DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and tlr4bb

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_997978.2 Gene:tlr4bb / 403132 ZFINID:ZDB-GENE-040219-9 Length:819 Species:Danio rerio


Alignment Length:944 Identity:208/944 - (22%)
Similarity:369/944 - (39%) Gaps:276/944 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 ITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTS 287
            :|..|||:                      :||:.|:....:..||..|..|..|......:|..
Zfish    83 LTRCYIRQ----------------------IEKDAFYNVKNLMTLILTGNPITYLAPECLNSLYK 125

  Fly   288 LNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTN-LEIIEVSQYKG-FKNFT 350
            |..|:..:|.|:.|.               ::::|:..|:..:..|| ::.:.:..:.. ||:|:
Zfish   126 LQRLVLVDVRLESLQ---------------LQINNLTKLQDLKVGTNCIQSMTLPSFMSTFKDFS 175

  Fly   351 AFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTI----PSLPVPKKGSSA 411
            .           ..|..|.::.....:.:..|:..        :|:|.|    |.:.: :.|:  
Zfish   176 L-----------LDLHANNISIIRMDHTAVLREIG--------RNMTLILSRNPLIHI-EPGA-- 218

  Fly   412 LVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYL 476
              |:..:|.||  :.|..:.:..:....:..||.|:|.:|....:.:|   .||....|..:|.|
Zfish   219 --FKDVILREL--HLLAAFISFNAQKECHKALTGLTVDKLFVGRYRMD---EKIKVSVPDYLEGL 276

  Fly   477 YSVNVFNQ---YGNKWSIYCDEYHL-------QEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSF 531
            .|:| ||:   ...:||  ..|.||       .:....||.:..:|...|..:.| :.||..|..
Zfish   277 CSIN-FNEIYLVQKEWS--DSEMHLFRCMVNATKITIKKAYMNSMKHIPFHRLKE-LYLSDTGLS 337

  Fly   532 VENFF--VQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPC 594
            |..|.  :.::::|.:::...  |...|.||    |.|::.::     .||..  :|||      
Zfish   338 VVPFISHIPSLEKLVMKSPFP--ITFTGVSD----LPLLQYVD-----LSGNM--LILH------ 383

  Fly   595 PYRCSCCFEWHTGEFLINCRNLSLDIYPRLPN---------------SIPYKTTLYLDRNEIRKL 644
                .||               |: ::||.||               :.|:..   ||..|:...
Zfish   384 ----ECC---------------SI-LFPRTPNIQYLNLSQNSEITFVNEPFSA---LDLLEVLDF 425

  Fly   645 TNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLD-----VRNNLLKYLDDGVIAFLEYR 704
            .:|: ||:..:....|             ||  .|:.|||     |..|.|.:.|         .
Zfish   426 HHTK-LVIVFYFGFFK-------------HL--RNLKYLDISYTRVHFNTLTFQD---------L 465

  Fly   705 ENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLA 769
            .|:|.::::||            ||                                  :.|.|:
Zfish   466 HNLTVLKMAGN------------SF----------------------------------SGDKLS 484

  Fly   770 YVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQL-- 832
            |.:    :.|:.:..|.....|     .|:.|::.:     .|...:...||:.|:|..:|.|  
Zfish   485 YFL----QNLTSLEVLDISQCG-----IEKVSMRSF-----TGTQKLRHLYLSRNKLMVLDFLTQ 535

  Fly   833 PDKLE----YLDISNNNFSALDDRVRGFLQK-RMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQA 892
            |:...    |:|.::.....||     .||| .||.|:..||  .|...|.|...||::::.::.
Zfish   536 PELTHLTSVYIDKNSITTIPLD-----VLQKLPMNLSEFDLS--SNSIDCSCSQTDFILWIIQKQ 593

  Fly   893 KNIANASAIQC----IDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMI- 952
            ..:.....|:|    .:|....|:. :.|.|    ::...|.:.|.:|.::..|.:.    |:: 
Zfish   594 NILKQLENIRCKTFSANTDFKAIDF-DIDYC----VHKKRLTIVLSVICVTFVVVLA----ILLY 649

  Fly   953 --WFYEHEICLSLAA--RRELDEDKKYDAFLSFTHKDED-LIEEFVDRLENGRHKFRLCFYLRDW 1012
              |||. :.|..|.:  |....::..||||:.|:..||. ::.|.::.||||....:||.::||:
Zfish   650 KFWFYV-QYCFILFSGYRSPGQQECSYDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDF 713

  Fly  1013 LVGESI-PDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDV-EH 1075
            ..|:|| .:.|::.:.|||:||::::::|:.|:|.|.||.||......:|...:|:::..|| |.
Zfish   714 QAGKSIASNIIDEGIMGSRKIIVVVSQHFIDSSWCRFEFELAQSRFLMERNANIIIIILEDVAER 778

  Fly  1076 FDDLDSELRAYMVLNTYL-----DRNNPNFWNKL 1104
            .......|..::..||||     ..:|..||.:|
Zfish   779 KTKKVFGLHKHLKKNTYLKWSRDPLSNMRFWIRL 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 5/19 (26%)
leucine-rich repeat 309..334 CDD:275380 2/24 (8%)
leucine-rich repeat 335..386 CDD:275380 6/51 (12%)
leucine-rich repeat 388..408 CDD:275380 4/23 (17%)
LRR_8 412..465 CDD:290566 11/52 (21%)
leucine-rich repeat 412..432 CDD:275378 5/19 (26%)
LRR_4 432..470 CDD:289563 8/37 (22%)
leucine-rich repeat 433..454 CDD:275378 5/20 (25%)
leucine-rich repeat 455..478 CDD:275378 6/22 (27%)
leucine-rich repeat 479..490 CDD:275378 3/13 (23%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 3/20 (15%)
leucine-rich repeat 680..706 CDD:275378 7/30 (23%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 2/19 (11%)
leucine-rich repeat 793..815 CDD:275378 3/21 (14%)
leucine-rich repeat 816..835 CDD:275378 7/20 (35%)
leucine-rich repeat 836..859 CDD:275378 5/26 (19%)
TIR 974..1110 CDD:214587 47/139 (34%)
tlr4bbNP_997978.2 leucine-rich repeat 56..77 CDD:275380
LRR_8 77..133 CDD:290566 15/71 (21%)
leucine-rich repeat 78..101 CDD:275380 7/39 (18%)
leucine-rich repeat 102..125 CDD:275380 6/22 (27%)
leucine-rich repeat 126..148 CDD:275380 6/36 (17%)
leucine-rich repeat 149..173 CDD:275380 4/23 (17%)
leucine-rich repeat 174..200 CDD:275380 4/44 (9%)
leucine-rich repeat 201..222 CDD:275380 6/25 (24%)
LRR_RI <325..531 CDD:238064 62/333 (19%)
leucine-rich repeat 326..369 CDD:275380 12/49 (24%)
leucine-rich repeat 370..395 CDD:275380 10/57 (18%)
LRR_8 394..455 CDD:290566 16/79 (20%)
leucine-rich repeat 396..419 CDD:275380 2/25 (8%)
leucine-rich repeat 420..444 CDD:275380 7/39 (18%)
LRR_8 443..527 CDD:290566 26/152 (17%)
leucine-rich repeat 445..467 CDD:275380 7/30 (23%)
leucine-rich repeat 468..492 CDD:275380 9/73 (12%)
LRR_8 491..576 CDD:290566 25/101 (25%)
leucine-rich repeat 493..516 CDD:275380 5/32 (16%)
leucine-rich repeat 517..540 CDD:275380 7/22 (32%)
leucine-rich repeat 541..565 CDD:275380 7/28 (25%)
TIR 675..816 CDD:214587 47/138 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.920

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