DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tlr2

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_005170910.2 Gene:tlr2 / 403125 ZFINID:ZDB-GENE-040219-6 Length:818 Species:Danio rerio


Alignment Length:886 Identity:193/886 - (21%)
Similarity:312/886 - (35%) Gaps:298/886 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 CNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKG----------------SS-----ALVFQSNLL 419
            ||||.|             ||..:|::|....|                ||     .|....|.|
Zfish    65 CNCSSN-------------NLHQVPTVPSDVLGLDLSFNQIESINMTDLSSYNELIILNLHKNKL 116

  Fly   420 AELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLP--ESLHYLDIRHNKITTLSPQVV--------- 473
            ..:..::.:..|||:.||:|.|.|.:||.|...  :||..|::..|..:|:.|..:         
Zfish   117 RHIHRDAFKSQHNLEVLDLSLNNLNNLSPSWFHKLKSLQQLNLVGNPYSTVGPAPIFSSLVNLRT 181

  Fly   474 ----------------EYLYSVNVFNQYGNKWSIYCD------------EYHLQEFF-------- 502
                            :.|..::....:|:....|.:            ...||..|        
Zfish   182 LHLGSPSLRELHKNGLDVLTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLSLQNLFESDPELVS 246

  Fly   503 ------WYKAKLLRIK--TSKFQTIMEYIELSSKGSFVENFFVQN---IDQL---YLEANEDEII 553
                  .:...||.||  |.|..|..|..::..:|. .::...||   .||.   :||..:...:
Zfish   247 KVLQDVSHPETLLIIKDVTMKTNTSTEPFKVVKEGG-TKSLTFQNSSTTDQALTSFLEFMDGSPL 310

  Fly   554 DAFGPSDKYF---------------NLKLMEALNHAIWLFSGEFDEII-----LHHLNSPCPYRC 598
            ...|..|..|               :|:.....|..|..|.| |..:|     |.|.::      
Zfish   311 SFIGLEDIQFVGIGEWQKAKYTHHDSLRTAYLRNIEIEGFFG-FSSMIELGFLLKHFHN------ 368

  Fly   599 SCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHM 663
                        ::..|.::.:.|        |.|.:|.:|                  :..:.:
Zfish   369 ------------VSVINATVFVIP--------KETTFLLKN------------------LEYMDL 395

  Fly   664 SQNLLRELPLHLLP---------ENITYLDVRNNLLKYLDDGVIAFLEYRENITK---IELSGNP 716
            |||||.:|.:.  |         :|:..|:|..|:||.|  |:::.|.  .|:.|   ::||.| 
Zfish   396 SQNLLTDLTIQ--PTLYTGSGAYQNLNMLNVSQNVLKSL--GLMSRLV--TNLKKLKYLDLSHN- 453

  Fly   717 WECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDK------CPEDCICCVDTSNSDSLAYVVDCS 775
                       ||:...|...:...||.:.::..|      |....:..:|.|.:|..|:     
Zfish   454 -----------SFVSMPEKCSWPVTLRFLNLSSTKLSTLTPCLPSSLTVLDLSENDLKAF----- 502

  Fly   776 GKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLP----DKL 836
               ....|.|       |||:...|.|.|.|...|  :.|::...:..|.|...:|..    ..|
Zfish   503 ---KQRFPHL-------TTLILTGNRLMKLPDGKL--FPSLSTLLIQRNALRMFNQSSLRSFKTL 555

  Fly   837 EYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAI 901
            .||:...|||                             .|.|:   |:.|.|   |::.:...:
Zfish   556 LYLEAGANNF-----------------------------VCSCK---FVSFFK---KDVEDLITL 585

  Fly   902 Q-----------------CIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQP 949
            |                 .||:.|  :.|.|..:.|:|     |:..|.:|.||.:.|..|.:..
Zfish   586 QDGRQNYVCNTPFTLRGNAIDSVR--LSVFECYMIPAV-----SVLCSGIITALGLVVLTCHKLH 643

  Fly   950 IMIWFYEHEICLSLAARR----ELDEDKKYDAFLSFTHKDEDLIEE-FVDRLENGRHKFRLCFYL 1009
            : ||:.:.......|.|:    .|.|:.:||||:|::..|.:.:|| .|..||:.:..|.||.:.
Zfish   644 V-IWYLQMTKAWIQAKRKPAVGRLPEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHK 707

  Fly  1010 RDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLE-----FRLALHATSRDRCKRLIVVL 1069
            ||:..|..|.|.|..|::.|.|.:.:::::|:.|.|.|.|     ||:    ........::|:|
Zfish   708 RDFRPGRWIVDNIIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFRI----MDEHNDSAVLVLL 768

  Fly  1070 YP-DVEHFDDLDSELRAYMVLNTYL-----DRNNPNFWNKL 1104
            .| ..|.......:||..|...|||     :.....||:.|
Zfish   769 EPIKKETIPKRFCKLRKIMNSRTYLEWPEDEDKRDEFWSNL 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 31/116 (27%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 5/9 (56%)
PRK15370 <381..>482 CDD:185268 29/148 (20%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR <416..591 CDD:443914 52/255 (20%)
leucine-rich repeat 433..454 CDD:275378 9/22 (41%)
leucine-rich repeat 455..478 CDD:275378 6/47 (13%)
leucine-rich repeat 479..490 CDD:275378 1/10 (10%)
leucine-rich repeat 632..657 CDD:275378 3/24 (13%)
leucine-rich repeat 658..679 CDD:275378 7/29 (24%)
leucine-rich repeat 680..706 CDD:275378 8/25 (32%)
PCC 684..>771 CDD:188093 23/95 (24%)
leucine-rich repeat 707..719 CDD:275378 4/14 (29%)
leucine-rich repeat 771..791 CDD:275380 2/19 (11%)
PRK15370 <793..>877 CDD:185268 18/87 (21%)
leucine-rich repeat 793..815 CDD:275378 8/21 (38%)
leucine-rich repeat 816..835 CDD:275378 3/22 (14%)
leucine-rich repeat 836..859 CDD:275378 6/22 (27%)
TIR 974..1110 CDD:214587 43/143 (30%)
tlr2XP_005170910.2 None
Blue background indicates that the domain is not in the aligned region.

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