Protein Alignment Toll-4 and CG4950

DIOPT Version :10

• Sequence 1: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 115/549 - (20%)
• Similarity: 197/549 - (35%)
• Gaps: 179/549 - (32%)

  Fly   151 ELVIISVLGIRS------EVDMRISPAVQYLSLLGIREISGY-DIYLPSVLITEMDVHHA----- 203
            |:::|.:|.|.|      ::.:|..   :|.|:       || |:......:|...|.|:
  Fly     9 EVIVILILAISSCDGSGGDIPLRCD---EYDSM-------GYMDVNEAFCTVTGFTVTHSQNVVI 63

  Fly   204 -NGP--KMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMS 265
             |.|  .||.|...|:||:  :....::.:|....:.:.:...|..|.|     :|.|...:.::
  Fly    64 KNIPPGNMVKFMKFYESTL--LYMPFHLFETFPYLKTLDVSNTNILELT-----RNAFSAASNLT 121

  Fly   266 ALIFNGLKIKGLTNNTFENLTSLNTLIF--DNVFLK-DLSFLRSSTLQSSLTYC-------IMKV 320
            .|           |..:.||||:.|.:|  .||.:: |||:...|:| |...:|       |...
  Fly   122 YL-----------NLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSL-SVNAFCGLHTISQIYLT 174

  Fly   321 DNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNR--- 382
            .|::.....:.|.:.|.:|...::| ...|:...|.:::..:    |.||      |.|.||
  Fly   175 GNLLKELHNDIFKDNEYLEKVSFEG-NLLTSIQPEVFRNMRR----IKEV------NLSNNRLIF 228

  Fly   383 -------DKSQLE-----------IDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNS--- 426
                   |.:.||           ....:||:.            ..|...:|.|..|..|:
  Fly   229 IHPDTFADAASLENLVLSYNELKNFQLTEKNIV------------HQLHLDNNYLTNLTINATRF 281

  Fly   427 LEGYHN------------LKSLDVSYNQLTSLS-VSQLPESLHYLDIRHNKITTLSPQVVEYLYS 478
            :...||            :::||:|.|:|:|:| ::.:...| |||:..|.|..|:......|..
  Fly   282 VRASHNQISELFLHQSLHIETLDLSANKLSSISNITNITHML-YLDVSDNPIGPLNISTFSQLKR 345

  Fly   479 VNVFNQYGN-----KWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQ 538
            :...|..|.     |:.::..:.:|:|                      ::||     ..|..:.
  Fly   346 LRGLNLRGTGIRELKFGMFSKQKYLEE----------------------LDLS-----FNNLTIL 383

  Fly   539 NIDQL--YLEANEDEIIDAFGPSDKYFNLKLMEALN--HAIWLFSGEFDEIILHHLNSPCPYRCS 599
            |:|..  ||...:..:||..|.::...|....||..  ..:.:....|:...||||..|
  Fly   384 NLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHLLIP------ 442

  Fly   600 CCFEWHTGEFLINCRNLSLDIYPRLPNSI 628
                                  |.||.|:
  Fly   443 ----------------------PSLPESV 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	LRR	210..>470	CDD:443914	68/306 (22%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..308	CDD:275380	7/22 (32%)
		leucine-rich repeat	309..334	CDD:275380	6/31 (19%)
		leucine-rich repeat	335..386	CDD:275380	13/60 (22%)
		PRK15370	<381..>482	CDD:185268	29/137 (21%)
		leucine-rich repeat	388..408	CDD:275380	3/30 (10%)
		leucine-rich repeat	412..432	CDD:275378	5/22 (23%)
		LRR	<416..591	CDD:443914	43/199 (22%)
		leucine-rich repeat	433..454	CDD:275378	7/21 (33%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	3/15 (20%)
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		PCC	684..>771	CDD:188093
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		PRK15370	<793..>877	CDD:185268
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
CG4950	NP_648855.2	LRR	96..411	CDD:443914	79/382 (21%)
		leucine-rich repeat	96..119	CDD:275380	5/27 (19%)
		leucine-rich repeat	120..143	CDD:275380	8/33 (24%)
		leucine-rich repeat	144..167	CDD:275380	7/23 (30%)
		leucine-rich repeat	168..191	CDD:275380	3/22 (14%)
		leucine-rich repeat	192..215	CDD:275380	4/23 (17%)
		leucine-rich repeat	216..239	CDD:275380	8/28 (29%)
		leucine-rich repeat	240..299	CDD:275380	11/70 (16%)
		leucine-rich repeat	300..321	CDD:275380	7/20 (35%)
		leucine-rich repeat	322..345	CDD:275380	8/23 (35%)
		leucine-rich repeat	346..365	CDD:275380	3/18 (17%)
		leucine-rich repeat	370..394	CDD:275380	9/50 (18%)
		leucine-rich repeat	395..420	CDD:275380	6/24 (25%)