DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr9

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001124066.1	Gene:	tlr9 / 403128	ZFINID:	ZDB-GENE-040219-10	Length:	1057	Species:	Danio rerio

Alignment Length:	1161	Identity:	222/1161 - (19%)
Similarity:	394/1161 - (33%)	Gaps:	410/1161 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 MDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKT-------MNNTEKIKIYYHNTFEK------- 248
            :|..|....|:.  ::...|.::..:.||:|.:.       :.|.:.:.:.::...::
Zfish    40 VDCQHRRLSKVP--RFTSPSVISLNLNNNHIHRIKGDAFSGLPNLKYLSLMWNCISDRLKEARWP 102

  Fly   249 -TTLTMEKNIFHGKNKMSALIFNG------------LKIKGLT-NNTFENLTSLNT------LIF 293
             .::.::.:.|.|...:::|...|            |::.||. ||.|..:..|.|      |:.
Zfish   103 LCSVNIDPDAFVGLKNLTSLQLAGNSLKMIPPLPKQLEVLGLEFNNIFNIVKPLGTPQLKQLLLS 167

  Fly   294 DNVFLKDLS----FLRSSTLQS-------SLTYCIMKV---------------DNMVDLKSFEKF 332
            .|.|..:..    |:.||..|.       :|:|..:..               :|.:|..:.|.|
Zfish   168 KNCFYANPCHQPYFINSSVFQDLPELLNLTLSYNNLTAIPSYLPGSLESLDLRENTIDHINKESF 232

  Fly   333 TNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLT 397
            .||..:.....    .:....|:.....|        ..||       |.....|..|.:.....
Zfish   233 ANLRNLRHLNL----GWNCQRCDHASDPC--------FPCP-------NNQSLDLHQDAFLDQRD 278

  Fly   398 TIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVS-------------YNQLTSLSVS 449
            ::.||.:          |.|.|..||.:.....|.|:.||:|             |.:|.::.:.
Zfish   279 SLVSLHL----------QGNSLRTLPRHLFINLHKLQELDLSSNFLAFTIQNGTFYEELQNVVIL 333

  Fly   450 QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYK------AKL 508
            .|  ..:|..::......||| .:|.:.|:.              |.:|..||:.|      |.|
Zfish   334 NL--LYNYEPLKTFPELNLSP-YIEKMASLR--------------ELYLSGFFFKKLSNRSIAPL 381

  Fly   509 LRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLY------LEAN---------------EDEI 552
            :::..      :|.::|  :.:|:.:..:..:.||.      |..|               |.:|
Zfish   382 VKLPR------LEVLDL--RMNFICDISIDGLSQLRTLRRVDLSQNMLAFSSCFSTCTSEAEHQI 438

  Fly   553 IDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPC----PYRCSCCFE-WH------- 605
            .:.:|  ::.|||::.|                 |..||:..    |..||..|. ||
Zfish   439 PERYG--NEQFNLQMQE-----------------LPILNAETQGSKPDYCSFYFSMWHFKRQICS 484

  Fly   606 --------------------TGEFLINCRNLSLDIYPRLPNSIPY--------------KTTLYL 636
                                .|...:.|.:||.:...:..|...:              :..||.
Zfish   485 KSLYFDLSQNNIPWLNASTFRGMDRVACVDLSYNYISQTLNGHQFSHLSKLSYLNMAYNRIDLYS 549

  Fly   637 DR----------------NE---IRK--------LTNTESLVVAGHASIHKLHMSQNLLRELPLH 674
            |:                ||   |.|        ||:..||::...|:.|......|:|....|.
Zfish   550 DKAFQEVSGTLKALDLSNNEFHFIMKGMGHQFTFLTHMSSLIILSLANNHIGLRISNILTSASLK 614

  Fly   675 LL------------------------PENITYLDVRNNLLKYLDDGVIAFLEYRENITKIE---L 712
            .|                        ..|:|:||:..|.||.|...||..|.....:.:::   |
Zfish   615 YLIFSGNRLDILWDSWRNQYINLFQGLTNLTHLDISENQLKSLSPEVIVNLPLSLQVLRVDFNML 679

  Fly   713 SGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGK 777
            :..||       |.:|.|::                        :|.::.| |:.|:|
Zfish   680 TYFPW-------ANISVLQK------------------------LCYLNLS-SNMLSY------- 705

  Fly   778 ELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQL----PDKLEY 838
                   ||       .:.||..               :|...|:||||..|.::    ...|:.
Zfish   706 -------LP-------NINFELR---------------LTGLDLSHNRLVAIPKVFLSQAANLKN 741

  Fly   839 LDISNNNFSALDDRV------RG--FLQ--KRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAK 893
            |:::||....||.:.      :|  |:.  :..|.|..:|.|..||:||.|....|..|::|...
Zfish   742 LNLNNNQLKILDVQALPLPFHKGCTFIPGGQHKNRSSCKLVLHANPFTCSCVISGFAKFLRETDL 806

  Fly   894 NIAN-ASAIQC-IDTGRSLIEVEETDI--CPSVLIYYTSLAVSLLIIALSINVFICFRQPIM--- 951
            ::.: .:.:.| .....:.:.|...|:  |..:......|..|||.:|.:     |.  |::
Zfish   807 DVPHLTTQVHCGFPESLAGVNVLSVDLRSCQEIFGGVAFLCTSLLTLAAT-----CV--PLLKHL 864

  Fly   952 ----IWFYEHEICLSLAARRELD---EDKKYDAFLSFTHKDED----LIEEFVDRLEN-GRHKFR 1004
                :|:....:..........:   .|.:||||:.|...::.    :.:|.:.|||| ||.:|:
Zfish   865 YGWDLWYLIQILWTGHRGHTPANGNPTDTQYDAFVVFDTSNKAVRDWIYKEMLVRLENRGRWRFQ 929

  Fly  1005 LCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWG--------RLEFRLALHATSRDR 1061
            ||...|||:.|.|..:.:::||..||:.:.::|     |..|        |..|.|.......::
Zfish   930 LCLEERDWIPGVSCIENLHKSVYSSRKTVFVLT-----SPGGYSDASGIVRQAFLLVQQRLLDEK 989

  Fly  1062 CKRLIVV----LYPDVEHFDDLDSELRAYMVLNTYLD-----RNNPNFWNKLMYSM 1108
            ....::|    |:|..::.     ::|..:...:.|.     |..|.|||.|..::
Zfish   990 VDVAVLVLLDFLFPKFKYL-----QMRKRLCKKSVLSWPRNPRVQPLFWNDLRVAL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/35 (23%)
		leucine-rich repeat	288..308	CDD:275380	7/29 (24%)
		leucine-rich repeat	309..334	CDD:275380	7/46 (15%)
		leucine-rich repeat	335..386	CDD:275380	6/50 (12%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	14/65 (22%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	9/50 (18%)
		leucine-rich repeat	433..454	CDD:275378	7/33 (21%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	11/51 (22%)
		leucine-rich repeat	658..679	CDD:275378	5/44 (11%)
		leucine-rich repeat	680..706	CDD:275378	10/25 (40%)
		leucine-rich repeat	707..719	CDD:275378	3/14 (21%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	2/21 (10%)
		leucine-rich repeat	816..835	CDD:275378	7/22 (32%)
		leucine-rich repeat	836..859	CDD:275378	8/32 (25%)
		TIR	974..1110	CDD:214587	41/157 (26%)
tlr9	NP_001124066.1	leucine-rich repeat	39..57	CDD:275380	3/18 (17%)
		LRR_8	56..129	CDD:290566	9/72 (13%)
		leucine-rich repeat	58..81	CDD:275380	3/22 (14%)
		LRR_RI	<73..312	CDD:238064	47/267 (18%)
		leucine-rich repeat	82..118	CDD:275380	2/35 (6%)
		leucine-rich repeat	119..138	CDD:275380	2/18 (11%)
		leucine-rich repeat	139..192	CDD:275380	15/52 (29%)
		LRR_8	191..246	CDD:290566	8/58 (14%)
		leucine-rich repeat	193..213	CDD:275380	2/19 (11%)
		leucine-rich repeat	214..237	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..279	CDD:275380	7/59 (12%)
		LRR_RI	274..>422	CDD:238064	35/182 (19%)
		leucine-rich repeat	280..303	CDD:275380	7/32 (22%)
		leucine-rich repeat	304..323	CDD:275380	4/18 (22%)
		leucine-rich repeat	360..386	CDD:275380	7/39 (18%)
		leucine-rich repeat	387..408	CDD:275380	3/22 (14%)
		LRR_8	490..545	CDD:290566	5/54 (9%)
		leucine-rich repeat	490..509	CDD:275380	1/18 (6%)
		leucine-rich repeat	510..534	CDD:275380	4/23 (17%)
		leucine-rich repeat	535..559	CDD:275380	3/23 (13%)
		leucine-rich repeat	560..589	CDD:275380	6/28 (21%)
		leucine-rich repeat	590..612	CDD:275380	5/21 (24%)
		LRR_8	612..679	CDD:290566	13/66 (20%)
		leucine-rich repeat	613..643	CDD:275380	2/29 (7%)
		leucine-rich repeat	644..668	CDD:275380	10/23 (43%)
		leucine-rich repeat	669..692	CDD:275380	6/29 (21%)
		leucine-rich repeat	693..714	CDD:275380	9/42 (21%)
		TIR_2	894..1040	CDD:304906	41/155 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820