DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and tlr18

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001082819.1 Gene:tlr18 / 403133 ZFINID:ZDB-GENE-040220-2 Length:854 Species:Danio rerio


Alignment Length:995 Identity:221/995 - (22%)
Similarity:361/995 - (36%) Gaps:325/995 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 NIFHGKNKMSALI-FNGLK--IKGLTNNTFENLTSL-NTLIFDNVFLKDLSFLRSSTLQSSLTYC 316
            :|.|.|.|.|..| |:.|.  .|||      .|.|: .|.:.|::...||||        :..:.
Zfish    16 HIKHAKAKQSCTIAFDKLSADCKGL------RLDSVPTTQLPDSLEELDLSF--------NTIHV 66

  Fly   317 IMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYN 381
            |.|.|       |.|.|.|.:::                         |..|.::..|.      
Zfish    67 IRKQD-------FVKLTYLRVLK-------------------------LNFNNISLVLD------ 93

  Fly   382 RDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVS------- 439
                    |.:|.||..           ..|...:|.|.|:|..:||...|||.|::|       
Zfish    94 --------DAFQGNLLL-----------EELNLFNNSLTEIPFKALEPLTNLKVLEMSNNLYSQA 139

  Fly   440 --------YNQLTSLSV-SQLPESL--------------------------------------H- 456
                    :|||..||: ..|..||                                      | 
Zfish   140 SLGAAFLNFNQLKVLSIGGPLVSSLGSRDIYVLKNISLDKFAVKTGTGFRDYEPGYFKSLSTKHL 204

  Fly   457 YLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAK---LLRIKTSKFQT 518
            :.||..:|...|.|::::.|         .||........:|.||.:|..|   ...::....||
Zfish   205 WFDIAFDKNPDLLPKMLKDL---------ANKTFDVLRFRNLFEFQYYTGKRDIFYGLQYVNAQT 260

  Fly   519 IMEYIELSSKGSFVENFF---VQNIDQLYLEANEDEIID-------AFGPSDKYFNLKLMEALNH 573
            :..|     :|.|.|...   ::|::...::|.|..:||       ..|.|.|  ||.|      
Zfish   261 LTFY-----RGKFNEEVMRMALKNVEISPIKALELLLIDFARSQNRTQGSSVK--NLSL------ 312

  Fly   574 AIWLFSGEFDEIILHHLNSPCPYRCSCCFEW--HTGEFL---INCRNLSLDIYPRLPN--SIPYK 631
                     |.::|..:::|...|....|.|  |..:|:   :|..::..|.:|.:.:  .:...
Zfish   313 ---------DRLVLSDISNPDIMRFDWSFTWLNHVRKFIVWNVNFNSVPCDSWPEMKSVELLDIS 368

  Fly   632 TTLYLDRNEIRKLTNTESLVVAGHASIHKL---HMSQNLLREL-PLHLLPEN---ITYLDVRNNL 689
            ....||......|.:|.:       ::|||   ::|.|.|..| .|..|.::   :|.:|:.:|.
Zfish   369 NNQLLDSYIYNPLCDTRN-------TLHKLDTFNVSHNRLTSLSDLASLTKDFVKLTTIDMSHNQ 426

  Fly   690 LKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPE 754
            |:||.:|.   .::|:.|||:  .||                 |..:                ..
Zfish   427 LQYLGNGA---CDWRKTITKV--IGN-----------------HNSL----------------TS 453

  Fly   755 DCICCVDTS-NSDSLAYVVDCSGKELSEIPQLPTPTYGQ----TTLVFERNSLKKWPSSLLPGYS 814
            |...|:.|| |...|:|         |.:.||....:.:    |.|:...|.:|..||    |:.
Zfish   454 DSFKCLPTSVNFLDLSY---------SSLDQLDMDYFNKASELTELLLSGNKIKFIPS----GWK 505

  Fly   815 SVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRC 879
                     ||.         |..|.:..|:|..:.  ::.|  |.|.|.:: |:...||:.|.|
Zfish   506 ---------NRY---------LRTLALDGNSFGLVS--MKSF--KDMLSLRV-LTAGNNPYHCTC 547

  Fly   880 EDKDFLVFVKEQAK----NIAN-ASAIQCIDTGRSLIEVEE--------TDICPSVLIYYTSLAV 931
               |...|::|...    .|.: .:..:|....|.|..:..        .||...::|..::.|.
Zfish   548 ---DLYTFIQETTSKGKVTITDWPNNYKCYHPERLLNTMVSKYSPGHLACDITLVIIISVSTTAA 609

  Fly   932 SLLIIALSINVFIC--FRQPIMIWFYEHEICLSLAARRELDE------DKKYDAFLSFTHKDEDL 988
            .:|:|.|     :|  |..|   |:.:....:..|..|...|      |..:.||:|::|.|.|.
Zfish   610 VVLVIML-----LCYIFHVP---WYVKATYQIIRAKYRAHKEGLGQGVDYAFHAFISYSHSDADW 666

  Fly   989 I-EEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRL 1052
            : ...:..|||.:..:|||.:.||::.|:.|.|.|.::::.||::|.:::.||:.|.|...|...
Zfish   667 VRNHLLPCLENVKPPYRLCIHERDFIPGKWIIDNIIENIENSRKVIFVLSHNFVNSEWCNYELYF 731

  Fly  1053 A-LHATSRDRCKRLIVVLYP-DVEHFDDLDSELRAYMVLNTYLD-RNNPN----FWNKL--MYSM 1108
            | ..|..:.....::||..| |.........:|:..:...|||: ...|.    ||.:|  :...
Zfish   732 AQQRAIGKTFSDVILVVKEPIDPTSLPSKFCKLKRMLNTKTYLEWPQQPTEQNFFWIQLRSVLGK 796

  Fly  1109 PHA---------SHLKRSRS 1119
            |::         |.|..:||
Zfish   797 PNSIRPRTISRHSRLSSARS 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 8/25 (32%)
leucine-rich repeat 288..308 CDD:275380 6/20 (30%)
leucine-rich repeat 309..334 CDD:275380 5/24 (21%)
leucine-rich repeat 335..386 CDD:275380 4/50 (8%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
LRR_8 412..465 CDD:290566 23/107 (21%)
leucine-rich repeat 412..432 CDD:275378 7/19 (37%)
LRR_4 432..470 CDD:289563 18/92 (20%)
leucine-rich repeat 433..454 CDD:275378 10/36 (28%)
leucine-rich repeat 455..478 CDD:275378 8/61 (13%)
leucine-rich repeat 479..490 CDD:275378 2/10 (20%)
leucine-rich repeat 632..657 CDD:275378 4/24 (17%)
leucine-rich repeat 658..679 CDD:275378 9/24 (38%)
leucine-rich repeat 680..706 CDD:275378 8/25 (32%)
leucine-rich repeat 707..719 CDD:275378 5/11 (45%)
leucine-rich repeat 771..791 CDD:275380 3/19 (16%)
leucine-rich repeat 793..815 CDD:275378 7/21 (33%)
leucine-rich repeat 816..835 CDD:275378 2/18 (11%)
leucine-rich repeat 836..859 CDD:275378 5/22 (23%)
TIR 974..1110 CDD:214587 40/145 (28%)
tlr18NP_001082819.1 LRR_8 53..>98 CDD:316378 15/98 (15%)
leucine-rich repeat 54..77 CDD:275380 9/37 (24%)
leucine-rich repeat 78..101 CDD:275380 7/61 (11%)
leucine-rich repeat 102..125 CDD:275380 7/33 (21%)
leucine-rich repeat 126..150 CDD:275380 4/23 (17%)
LRR <345..>519 CDD:227223 52/249 (21%)
leucine-rich repeat 362..390 CDD:275380 4/34 (12%)
leucine-rich repeat 391..416 CDD:275380 7/24 (29%)
leucine-rich repeat 417..440 CDD:275380 8/25 (32%)
leucine-rich repeat 441..462 CDD:275380 8/55 (15%)
leucine-rich repeat 463..486 CDD:275380 6/31 (19%)
leucine-rich repeat 487..508 CDD:275380 8/33 (24%)
leucine-rich repeat 509..532 CDD:275380 7/26 (27%)
TIR 653..791 CDD:214587 39/137 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 1 1.000 - - FOG0000239
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.920

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