DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr3

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001013287.2	Gene:	tlr3 / 403126	ZFINID:	ZDB-GENE-040219-7	Length:	903	Species:	Danio rerio

Alignment Length:	930	Identity:	182/930 - (19%)
Similarity:	330/930 - (35%)	Gaps:	288/930 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 FICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPS-LPVPKKGSSALVFQ 415
            :.|  :.:||..|....:.||.:|          ..:.||...||..||: ||.   ..:.|...
Zfish    13 YAC--FSAHCAGTTNARKSACMIK----------NAKADCSHMNLDAIPTDLPT---NITTLDVS 62

  Fly   416 SNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVS---QLPESLHYLDIRHNKITTLSPQVVEYLY 477
            .|.|..|  :||..|.||.::|.|||.|..:...   .||. |.:|:::||::..:|.:.::..:
Zfish    63 HNRLKTL--SSLHMYTNLVNIDASYNSLAGIEKDLCLSLPH-LQFLNVQHNQVYLISEKNLKNCF 124

  Fly   478 SVNVFNQYGNKWSIYCDEYH-LQEFFWYKAKLLRIKTSKFQT------------------IM--- 520
            .:...:...||..:..:.:. |:...|......::.::|..|                  |:
Zfish   125 HLTQLDLSDNKLKLQGEPFSLLKNLTWLDVSRNKLTSAKLGTEPQLPNLVTLVLSGNNINILQEN 189

  Fly   521 EYIELSSKGSF------------VENFFVQNIDQLYLEANEDEIIDAFGPSDKY----------- 562
            ::..||:..||            |||...:.||.|     .|.::|:...:.::
Zfish   190 DFSFLSNSSSFRVLILSSLILKKVENGCFKAIDTL-----SDLVLDSSKLTSQFTTSLFEELADT 249

  Fly   563 ----FNLKLMEALNHAIWLFSG-EFDEIILHHLNSPCPYRCS----CCFEWHTGEFLINCRNLSL 618
                .:||..|.:..:...|.| |..:|.:..|:.   .|.|    ..|:|
Zfish   250 ALRNLSLKSTEQVTLSNTTFQGLEKTKITVLDLSE---NRISKIVDGAFQW-------------- 297

  Fly   619 DIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLR---ELPL------- 673
                     :|....|.|:.|.||.|||..   .:|..::.:|::.:.|::   .||:
Zfish   298 ---------LPQLEFLSLEHNTIRHLTNDS---FSGLGNLRQLNLRKALIKSHASLPVIDDFSFQ 350

  Fly   674 HLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWEC----NCKAKAFLSF----- 729
            ||:  .:.||.:.|...:.|.:.:.:.|   .|:..::||   |..    ....|.|...
Zfish   351 HLV--QLEYLCMANTAFRELTEQIFSGL---RNLKTLDLS---WSITGIKTVTNKTFAGLQESPL 407

  Fly   730 ----------LRRHEP-------------MEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYV 771
                      :.:.||             |....:.::::..:.|...: |..:|.|.:.....:
Zfish   408 LQTLNLTGMGINKLEPGAFSSLGNLSNLLMSRNFINQQLQGNEFKGLSN-IKEIDMSINQQSISL 471

  Fly   772 VDCSGKELSEIPQL-------------PT---PTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFY 820
            .:.|...:|.:..|             |:   |....|.|....|::....:.||.|..::....
Zfish   472 TNASFVHVSTLRTLKLGRALKGTLDMEPSPFRPLVNLTILDLSNNNIANINADLLEGLYNLKVVK 536

  Fly   821 LAHNRLSDIDQLPD------------KLEYLDISNNNFSAL-DDRVRGF---------------- 856
            :.||.|:.:.::.:            .|.||::..|....: .:..|||
Zfish   537 MQHNNLARLWKMANPGGPVLFLKDATNLSYLNLDYNGIDEIPPNAFRGFSELHELSLRGNLLDQL 601

  Fly   857 ---------------LQKRMNSSQLQLSLFG-------------NPWTCRCEDKDFLVFVKEQAK 893
                           |||.:.:| :|.:.||             ||:.|.||.   :::..|...
Zfish   602 HASVFDDLNSLKYLHLQKNLITS-VQRATFGVPLSKLKELNMDHNPFDCTCES---ILWFSEWLN 662

  Fly   894 ------------------------NIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLL 934
                                    ::.|...:.|            .|:.|...:|..|....|:
Zfish   663 STNTSVPGFPQSYICNTPNAYFNHSVMNFDPLSC------------KDMTPFKALYILSSTAVLM 715

  Fly   935 IIALSINVFICFRQPIMIWFY----EHEICLSLAARRELDEDKKYDAFLSFTHKDEDLIEEFVDR 995
            ::.:|   |:...|...|.||    .:.:..||...:..:...::||::....:|:..:|..:..
Zfish   716 LLFIS---FLVHFQGWRIQFYWNIMVNRMLGSLKDAKVTEGRFQFDAYIIHAGEDKSWVERSLLS 777

  Fly   996 LENGRHKFRLCFY-LRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRL--ALHAT 1057
            ||:....|   || .||...|.|..:.|..::..||:||.::|:..||..|.| :|:.  |||..
Zfish   778 LEDKDLNF---FYEQRDSTPGHSRLETIVDNMVYSRKIIFVITEMLLKDPWCR-QFKAHHALHHV 838

  Fly  1058 SRDRCKRLIVVLYPDVEHFD 1077
            ..|....||::...||..::
Zfish   839 MEDNRDSLILIFLEDVTDYN 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	7/33 (21%)
		leucine-rich repeat	388..408	CDD:275380	8/20 (40%)
		LRR_8	412..465	CDD:290566	20/55 (36%)
		leucine-rich repeat	412..432	CDD:275378	7/19 (37%)
		LRR_4	432..470	CDD:289563	13/40 (33%)
		leucine-rich repeat	433..454	CDD:275378	8/23 (35%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	9/24 (38%)
		leucine-rich repeat	658..679	CDD:275378	6/30 (20%)
		leucine-rich repeat	680..706	CDD:275378	5/25 (20%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	5/35 (14%)
		leucine-rich repeat	793..815	CDD:275378	6/21 (29%)
		leucine-rich repeat	816..835	CDD:275378	3/30 (10%)
		leucine-rich repeat	836..859	CDD:275378	8/54 (15%)
		TIR	974..1110	CDD:214587	32/107 (30%)
tlr3	NP_001013287.2	LRR_RI	<49..183	CDD:238064	30/139 (22%)
		leucine-rich repeat	57..77	CDD:275380	7/21 (33%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR_8	125..183	CDD:290566	6/57 (11%)
		leucine-rich repeat	126..148	CDD:275380	3/21 (14%)
		leucine-rich repeat	149..172	CDD:275380	3/22 (14%)
		leucine-rich repeat	173..276	CDD:275380	19/107 (18%)
		LRR_8	275..331	CDD:290566	17/84 (20%)
		leucine-rich repeat	278..300	CDD:275380	5/47 (11%)
		leucine-rich repeat	301..324	CDD:275380	9/25 (36%)
		leucine-rich repeat	325..354	CDD:275380	6/30 (20%)
		leucine-rich repeat	355..378	CDD:275380	5/25 (20%)
		leucine-rich repeat	379..404	CDD:275380	5/27 (19%)
		LRR_8	406..466	CDD:290566	7/60 (12%)
		leucine-rich repeat	408..431	CDD:275380	2/22 (9%)
		leucine-rich repeat	432..456	CDD:275380	2/23 (9%)
		leucine-rich repeat	457..507	CDD:275380	8/49 (16%)
		leucine-rich repeat	482..498	CDD:275380	1/15 (7%)
		leucine-rich repeat	508..531	CDD:275380	6/22 (27%)
		leucine-rich repeat	532..563	CDD:275380	3/30 (10%)
		LRR_8	562..622	CDD:290566	10/59 (17%)
		leucine-rich repeat	564..587	CDD:275380	7/22 (32%)
		leucine-rich repeat	588..611	CDD:275380	0/22 (0%)
		leucine-rich repeat	612..630	CDD:275380	5/18 (28%)
		LRRCT	645..>683	CDD:214507	6/40 (15%)
		TIR	756..898	CDD:214587	32/107 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920