DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tlr19.1

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001352353.1 Gene:tlr19.1 / 403134 ZFINID:ZDB-GENE-040220-3 Length:958 Species:Danio rerio


Alignment Length:1192 Identity:223/1192 - (18%)
Similarity:398/1192 - (33%) Gaps:448/1192 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 CEIYLDELGENGTCSIANNEVTTEDYQMKLVFLKLEINWTSPVFH--GWNIFKICNETDY----- 150
            |.:.|..:.:.  |      :|.|::.:|      ::.||....|  |...:..||.||.     
Zfish    24 CNVVLTRITKR--C------ITIEEHLLK------QMPWTPHCLHYPGKGPYANCNITDLSTDLS 74

  Fly   151 ---------------------------ELVIISVLGIRSEVDMRIS-------PAVQYLSLL--- 178
                                       .|.::.:.|||.|   |:.       |.::|||:|   
Zfish    75 QVGFEVRTLCVFGDITSIPAKAFSHLPSLEVLHIDGIRLE---RVQAGAFEGLPNLKYLSMLFSD 136

  Fly   179 -------------------------GIREISGYD-IYLPSVLITEMDVHH-------------AN 204
                                     |:..::|.. |:.|.|.:..:|:..             :|
Zfish   137 ELYRLVRIDNRSFAGLNNLEELSLTGLMLLNGSSGIFDPLVSLIRLDIVRTCAQDLGEIFCCISN 201

  Fly   205 GPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIF 269
            |...:....:.||.::::........:|            |:..|.|:..:|::...|.:..:..
Zfish   202 GMTRLRHLNVEDSEISTIENKGCPGGSM------------TWPLTALSGVQNLYLIGNNIKYIQA 254

  Fly   270 NGLKIKGLTNNTFENLTSL--------------------NTLIFDNVFL-------KDLSFLRSS 307
            |.|.|       |:||:||                    |.|......|       |||..|.||
Zfish   255 NSLII-------FQNLSSLFLEFEGKSLGSIWESGVGKVNDLTLKGKVLKKYSTNFKDLCHLVSS 312

  Fly   308 TLQSSLTYCIMKVDNMV--DLKSF-EKFTNLEIIEVSQYKG--FKNFTAFICEPYKSHCKFTLGI 367
            ....||:.....:|.:.  |||.. .|.|.| :|:.|:...  |:.:|:          |..:..
Zfish   313 LYSQSLSLVYTSIDRLTAEDLKDCGTKLTKL-LIQNSKIDNLDFRFWTS----------KLEMQA 366

  Fly   368 NEVA------CPLKCNCSYNRDKSQLEIDCWQKNLTTIPS-----LPVPKKGSSALVFQSNLLAE 421
            .::|      .|. |..:.:...|...:|....::|.|..     :|..::    |....|.:..
Zfish   367 LQMAYMKLTDAPF-CFVANSTMWSLTSLDLTGNSITNIEGDQFACMPFLEQ----LYLSQNAIKT 426

  Fly   422 LPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQ-- 484
            |..::..|...||.|.:..|::..||.:.      :.::|..::..::..::|.:.:...::|  
Zfish   427 LQLHAFRGLPRLKILQLDSNKIWQLSAND------FKNLRALEVLLINDNIIETIETGTFWDQRE 485

  Fly   485 -----YGNKWSIYCDEYHLQE-FFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQL 543
                 :|....:|  |.||:. ||.:..||.|              ||....:..|.::.|.   
Zfish   486 LCELSFGRLEYVY--ELHLENIFFEFPPKLQR--------------LSIDAHYGTNIYIGNA--- 531

  Fly   544 YLEANEDEIIDAFGPSDKYFNLKLM-EALNHAIWLFSGEFDEIIL--HHLNSPCPYRCSCCFEWH 605
                         .|.:..|.|:|. |.|.     |.|...::::  ..|...|.|  ..|.:..
Zfish   532 -------------SPPNGTFALELNGERLG-----FVGCDSDVLMAVRELKVNCTY--FLCKDSF 576

  Fly   606 TGEFLINCRNLSLD-IYPRLP------NSIPYKTTLYL----------DRNEIRKLTNTESLVVA 653
            ...:.:|..:|.:. ...|.|      |::.:...|.|          .|:....||..::||| 
Zfish   577 MAPYFLNLESLEISGGAERAPLNYATINNLHHLKHLKLARLNFPNYTESRSAFWNLTQLQTLVV- 640

  Fly   654 GHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWE 718
              .:.|...:::::.|:|      .::..|.:.::....|.|||...|..   :....|....::
Zfish   641 --VNCHLSFLTKSMFRDL------TSLQLLRLYSDSPLILTDGVFGVLPV---LKAFILDRVDFQ 694

  Fly   719 CNCK-----------AKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDC--ICCVDTSNSDSLAY 770
            |:|:           .|..:.:|::.:.:.:...|..:...:..|..|.  ||.|.|::|.||  
Zfish   695 CSCENGWLLDWADSTEKVQVIYLQKQQCVWHYQKLNFLATMEKLCQTDAQYICYVATASSISL-- 757

  Fly   771 VVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDK 835
                          |.:...|.        ...:|||.:|                         
Zfish   758 --------------LLSAAVGY--------QFARWPSLVL------------------------- 775

  Fly   836 LEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASA 900
              :|            |::|::::|          ||..|..|                      
Zfish   776 --FL------------RLKGWMERR----------FGRRWNRR---------------------- 794

  Fly   901 IQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAA 965
                   |..:|.:..:|                                               
Zfish   795 -------RRRMEDDYGEI----------------------------------------------- 805

  Fly   966 RRELDEDKKYDAFLSFTHKDED-LIEEFVDRL-ENGRHKFRLCFYLRDWLVGESIPDCINQSVKG 1028
                 |:.:||||:||..:||. ::.|...|| |.|..:.|||.:.||:.||:.|.|.|..|:..
Zfish   806 -----EEMQYDAFVSFCSQDEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDIMDNITDSIHN 865

  Fly  1029 SRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVL---- 1089
            |:..:.|:::.:|:|.|..||.|:|.|....::..|||::....:..|     ||.|:..|    
Zfish   866 SQCTVCLISRRYLRSDWCGLEMRVATHRQLEEQKHRLILIFLQHISPF-----ELSAFHRLAKLV 925

  Fly  1090 --NTYLD-----RNNPNFWNKL 1104
              .||||     .:..:||::|
Zfish   926 RSRTYLDWPEEEGDREHFWDRL 947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 9/46 (20%)
leucine-rich repeat 309..334 CDD:275380 7/27 (26%)
leucine-rich repeat 335..386 CDD:275380 9/58 (16%)
leucine-rich repeat 388..408 CDD:275380 4/24 (17%)
LRR_8 412..465 CDD:290566 11/52 (21%)
leucine-rich repeat 412..432 CDD:275378 4/19 (21%)
LRR_4 432..470 CDD:289563 7/37 (19%)
leucine-rich repeat 433..454 CDD:275378 6/20 (30%)
leucine-rich repeat 455..478 CDD:275378 2/22 (9%)
leucine-rich repeat 479..490 CDD:275378 2/17 (12%)
leucine-rich repeat 632..657 CDD:275378 8/34 (24%)
leucine-rich repeat 658..679 CDD:275378 3/20 (15%)
leucine-rich repeat 680..706 CDD:275378 6/25 (24%)
leucine-rich repeat 707..719 CDD:275378 1/11 (9%)
leucine-rich repeat 771..791 CDD:275380 1/19 (5%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 0/18 (0%)
leucine-rich repeat 836..859 CDD:275378 3/22 (14%)
TIR 974..1110 CDD:214587 49/144 (34%)
tlr19.1NP_001352353.1 LRR_8 101..162 CDD:316378 11/63 (17%)
leucine-rich repeat 103..126 CDD:275380 6/25 (24%)
leucine-rich repeat 127..154 CDD:275380 4/26 (15%)
leucine-rich repeat 155..178 CDD:275380 4/22 (18%)
leucine-rich repeat 179..238 CDD:275380 9/70 (13%)
leucine-rich repeat 207..219 CDD:275378 2/11 (18%)
leucine-rich repeat 239..265 CDD:275380 8/32 (25%)
leucine-rich repeat 340..363 CDD:275380 7/33 (21%)
leucine-rich repeat 364..389 CDD:275380 3/25 (12%)
LRR_8 389..448 CDD:316378 13/62 (21%)
leucine-rich repeat 390..413 CDD:275378 3/22 (14%)
leucine-rich repeat 414..437 CDD:275378 4/26 (15%)
LRR_8 436..>482 CDD:316378 8/51 (16%)
leucine-rich repeat 438..461 CDD:275378 6/28 (21%)
leucine-rich repeat 462..485 CDD:275378 2/22 (9%)
leucine-rich repeat 540..562 CDD:275380 6/26 (23%)
leucine-rich repeat 563..608 CDD:275380 9/46 (20%)
leucine-rich repeat 609..634 CDD:275380 4/24 (17%)
leucine-rich repeat 635..658 CDD:275380 6/31 (19%)
TIR 809..952 CDD:214587 49/144 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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