DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001124065.1	Gene:	tlr1 / 403127	ZFINID:	ZDB-GENE-040220-1	Length:	795	Species:	Danio rerio

Alignment Length:	881	Identity:	186/881 - (21%)
Similarity:	315/881 - (35%)	Gaps:	291/881 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 KNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSL---SVSQLPESL 455
            :||:::|.  ..|..:..|....|.:..|..........|:.|::|:|.|.::   :.:..| :|
Zfish    35 QNLSSVPD--DLKPSTEDLDLSLNHIQSLNCRDFNTTPRLRFLNLSWNILENIDRDTFTSTP-AL 96

  Fly   456 HYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI- 519
            ..||:.||.:..||.|  .||..:.            |.|            ||.:.:::|..:
Zfish    97 EMLDLSHNGLQNLSEQ--PYLLHLG------------CLE------------LLDLSSNRFSAMA 135

  Fly   520 ----------MEYIELSSKGSFVENF-FVQNIDQLYLEANEDEIIDAFGPS-DKYFNLKLMEAL- 571
                      ::::.||:|...:::| .:.|:....|..|.|.::...|.| |.....|.:.||
Zfish   136 LGEEFSMLKRLQWLGLSAKSISIQDFTHISNLTLRTLFINADGLLTYEGNSLDDVHAEKAVIALS 200

  Fly   572 ---------NHAIWLFSG-EFDEI-----ILHHLNSPC---PYRCSCCFEWHTGEFLIN------ 612
                     |.....|.. ||.::     ::..:.|..   ..|........|.|||.:
Zfish   201 STNVDIAIANDVFARFKEVEFTKVDGKMEVVQQMRSRALMRTVRLEISNVKTTWEFLTSSVNTIL 265

  Fly   613 ---CRNLSL-----------------DIYPRLPNSIPYKTTLYLDRNEI---------RKLTNTE 648
               .|.|||                 .|...........||...|:..:         ||::.||
Zfish   266 SSTIRELSLTDLTLTEMKDGANQSSTHILESFSTKRASVTTFIFDQKMLYDFFINTPARKVSLTE 330

  Fly   649 SLVV----AGHAS-IHKLHMSQNLLRELPLHLLPE-------NITYLDVRNNLLKYLDDGVIAFL 701
            |.::    .|..| |.:|.:|...|.|....:.||       |:|.|.:|.|.||:|..     |
Zfish   331 SPIIFMTCPGTISKIQELDLSDCALTEKIFSVNPETECGTLVNLTRLVLRGNNLKHLSP-----L 390

  Fly   702 EYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSD 766
            ..|.|:                                                         .|
Zfish   391 TSRINL---------------------------------------------------------MD 398

  Fly   767 SLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLK-KWPSSLL------PGY---------SS 815
            ||.|:      :||           |.||.:..|..: .||..:|      .|:         .|
Zfish   399 SLQYI------DLS-----------QNTLTYSENQGRCFWPPRVLHVDLSRNGFDEVVFKCLPDS 446

  Fly   816 VTRFYLAHNRLS----DIDQLPDKLEYLDISNNNFSALDDRVRGF--LQK---RMNS-------- 863
            |....|.|||:|    ||... |.|:.:|::.|....| ...|.|  |||   |.||
Zfish   447 VQVLNLRHNRVSTVPADIHTF-DTLQVIDLTFNRLLDL-PTCRSFPSLQKLLIRSNSIHSPVPGS 509

  Fly   864 ----SQLQ-LSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIE----------- 912
                ..|| |.|..||:.|.|..:||...:..|.           |.|.:|.::
Zfish   510 LKTCQHLQDLDLSHNPFICTCALRDFASLINAQG-----------IKTFKSTLKHWPDGYRCSYP 563

  Fly   913 ------VEETDICPSVLIYYTSLAVSLLIIALSINV---FICFRQPI-----MIWFYEHEICLSL 963
                  ..|....|.:......||:::||..:|:.|   .:|.|..|     |:|.:......|:
Zfish   564 ESWSNSTLEDFYLPEISCNAWILAITILIPTISLIVAVSLLCNRLDIPWYVRMMWKWTRAKHYSI 628

  Fly   964 AAR-RELDEDK-KYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQS 1025
            .:: :|.|.:: .:.||:|::.|:...:: :|:.:|| |....|:|.:.||::.|:::...|.:.
Zfish   629 TSQLKEEDVERLHFHAFVSYSQKNAGWVKSQFLPKLE-GDCGLRMCHHERDFIPGKTVVQNILRC 692

  Fly  1026 VKGSRRIIILMTKNFLKSTWGRLEFRLALH-ATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVL 1089
            ::.|||.:.:::.:|::|.|...|...|.| ..:|.....|:::|.|           |..|::
Zfish   693 IEQSRRCVFVLSSHFVQSEWCHYELYFANHQKLTRGMDSILLILLEP-----------LPLYLI- 745

  Fly  1090 NTYLDRNNPNFWNKLMYSMPHASHLKRSRSDAETKV 1125
                    |:.:.:|...|...::|:..:..|:.|:
Zfish   746 --------PSKYYQLKTMMSRRTYLEWPQEGAKQKL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380	4/13 (31%)
		LRR_8	412..465	CDD:290566	14/55 (25%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	12/40 (30%)
		leucine-rich repeat	433..454	CDD:275378	6/23 (26%)
		leucine-rich repeat	455..478	CDD:275378	10/22 (45%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	9/37 (24%)
		leucine-rich repeat	658..679	CDD:275378	7/27 (26%)
		leucine-rich repeat	680..706	CDD:275378	9/25 (36%)
		leucine-rich repeat	707..719	CDD:275378	0/11 (0%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	7/37 (19%)
		leucine-rich repeat	816..835	CDD:275378	8/22 (36%)
		leucine-rich repeat	836..859	CDD:275378	7/24 (29%)
		TIR	974..1110	CDD:214587	32/137 (23%)
tlr1	NP_001124065.1	LRR_8	46..106	CDD:290566	14/60 (23%)
		leucine-rich repeat	48..71	CDD:275380	3/22 (14%)
		leucine-rich repeat	72..95	CDD:275380	6/23 (26%)
		leucine-rich repeat	109..145	CDD:275380	10/61 (16%)
		leucine-rich repeat	146..166	CDD:275380	4/19 (21%)
		leucine-rich repeat	346..373	CDD:275380	6/26 (23%)
		LRR_8	373..457	CDD:290566	30/162 (19%)
		leucine-rich repeat	374..399	CDD:275380	10/86 (12%)
		leucine-rich repeat	400..425	CDD:275380	10/41 (24%)
		leucine-rich repeat	426..446	CDD:275380	2/19 (11%)
		leucine-rich repeat	447..469	CDD:275380	8/22 (36%)
		LRR_8	469..526	CDD:290566	17/57 (30%)
		leucine-rich repeat	470..491	CDD:275380	6/21 (29%)
		leucine-rich repeat	492..515	CDD:275380	6/22 (27%)
		TPKR_C2	524..>565	CDD:301599	10/51 (20%)
		TIR	642..783	CDD:214587	35/153 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020