVTE 257

  Fly   306 SSTLQSSLTYCIMKV-------DNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKF 363
            .|.|.|..|...|.|       ||:  |:||....|...:..:......:....:|.|.....:.
Zfish   258 KSYLASVKTLYFMDVNMSIQTADNV--LQSFNNTLNKIRLNGNVRLNKTSLLLSVCSPMLRVLRL 320

  Fly   364 TLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLE 428
                  :|..:|...::..|                     |....|.|....|.::.|..:...
Zfish   321 ------IATKIKHLTNHMFD---------------------PCSELSELDLGGNEISNLSQSMFR 358

  Fly   429 GYHNLKSLDVSYNQLTSLSVS-QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWS-- 490
            |:..||.|.:..|:||.::.| |:..||.::|:..|.|..||......|..|.....|.||.|
Zfish   359 GFKQLKKLQLQINKLTRVTNSFQILTSLEFIDLSRNHIHKLSCNDFANLTQVKTLYLYSNKISSI 423

  Fly   491 ---IYCDEYHLQEFFWYKAKLLRIKTSKFQTI----------MEYIELS-SKGSFVENFFVQNID 541
               ::.|...|:        :||:.|:....|          ::.::|| :|.|.:::....|:.
Zfish   424 RSCLFKDLKSLE--------VLRLGTNNLLKIDDVFSNGPYFLKELQLSYNKLSLIKSHTFGNLP 480

  Fly   542 Q---LYLEANEDEIID--AFGPSDKYFNLKLM------EALNHAIWLFSGEFDEIILHHLNSPCP 595
            |   |.||.|:...|:  |||..:...:|.|.      :.|.....:|||
Zfish   481 QLNNLSLEDNQISEIEGYAFGGLENLTSLFLSSNKITGKTLTTHPNVFSG--------------- 530

  Fly   596 YRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPY-----KTTLYLDRNEIRKLTNTESLVVAGH 655
                          :.|.:||.|     ..|||.:     |..|:.|...:|:|:
Zfish   531 --------------MPNLQNLDL-----FANSISFAYDKLKYPLFKDLKNLRELS---------- 566

  Fly   656 ASIHKLHMSQNLLRELPLHLLPENITYLD---VRNNLLKYLDDGVIAFLEYRENITKIELSGNPW 717
                 |:..:..:.:||.:|| |.::.|.   :.|..|..|:..:..|   ...:..::||.|
Zfish   567 -----LYSQRRGIGQLPSNLL-EGLSSLQMFYIGNTNLNQLNPNLFNF---TPQLWFLDLSKN-- 620

  Fly   718 ECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEI 782
                                   .||.    ||..|
Zfish   621 -----------------------ALRE----DDAIP----------------------------- 629

  Fly   783 PQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQ-----LPDKLEYLDIS 842
            |:|..|....|.|:..|..|:.....|....:.::....:.|.:..:::     || :|..||:.
Zfish   630 PELFHPIPNLTKLIISRTQLRSLNFLLGANLNKLSTLRASGNEIDSVNETLIKSLP-RLAVLDLQ 693

  Fly   843 NNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKE-QAKNIANASAIQC--- 903
            ||.|                             ||.|.:..|:.:.|: ::..:...|...|
Zfish   694 NNTF-----------------------------TCDCNNAFFIDWAKKNESTQVYYLSRYTCSYP 729

  Fly   904 -IDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFI--CFRQPIMIWFYEHEICLSLAA 965
             ...|.||.|. .||.|.....|...:..|:|:|...:..||  ..|..::..:|.....|..:.
Zfish   730 RTLRGTSLAEF-NTDSCTFNWDYICFVCSSILVILTLLLSFIWNFLRYQVVYTYYLFLAFLYDSR 793

  Fly   966 RRELDEDKKYDAFLSFTHKDED-LIEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGS 1029
            |.:..:..:||||:|:...||. ::||.:.:|| |...:|||.:.||:..|..|.|.|...:..|
Zfish   794 RNQSGQTFQYDAFISYNTLDEAWVMEELIPKLE-GEQGWRLCLHHRDFEPGRPIIDNIVDGIYSS 857

  Fly  1030 RRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDV-EHFDDLDSELRAYMVLNTYL 1093
            |:.|.|:|:|:|||.|...|.::|......::...||:|...|: .|.......||..:...||:
Zfish   858 RKTICLITRNYLKSNWCSSEVQVASFRLFDEQKDVLILVFLEDIPTHQLSPYHRLRKLVKKRTYI 922

  Fly  1094 -----DRNNPNFWNKLMYSM 1108
                 ..:|..||.||..::
Zfish   923 RWPKPGEDNKIFWQKLKMAL 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..308	CDD:275380	4/30 (13%)
		leucine-rich repeat	309..334	CDD:275380	10/31 (32%)
		leucine-rich repeat	335..386	CDD:275380	5/50 (10%)
		leucine-rich repeat	388..408	CDD:275380	1/19 (5%)
		LRR_8	412..465	CDD:290566	16/53 (30%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	14/38 (37%)
		leucine-rich repeat	433..454	CDD:275378	8/21 (38%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	4/10 (40%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	5/28 (18%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	3/23 (13%)
		leucine-rich repeat	836..859	CDD:275378	6/22 (27%)
		TIR	974..1110	CDD:214587	47/142 (33%)
tlr22	NP_001122147.2	leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		LRR_RI	461..700	CDD:238064	69/379 (18%)
		LRR_8	480..544	CDD:290566	20/97 (21%)
		leucine-rich repeat	482..505	CDD:275380	8/22 (36%)
		leucine-rich repeat	506..533	CDD:275380	6/55 (11%)
		leucine-rich repeat	534..561	CDD:275380	9/31 (29%)
		LRR_8	560..622	CDD:290566	16/105 (15%)
		leucine-rich repeat	562..587	CDD:275380	8/40 (20%)
		leucine-rich repeat	588..606	CDD:275380	4/17 (24%)
		leucine-rich repeat	612..638	CDD:275380	11/83 (13%)
		LRR_8	637..695	CDD:290566	11/58 (19%)
		leucine-rich repeat	639..662	CDD:275380	5/22 (23%)
		leucine-rich repeat	663..686	CDD:275380	3/23 (13%)
		leucine-rich repeat	687..705	CDD:275380	9/46 (20%)
		TIR	802..945	CDD:214587	47/142 (33%)
		leucine-rich repeat	71..91	CDD:275380	5/20 (25%)
		LRR_8	91..150	CDD:290566	9/58 (16%)
		leucine-rich repeat	92..115	CDD:275380	5/22 (23%)
		leucine-rich repeat	116..139	CDD:275380	2/22 (9%)
		LRR_8	138..199	CDD:290566	10/65 (15%)
		leucine-rich repeat	140..163	CDD:275380	6/27 (22%)
		leucine-rich repeat	164..213	CDD:275380	7/48 (15%)
		leucine-rich repeat	214..338	CDD:275380	31/171 (18%)
		LRR_8	337..396	CDD:290566	17/58 (29%)
		leucine-rich repeat	339..362	CDD:275380	5/22 (23%)
		LRR_RI	<363..494	CDD:238064	37/138 (27%)
		leucine-rich repeat	363..385	CDD:275380	8/21 (38%)
		LRR_8	384..444	CDD:290566	18/67 (27%)
		leucine-rich repeat	386..409	CDD:275380	7/22 (32%)
		leucine-rich repeat	410..433	CDD:275380	6/22 (27%)
		LRR_8	432..492	CDD:290566	15/67 (22%)
		leucine-rich repeat	434..457	CDD:275380	5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920