DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_005170910.1	Gene:	tlr2 / 403125	ZFINID:	ZDB-GENE-040219-6	Length:	818	Species:	Danio rerio

Alignment Length:	888	Identity:	192/888 - (21%)
Similarity:	308/888 - (34%)	Gaps:	302/888 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 CNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKG----------------SS-----ALVFQSNLL 419
            ||||.|             ||..:|::|....|                ||     .|....|.|
Zfish    65 CNCSSN-------------NLHQVPTVPSDVLGLDLSFNQIESINMTDLSSYNELIILNLHKNKL 116

  Fly   420 AELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLP--ESLHYLDIRHNKITTLSPQVV--------- 473
            ..:..::.:..|||:.||:|.|.|.:||.|...  :||..|::..|..:|:.|..:
Zfish   117 RHIHRDAFKSQHNLEVLDLSLNNLNNLSPSWFHKLKSLQQLNLVGNPYSTVGPAPIFKSLVNLRT 181

  Fly   474 ----------------EYLYSVNVFNQYGNKWSIYCD------------EYHLQEFF-------- 502
                            :.|..::....:|:....|.:            ...||..|
Zfish   182 LHLGSPSLRELHKNGLDVLTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLSLQNLFESDPELVS 246

  Fly   503 ------WYKAKLLRIK--TSKFQTIMEYIELSSKGSFVENFFVQN---IDQL---YLEANEDEII 553
                  .:...||.||  |.|..|..|..::..:|. .::...||   .||.   :||..:...:
Zfish   247 KVLQDVSHPETLLIIKDVTMKTNTSTEPFKMVKEGG-TKSLTFQNSSTTDQALTSFLEFMDGSPL 310

  Fly   554 DAFGPSDKYF---------------NLKLMEALNHAIWLFSGEFDEII-----LHHLNSPCPYRC 598
            ...|..|..|               :|:.....|..|..|.| |..:|     |.|.::
Zfish   311 SFIGLEDIQFVGIGEWQKAKYTHHDSLRTAYLRNIEIEGFFG-FSSMIELGFLLKHFHN------ 368

  Fly   599 SCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHM 663
                        ::..|.::.:.|        |.|.:|.:|                  :..:.:
Zfish   369 ------------VSVINATVFVIP--------KETTFLLKN------------------LEYMDL 395

  Fly   664 SQNLLRELPLHLLP---------ENITYLDVRNNLLKYLDDGVIAFLEYRENITK---IELSGNP 716
            |||||.:|.:.  |         :|:..|:|..|:||.|  |:::.|.  .|:.|   ::||.|
Zfish   396 SQNLLTDLTIQ--PTLYTGSGAYQNLNMLNVSQNVLKSL--GLMSRLV--TNLKKLKYLDLSYN- 453

  Fly   717 WECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDK------CPEDCICCVDTSNSDSLAYVVDCS 775
                       ||:...|...:...||.:.::..|      |....:..:|.|.:|..|:
Zfish   454 -----------SFVSMPEKCSWPVTLRFLNLSSTKLSTLTPCLPSSLTVLDLSENDLKAF----- 502

  Fly   776 GKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLP----DKL 836
               ....|.|       |||:...|.|.|.|...|  :.|:....:..|.|...:|..    ..|
Zfish   503 ---KQRFPHL-------TTLILTGNRLMKLPDGKL--FPSLNTLLIQRNALRMFNQSSLRSFKTL 555

  Fly   837 EYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAI 901
            .||:...|||                             .|.|:   |:.|.|:..:::..
Zfish   556 LYLEAGANNF-----------------------------VCSCK---FVSFFKKDVEDLIT---- 584

  Fly   902 QCIDTGRSLIEVEETDICP---------------SVLIYYTSLAVSLL----IIALSINVFICFR 947
              :..||      :..:|.               ||...|...|||:|    |.||.:.|..|.:
Zfish   585 --LQDGR------QNYVCNTPFTLRGNAIDSVRLSVFECYMIPAVSVLCFGIITALGLVVLTCHK 641

  Fly   948 QPIMIWFYEHEICLSLAARR----ELDEDKKYDAFLSFTHKDEDLIEE-FVDRLENGRHKFRLCF 1007
            ..: ||:.:.......|.|:    .|.|:.:||||:|::..|.:.:|| .|..||:.:..|.||.
Zfish   642 LHV-IWYLQMTKAWIQAKRKPAVGRLPEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCL 705

  Fly  1008 YLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLE-----FRLALHATSRDRCKRLIV 1067
            :.||:..|..|.|.|..|::.|.|.:.:::::|:.|.|.|.|     ||:    ........::|
Zfish   706 HKRDFRPGRWIVDNIIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFRI----MDEHNDSAVLV 766

  Fly  1068 VLYP-DVEHFDDLDSELRAYMVLNTYL-----DRNNPNFWNKL 1104
            :|.| ..|.......:||..|...|||     :.....||:.|
Zfish   767 LLEPIKKETIPKRFCKLRKIMNSRTYLEWPEDEDKRDEFWSNL 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	5/9 (56%)
		leucine-rich repeat	388..408	CDD:275380	4/19 (21%)
		LRR_8	412..465	CDD:290566	18/54 (33%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	15/39 (38%)
		leucine-rich repeat	433..454	CDD:275378	9/22 (41%)
		leucine-rich repeat	455..478	CDD:275378	6/47 (13%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	3/24 (13%)
		leucine-rich repeat	658..679	CDD:275378	7/29 (24%)
		leucine-rich repeat	680..706	CDD:275378	8/25 (32%)
		leucine-rich repeat	707..719	CDD:275378	4/14 (29%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	8/21 (38%)
		leucine-rich repeat	816..835	CDD:275378	3/22 (14%)
		leucine-rich repeat	836..859	CDD:275378	6/22 (27%)
		TIR	974..1110	CDD:214587	43/143 (30%)
tlr2	XP_005170910.1	leucine-rich repeat	85..105	CDD:275378	2/19 (11%)
		leucine-rich repeat	106..129	CDD:275378	3/22 (14%)
		LRR_8	108..163	CDD:290566	17/54 (31%)
		leucine-rich repeat	130..153	CDD:275378	9/22 (41%)
		leucine-rich repeat	154..178	CDD:275378	5/23 (22%)
		leucine-rich repeat	179..192	CDD:275378	0/12 (0%)
		LRR_RI	<390..501	CDD:238064	31/128 (24%)
		leucine-rich repeat	390..418	CDD:275380	7/29 (24%)
		LRR_8	418..478	CDD:290566	19/75 (25%)
		leucine-rich repeat	419..444	CDD:275380	9/28 (32%)
		leucine-rich repeat	445..467	CDD:275380	6/33 (18%)
		leucine-rich repeat	468..488	CDD:275380	4/19 (21%)
		leucine-rich repeat	489..508	CDD:275380	4/26 (15%)
		leucine-rich repeat	509..530	CDD:275380	9/29 (31%)
		leucine-rich repeat	531..554	CDD:275380	3/22 (14%)
		TIR	671..814	CDD:214587	43/143 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920